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公开(公告)号：EP0804546A1
公开(公告)日：1997-11-05
申请号：EP95911712.0
申请日：1995-01-20
CPC分类号： C12N9/0004 , A61K38/00 , A61K39/00
摘要： A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also dislcosed.
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公开(公告)号：EP0826041A1
公开(公告)日：1998-03-04
申请号：EP95921317.0
申请日：1995-05-19
发明人： WEI, Ying-Fei , MEISSNER, Paul, S. , NI, Jian
IPC分类号： G01N33 , A61K31 , A61K38 , A61K39 , A61K45 , A61K48 , A61P17 , A61P25 , A61P35 , A61P37 , A61P43 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12Q1 , C12R1
CPC分类号： C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
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公开(公告)号：EP0856050A1
公开(公告)日：1998-08-05
申请号：EP96921363.0
申请日：1996-06-06
IPC分类号： C12N15 , A61K31 , A61K38 , A61K39 , A61K45 , A61K48 , A61P1 , A61P9 , A61P13 , A61P15 , A61P17 , A61P25 , A61P27 , A61P35 , A61P43 , C07H21 , C07K14 , C07K16 , C12N1 , C12P21 , C12Q1 , G01N33 , C12R1
CPC分类号： C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
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公开(公告)号：EP0784672A1
公开(公告)日：1997-07-23
申请号：EP94930440.0
申请日：1994-09-16
IPC分类号： C12N15 , A61K38 , A61K39 , A61K45 , A61K48 , A61P13 , A61P15 , A61P25 , A61P43 , C07K16 , C12N5 , C12N9 , C12Q1 , C12R1
摘要： Human inositol monophosphatase H1 polynucleotide and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, screening and designing compounds capable of inhibiting hIMP-H1 and mapping genetic diseases are disclosed. Also disclosed are antagonists against such polypeptide along with procedures for using such antagonists for therapeutic purposes, for example, for treating psychotic and depressive disorders.
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公开(公告)号：EP0826041B1
公开(公告)日：2010-12-08
申请号：EP95921317.4
申请日：1995-05-19
发明人： WEI, Ying-Fei , MEISSNER, Paul, S. , NI, Jian
IPC分类号： C12N15/12 , C12N15/18 , C12N15/19 , C07K14/495
CPC分类号： C07K14/495 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
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公开(公告)号：EP0879240A1
公开(公告)日：1998-11-25
申请号：EP95922961.0
申请日：1995-06-05
IPC分类号： C12N15 , A61K39 , A61K45 , A61P35 , A61P43 , C07K14 , C07K16 , C12N5 , C12P21 , C12Q1 , G01N33
CPC分类号： C07K14/475 , C07K14/52 , C07K16/22
摘要： A human Criptin Growth Factor polypeptide (CGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonist against such polypeptides and their use as a therapeutic to treat and/or prevent neoplasia such as tumors is also disclosed. Diagnostic assays for identifying mutations in CGF nucleic acid sequences and altered levels of the CGF for the detection of cancer are also disclosed.
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