公开(公告)号：EP1784426B1

公开(公告)日：2011-11-23

申请号：EP05810856.4

申请日：2005-09-02

申请人： Genentech, Inc.

发明人： DENNIS, Mark, S. ,  FONG, Sherman

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2839 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies

公开(公告)号：EP1240325B1

公开(公告)日：2009-09-30

申请号：EP00989401.5

申请日：2000-12-20

申请人： Genentech, Inc.

发明人： CHEN, Jian ,  FILVAROFF, Ellen ,  FONG, Sherman ,  GODDARD, Audrey ,  GODOWSKI, Paul, J. ,  GRIMALDI, Christopher, J. ,  GURNEY, Austin, L. ,  LI, Hanzhong ,  HILLAN, Kenneth, J. ,  TUMAS, Daniel ,  VAN LOOKEREN, Menno ,  VANDLEN, Richard, L. ,  WATANABE, Colin, K. ,  WILLIAMS, P., Mickey ,  WOOD, William, I. ,  YANSURA, Daniel, G.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C07K14/54 ,  C12N15/62 ,  C07K16/24 ,  C07K16/28 ,  A61K31/70 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  G01N33/566 ,  G01N33/53

CPC分类号： C07K14/54 ,  C07K14/7155

公开(公告)号：EP1601693A2

公开(公告)日：2005-12-07

申请号：EP04719326.3

申请日：2004-03-10

申请人： GENENTECH, INC.

发明人： BALDWIN, Daryl ,  BODARY, Sarah ,  CLARK, Hilary ,  FONG, Sherman ,  GURNEY, Austin, L. ,  WILLIAMS, P., Mickey

IPC分类号： C07K14/47

CPC分类号： C07K14/4713 ,  A61K38/00 ,  C07K14/47

摘要： The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.

公开(公告)号：EP1141285A2

公开(公告)日：2001-10-10

申请号：EP99962992.6

申请日：1999-12-01

申请人： Genentech, Inc.

发明人： BOTSTEIN, David ,  DESNOYERS, Luc ,  FERRARA, Napoleone ,  FONG, Sherman ,  GAO, Wei-Qiang ,  GODDARD, Audrey ,  GURNEY, Austin, L. ,  PAN, James ,  ROY, Margaret, Ann ,  STEWART, Timothy, A. ,  TUMAS, Daniel ,  WATANABE, Colin, K. ,  WOOD, William, I.

IPC分类号： C12N15/12 ,  C12N9/02 ,  C07K14/47 ,  C07K14/705 ,  C12N15/62 ,  C07K16/18

CPC分类号： C12N9/001 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1114154A2

公开(公告)日：2001-07-11

申请号：EP99952930.8

申请日：1999-09-15

申请人： Genentech, Inc.

发明人： FONG, Sherman ,  GODDARD, Audrey ,  GURNEY, Austin, L. ,  TUMAS, Daniel ,  WOOD, William, I.

IPC分类号： C12N15/12 ,  C07K14/47 ,  A61K38/17 ,  C07K16/18 ,  G01N33/50

摘要： The present invention relates to a composition containing novel proteins and methods for the diagnosis and treatment of immune related diseases.

公开(公告)号：EP3530673A1

公开(公告)日：2019-08-28

申请号：EP18181899.8

申请日：2005-09-02

申请人： Genentech, Inc.

发明人： DENNIS, Mark, S. ,  FONG, Sherman

IPC分类号： C07K16/28 ,  A61K39/395 ,  C07K16/18

摘要： The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies

公开(公告)号：EP1945674A2

公开(公告)日：2008-07-23

申请号：EP06850090.9

申请日：2006-11-01

申请人： Genentech, Inc.

发明人： FONG, Sherman ,  HU, Zhilan

IPC分类号： C07K19/00 ,  C07K16/30 ,  C07K14/705 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/32 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00

摘要： Therapeutic protein fusions comprising anti-HER2 antibody and MicB sequences are described along with methods for their production and use

公开(公告)号：EP1341814A2

公开(公告)日：2003-09-10

申请号：EP01985272.2

申请日：2001-08-29

申请人： GENENTECH, INC.

发明人： BAKER, Kevin P. ,  EATON, Dan L. ,  FILVAROFF, Ellen ,  GODDARD, Audrey ,  GRIMALDI, J. Christopher ,  GURNEY, Austin L. ,  SMITH, Victoria ,  STEPHAN, Jean-Philippe ,  WATANABE, Colin K. ,  WOOD, William I. ,  ZHANG, Zemin ,  FONG, Sherman

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  C12N15/62 ,  A61K38/17

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：EP1263948A2

公开(公告)日：2002-12-11

申请号：EP00907314.9

申请日：2000-02-18

申请人： Genentech, Inc.

发明人： ASZKENAZI, Avi J. ,  BAKER, Kevin P. ,  BOTSTEIN, David ,  DESNOYERS, Luc ,  EATON, Dan L. ,  FERRARA, Napoleone ,  FILVAROFF, Ellen ,  FONG, Sherman ,  GAO, Wei-Qiang ,  GERBER, Hanspeter ,  GERRITSEN, Mary E. ,  GODDARD, Audrey ,  GODOWSKI, Paul J. ,  GRIMALDI, Christopher G. ,  GURNEY, Austin L. ,  HILLAN, Kenneth J. ,  KLJAVIN, Ivar J. ,  KUO, Sophia S. ,  NAPIER, Mary A. ,  PAN, James ,  PAONI, Nicholas F. ,  ROY, Margaret Ann ,  SHELTON, David L. ,  STEWART, Timothy A. ,  TUMAS, Daniel ,  WILLIAMS, P. Mickey ,  WOOD, William I.

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C07K14/47 ,  C07K14/705 ,  C07K19/00 ,  C07K16/18 ,  C07K16/28 ,  G01N33/68 ,  G01N33/543 ,  A61K47/48 ,  A61K51/08 ,  A61K38/17

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C12N2799/026 ,  C12N2799/027

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：EP1078006A1

公开(公告)日：2001-02-28

申请号：EP99922996.6

申请日：1999-05-12

申请人： Genentech, Inc.

发明人： FONG, Sherman ,  HILLAN, Kenneth, J.

IPC分类号： C07K16/28 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  G01N33/576 ,  G01N33/577 ,  C12N5/20

CPC分类号： C07K16/2803 ,  A61K38/00 ,  C07K14/70503 ,  C07K14/70546 ,  C07K16/2839 ,  C07K2319/00

摘要： The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM binding partner or ligand. These compositions are useful in treating diseases or disorders involving α4β7/MAdCAM blockade, as well as inhibiting a primary event in the inflammatory response such as blocking interactions between intercellular adhesion molecules and their ligands. Disorders treatable using the methods disclosed herein include infections, especially viral infections, iatrogenic disorders, cholestatic disorders, hereditary disorders, sarcoidosis, organ transplant, and the like. The diagnostic methods of the invention can be employed to detect the presence of a disorder or to monitor the course of therapy used to treat the disorder.