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公开(公告)号：EP2411414A1
公开(公告)日：2012-02-01
申请号：EP10722819.9
申请日：2010-03-24
发明人： ASHKENAZI, Avi , QING, Jing , WIESMANN, Christian , WU, Yan
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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公开(公告)号：EP2496695A1
公开(公告)日：2012-09-12
申请号：EP10774413.8
申请日：2010-11-04
CPC分类号： C12N9/6424 , C07K16/18 , C07K2299/00 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： The present invention is directed towards the co-crystal structure of Factor D and an anti-Factor D antibody or an antigen binding fragment thereof.
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公开(公告)号：EP3141560A3
公开(公告)日：2017-05-24
申请号：EP16173577.4
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61P37/00 , A61K38/17
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
摘要翻译： 本发明涉及亲和力成熟的CRIg变体。 具体而言，本发明涉及对C3b具有增加的结合亲和力并保持与C3b对C3b的选择性结合的CRIg变体。
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公开(公告)号：EP3141560A2
公开(公告)日：2017-03-15
申请号：EP16173577.4
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61P37/00 , A61K38/17
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
摘要翻译： 本发明涉及亲和力成熟的CRIg变体。 特别地，本发明涉及具有增加的对C3b的结合亲和力并保留在C3上选择性结合C3b的CRIg变体。
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公开(公告)号：EP2111413A2
公开(公告)日：2009-10-28
申请号：EP08729968.1
申请日：2008-02-15
申请人： Genentech, Inc.
发明人： APPLETON, Brent, A. , RUNYON, Steven, T. , SIDHU, Sachdev, S. , SKELTON, Nicholas, J. , WIESMANN, Christian , ZHANG, Yingnan
IPC分类号： C07K14/435
CPC分类号： C07K7/08 , C07K5/1008 , C07K7/06 , C12N9/6424
摘要： The invention provides optimized HtrA1 PDZ domain and HtrA3 PDZ domain ligands. The invention further provides modulators of HtrA1 PDZ domain-ligand interaction and HtrA3 PDZ domain-ligand interaction, and methods of identifying and using these modulators.
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6.发明授权CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES 有权NEUROPILINFRAGMENTEN的晶体结构和神经毡抗体复合物
公开(公告)号：EP2158215B1
公开(公告)日：2015-04-22
申请号：EP07762242.1
申请日：2007-05-17
申请人： Genentech, Inc.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , C07K16/2863 , C07K2299/00 , C07K2317/55 , C07K2317/76
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7.发明公开CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES 有权NEUROPILINFRAGMENTEN的晶体结构和神经毡抗体复合物
公开(公告)号：EP2158215A2
公开(公告)日：2010-03-03
申请号：EP07762242.1
申请日：2007-05-17
申请人： Genentech, Inc.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , C07K16/2863 , C07K2299/00 , C07K2317/55 , C07K2317/76
摘要： The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.
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8.发明公开
公开(公告)号：EP2152755A1
公开(公告)日：2010-02-17
申请号：EP08756130.4
申请日：2008-05-22
申请人： Genentech, Inc.
发明人： HASS, Philip , JIANPING, Yin , KATSCHKE, Kenneth, Jr. , STEFFEK, Micah , WIESMANN, Christian , VAN LOOKEREN CAMPAGNE, Menno
IPC分类号： C07K16/40 , C12N9/64 , A61P27/02 , A61P37/00 , A61K39/395
CPC分类号： C07K16/40 , A61K9/0048 , A61K39/3955 , A61K2039/505 , C07K2317/20 , C07K2317/24 , C07K2317/56 , C07K2317/565 , Y10S435/975
摘要： The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration of Factor D antagonists.
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公开(公告)号：EP3702371A1
公开(公告)日：2020-09-02
申请号：EP19175988.5
申请日：2010-03-24
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi , QING, Jing , WIESMANN, Christian , WU, Yin
IPC分类号： C07K16/28 , A61K39/395
摘要： The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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公开(公告)号：EP2280996B1
公开(公告)日：2016-09-07
申请号：EP09743591.1
申请日：2009-05-06
申请人： Genentech, Inc.
IPC分类号： C07K14/705 , G01N33/68 , A61K38/17 , A61P37/00
CPC分类号： A61K38/1774 , A61K38/00 , C07K14/70503 , Y02A50/463
摘要： The present invention concerns affinity matured CRIg variants. In particular, the invention concerns CRIg variants having increased binding affinity to C3b and retaining selective binding to C3b over C3.
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