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公开(公告)号：EP3695844A1
公开(公告)日：2020-08-19
申请号：EP20152978.1
申请日：2015-10-29
发明人： CHUN, Byoung, Kwon , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER, Edward , HUI, Hon, Chung , JORDAN, Robert , MACKMAN, Richard, L. , PARRISH, Jay, P. , RAY, Adrian, S. , SIEGEL, Dustin
IPC分类号： A61K31/706 , A61K31/675 , A61K31/685 , C07D487/04 , C07D519/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/683 , A61P31/14 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61P31/00 , A61P31/12 , A61P43/00 , A61K31/7056
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV:
The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.-
公开(公告)号：EP3212174B1
公开(公告)日：2018-05-16
申请号：EP15797205.0
申请日：2015-10-29
发明人： CHUN, Byoung, Kwon , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER,Edward , HUI, Hon, Chung , JORDAN, Robert , MACKMAN, Richard, L. , PARRISH, Jay, P. , RAY, Adrian, S. , SIEGEL, Dustin
IPC分类号： A61K31/00 , A61K31/53 , A61K31/675 , A61K31/685 , C07H1/00 , C07H11/00 , C07H15/18 , C07D487/04 , C07D519/00 , C07H1/02 , A61P31/14
CPC分类号： A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K31/7056 , A61K31/706 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：EP2523950B1
公开(公告)日：2017-03-15
申请号：EP11700988.6
申请日：2011-01-14
发明人： CANALES, Eda , CLARKE, Michael, O'Neil Hanrahan , LAZERWITH, Scott, E. , LEW, Willard , MORGANELLI, Philip, Anthony , WATKINS, William, J.
IPC分类号： C07D409/12 , A61K31/381 , A61K31/4436 , A61P31/00
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436 , A61K45/06
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公开(公告)号：EP3366295B1
公开(公告)日：2020-01-22
申请号：EP18167340.1
申请日：2015-10-29
发明人： CHUN, Byoung, Kwon , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER, Edward , HUI, Hon, Chung , JORDAN, Robert , MACKMAN, Richard, L. , PARRISH, Jay, P. , RAY, Adrian, S. , SIEGEL, Dustin
IPC分类号： A61K31/675 , A61K31/685 , C07D487/04 , C07D519/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/683 , A61P31/14
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公开(公告)号：EP3212174A1
公开(公告)日：2017-09-06
申请号：EP15797205.0
申请日：2015-10-29
发明人： CHUN, Byoung, Kwon , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER,Edward , HUI, Hon, Chung , JORDAN, Robert , MACKMAN, Richard, L. , PARRISH, Jay, P. , RAY, Adrian, S. , SIEGEL, Dustin
IPC分类号： A61K31/00 , A61K31/53 , A61K31/675 , A61K31/685 , C07H1/00 , C07H11/00 , C07H15/18 , C07D487/04 , C07D519/00 , C07H1/02 , A61P31/14
CPC分类号： A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
摘要翻译： 本发明提供了用于治疗丝状病毒科病毒感染的化合物，方法和药物组合物，其通过施用式IV的核糖苷，核苷磷酸酯及其前药：所提供的化合物，组合物和方法对于治疗马尔堡病毒，埃博拉病毒和库埃瓦 病毒感染。
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6.发明授权METHODS FOR THE PREPARATION OF DIASTEROMERICALLY PURE PHOSPHORAMIDATE PRODRUGS 有权程序对DIASTEROMERENREINEN磷酸酯前药的制备
公开(公告)号：EP2596004B1
公开(公告)日：2014-09-10
申请号：EP11743400.1
申请日：2011-07-19
CPC分类号： C07H1/00 , A61K31/7042 , A61K31/7052 , C07F9/2458 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/02 , C07H19/10 , C07H19/20
摘要： Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs ofnucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
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公开(公告)号：EP3366295A1
公开(公告)日：2018-08-29
申请号：EP18167340.1
申请日：2015-10-29
发明人： CHUN, Byoung, Kwon , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER, Edward , HUI, Hon, Chung , JORDAN, Robert , MACKMAN, Richard, L. , PARRISH, Jay, P. , RAY, Adrian, S. , SIEGEL, Dustin
IPC分类号： A61K31/675 , A61K31/685 , C07D487/04 , C07D519/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/683 , A61P31/14
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV:
The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.-
公开(公告)号：EP2523951B1
公开(公告)日：2015-04-22
申请号：EP11701588.3
申请日：2011-01-14
发明人： CANALES, Eda , CHONG, Lee, S. , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER, Edward , LAZERWITH, Scott, E. , LEW, Willard , MERTZMAN, Michael , MORGANELLI, Philip, Anthony , WATKINS, William, J.
IPC分类号： C07D409/12 , C07D409/14 , C07D493/04 , A61K31/381 , A61K31/4436 , A61P31/00
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
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9.发明公开METHODS FOR THE PREPARATION OF DIASTEROMERICALLY PURE PHOSPHORAMIDATE PRODRUGS 有权程序对DIASTEROMERENREINEN磷酸酯前药的制备
公开(公告)号：EP2596004A1
公开(公告)日：2013-05-29
申请号：EP11743400.1
申请日：2011-07-19
CPC分类号： C07H1/00 , A61K31/7042 , A61K31/7052 , C07F9/2458 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07H19/02 , C07H19/10 , C07H19/20
摘要： Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs ofnucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.
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公开(公告)号：EP2523951A1
公开(公告)日：2012-11-21
申请号：EP11701588.3
申请日：2011-01-14
发明人： CANALES, Eda , CHONG, Lee, S. , CLARKE, Michael, O'Neil Hanrahan , DOERFFLER, Edward , LAZERWITH, Scott, E. , LEW, Willard , MERTZMAN, Michael , MORGANELLI, Philip, Anthony , WATKINS, William, J.
IPC分类号： C07D409/12 , C07D409/14 , C07D493/04 , A61K31/381 , A61K31/4436 , A61P31/00
CPC分类号： C07D333/38 , A61K31/381 , A61K31/4025 , A61K31/427 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/501 , A61K45/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04
摘要： Provided are compounds of Formula (I): and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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