VERFAHREN ZUR HERSTELLUNG VON SCLAREOLID
    6.
    发明授权
    VERFAHREN ZUR HERSTELLUNG VON SCLAREOLID 失效
    用于生产sclareolid

    公开(公告)号:EP0636126B1

    公开(公告)日:1997-01-08

    申请号:EP93909365.4

    申请日:1993-04-08

    IPC分类号: C07D307/92

    CPC分类号: C07D307/92

    摘要: Sclareolide, an important preliminary product for the production of the perfume ambroxane, is accessible in large quantities with short reaction times by the reaction of sclareol and/or abienol in an aqueous medium and in the absence of an organic solvent with a 10.5 to 25-fold molar quantity of an oxidising agent in the presence of a ruthenium catalyst and an emulsifier to form a raw product and either (i) its conversion in the presence of a base into the salt of 8α-hydroxy-11-carboxy-12,13,14,15,16-pentanorlabdane and its further cycling in an acid medium, or (ii) is subsequent reaction at increased temperature and subsequent distillation, whereby the post-reaction may also, if desired, take place in situ during distillation.

    VERFAHREN ZUR HERSTELLUNG VON 8,12-OXIDO-13,14,15,16-TETRANORLABDAN

    公开(公告)号:EP0596923B1

    公开(公告)日:1996-12-27

    申请号:EP92915504.2

    申请日:1992-07-10

    发明人: GERKE, Thomas

    IPC分类号: C07D307/92

    CPC分类号: C07D307/92

    摘要: The invention concerns the cyclization, by the removal of water, of mixtures of stereoisomers of 8,12-dihydroxy-13,14,15,16-tetranorlabdane in the presence of acidified aluminium oxide. The cyclization reaction gives yields of at least 95 % of mixtures of stereoisomers of 8,12-oxido-13,14,15,16-tetranorlabdane.

    摘要翻译: 本发明涉及在酸化的氧化铝存在下,通过除去水,8,12-二羟基-13,14,15,16-四去甲二十烷的立体异构体的混合物的环化。 环化反应产生至少95%的8,12-氧代-13,14,15,16-四去甲戊二烷的立体异构体混合物。

    VERFAHREN ZUR HERSTELLUNG VON 8,12-OXIDO-13,14,15,16-TETRANORLABDAN

    公开(公告)号:EP0596923A1

    公开(公告)日:1994-05-18

    申请号:EP92915504.0

    申请日:1992-07-10

    发明人: GERKE, Thomas

    IPC分类号: C07D307

    CPC分类号: C07D307/92

    摘要: On obtient des mélanges de stéréoisomères de 8,12-oxido-13,14,15,16-tétranorlabdane, avec un rendement d'au moins 95 %, par cyclisation déshydratante de mélanges de stéréoisomères de 8,12-dihydroxy-13,14,15,16-tétranorlabdane en présence d'oxyde d'aluminium acidifié.

    摘要翻译: 获得-8,12-氧桥13,14,15,16-tetranorlabdane的立体异构体的混合物,其中至少95%的产率,由8,12二羟基-13,14-立体异构体混合物的环化脱水 ,15,16-四去烷,在酸化的氧化铝存在下进行。