利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.038 秒)

    IDENTIFICATION OF CELLULAR POLYPEPTIDES DIFFERENTIALLY EXPRESSED BY TUMOR CELLS
    2.
    发明公开
    IDENTIFICATION OF CELLULAR POLYPEPTIDES DIFFERENTIALLY EXPRESSED BY TUMOR CELLS 审中-公开
    识别细胞多肽具有肿瘤细胞中差异表达HAVE

    公开(公告)号：EP1589997A2

    公开(公告)日：2005-11-02

    申请号：EP04708670.7

    申请日：2004-02-05

    申请人： GENENTECH, INC.

    发明人： FRANTZ, Gretchen ,  HILLAN, Kenneth ,  POLAKIS, Paul ,  WOLF, Beni ,  WU, Thomas ,  ZHANG, Zemin

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K47/48

    CPC分类号： C07K16/30

    摘要： The present invention is directed to the identification of various cellular polypeptides (and their encoding nucleic acids or fragments thereof) which are expressed to a greater degree on the surface of or by one or more types of cancer cell(s) as compared to on the surface of or by one or more types of normal non-cancer cells. Alternatively, such polypeptides are expressed by cells which produce and/or secrete polypeptides having a potentiating or growth-enhancing effect on cancer cells. Again alternatively, such polypeptides may not be overexpressed by tumor cells as compared to normal celles of the same tissue type, but rather may be specifically expressed by both tumor cells and normal cells of only a single or very limited number of tissue types (preferably tissues which are not essential for life, e.g. prostate, etc.).

    COMPOSITIONS AND METHOD FOR THE TREATEMENT OF TUMORS
    8.
    发明公开
    COMPOSITIONS AND METHOD FOR THE TREATEMENT OF TUMORS 审中-公开
    组合物和治疗肿瘤的方法

    公开(公告)号：EP1141289A2

    公开(公告)日：2001-10-10

    申请号：EP99966374.3

    申请日：1999-12-16

    申请人： Genentech, Inc.

    发明人： BOTSTEIN, David ,  GODDARD, Audrey ,  GURNEY, Austin, L. ,  HILLAN, Kenneth ,  LAWRENCE, David, A. ,  ROY, Margaret, Ann ,  WOOD, William, I.

    IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/62 ,  C12N15/11 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K2317/24 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/472

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。 本发明基于鉴定在肿瘤细胞基因组中扩增的基因。 与相同组织类型的正常细胞相比，预计这种基因扩增与基因产物的过度表达相关并且有助于肿瘤发生。 因此，由扩增基因编码的蛋白质被认为是用于某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以充当肿瘤治疗预后的预测因子。 本发明涉及新的多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。