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公开(公告)号：EP0888385A2
公开(公告)日：1999-01-07
申请号：EP97915160.0
申请日：1997-03-13
申请人： Genentech, Inc.
IPC分类号： C12N15 , A01K67 , A61K31 , A61K38 , A61K39 , A61P13 , C07K14 , C07K16 , C07K19 , C12N5 , C12P21 , G01N33
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
摘要： GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRæ (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.
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公开(公告)号：EP1064376B1
公开(公告)日：2006-03-15
申请号：EP99913993.4
申请日：1999-03-19
申请人： GENENTECH, INC.
IPC分类号： C12N15/12 , C07K14/71 , C12N15/85 , C12N15/70 , C12N15/81 , C12N1/19 , C12N5/10 , C12N1/21 , C07K19/00 , C07K16/28 , G01N33/68 , C12Q1/42 , A61K39/395
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
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公开(公告)号：EP1007666B1
公开(公告)日：2005-12-14
申请号：EP98906558.6
申请日：1998-02-17
申请人： GENENTECH, INC.
IPC分类号： C12N15/12 , C07K14/71 , C07K19/00 , C07K16/46 , G01N33/68 , C07K1/22 , C07K16/28 , A61K38/17 , A61K39/395 , C12N15/85 , C12N5/10 , A01K67/027
CPC分类号： C07K14/71 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00
摘要： NTNR alpha , NTNR alpha extracellular domain (ECD), NTNR alpha variants, chimeric NTNR alpha (e.g., NTNR alpha immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR alpha -ligands, for example NTN, by providing NTNR alpha to the cell.
摘要翻译： NTNRα，NTNRα胞外结构域（ECD），NTNRα变体，嵌合NTNRα（例如NTNRα免疫粘附）和与其结合的抗体（包括激动剂和中和抗体）。 描述了这些分子的各种用途，包括通过向细胞提供NTNRα而响应于NTNRα-配体，例如NTN，调节细胞活性和存活的方法。
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公开(公告)号：EP0888385B1
公开(公告)日：2003-08-20
申请号：EP97915160.2
申请日：1997-03-13
申请人： Genentech, Inc.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
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公开(公告)号：EP1121439A2
公开(公告)日：2001-08-08
申请号：EP99970398.6
申请日：1999-10-05
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi , GODDARD, Audrey , GURNEY, Austin, L. , KLEIN, Robert, D. , NAPIER, Mary , WOOD, William, I. , YUAN, Jean
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds.
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公开(公告)号：EP1007666A1
公开(公告)日：2000-06-14
申请号：EP98906558.6
申请日：1998-02-17
申请人： Genentech, Inc.
IPC分类号： C12N15/12 , C07K14/71 , C07K19/00 , C07K16/46 , G01N33/68 , C07K1/22 , C07K16/28 , A61K38/17 , A61K39/395 , C12N15/85 , C12N5/10 , A01K67/027
CPC分类号： C07K14/71 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00
摘要： NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNRα-ligands, for example NTN, by providing NTNRα to the cell.
摘要翻译： NTNRα，NTNRα细胞外结构域（ECD），NTNRα变体，嵌合NTNRα（例如NTNRα免疫粘附）和与其结合的抗体（包括激动剂和中和抗体）。 描述了这些分子的各种用途，包括通过向细胞提供NTNRα而响应于NTNRα-配体（例如NTN）来调节细胞活性和存活的方法。
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7.发明授权PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 有权促销或血管生成与KARDIOVASKULARISATION的抑制作用
公开(公告)号：EP1135485B1
公开(公告)日：2010-02-17
申请号：EP99960624.7
申请日：1999-11-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , HILLAN, Kenneth, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KLEIN, Robert, D. , KUO, Sophia, S. , PAONI, Nicholas, F. , SMITH, Victoria , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
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公开(公告)号：EP1121439B1
公开(公告)日：2006-07-12
申请号：EP99970398.6
申请日：1999-10-05
申请人： GENENTECH, INC.
发明人： ASHKENAZI, Avi , GODDARD, Audrey , GURNEY, Austin, L. , KLEIN, Robert, D. , NAPIER, Mary , WOOD, William, I. , YUAN, Jean
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds.
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9.发明公开PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 有权促销或血管生成与KARDIOVASKULARISATION的抑制作用
公开(公告)号：EP1135485A2
公开(公告)日：2001-09-26
申请号：EP99960624.7
申请日：1999-11-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , HILLAN, Kenneth, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KLEIN, Robert, D. , KUO, Sophia, S. , PAONI, Nicholas, F. , SMITH, Victoria , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1064376A2
公开(公告)日：2001-01-03
申请号：EP99913993.4
申请日：1999-03-19
申请人： Genentech, Inc.
IPC分类号： C12N15/12 , C07K14/71 , C12N15/85 , C12N15/70 , C12N15/81 , C12N1/19 , C12N5/10 , C12N1/21 , C07K19/00 , C07K16/28 , G01N33/68 , C12Q1/42 , A61K39/395
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTS'S), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRx3, a x-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an x-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced x-subunit receptor homo-dimerization or homo-oligomerization.
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