Abstract:
The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.
Abstract:
A device (1) for detecting particles in air; said device (1) comprising: a receiver (10) for receiving a flow of air (12) comprising particles (2); a particle capturing arrangement (20) configured to transfer the particles (2) from the flow of air (12) to a liquid for collection of a set of particles (2) in the liquid; a flow channel (30) configured to pass a flow of the liquid comprising the set of particles (2) through the flow channel; a light source (40) configured to illuminate the set of particles (2) in the flow channel, such that an interference pattern is formed by interference between light being scattered by the set of particles (2) and non-scattered light from the light source; and an image sensor (50) comprising a plurality of photo-sensitive elements (52) configured to detect incident light, the image sensor (50) being configured to detect the interference pattern.
Abstract:
A collector (60, 90, 100) for collecting particles (2) in air, said collector (60, 90, 100) comprising: a substrate (61), which is adapted to enable imaging of the particles (2); an adhesive layer (65) arranged on a collector side (62) of the substrate (61), said adhesive layer (65) being formed by an adhesive material; a protection element (67), which is configured to protect the adhesive layer (65) before collection of particles (2); wherein the collector (60, 90, 100) is configured to allow release of protection of the adhesive layer (65) by the protection element (67) to expose an adhesive surface (66) of the adhesive layer (65) to ambient air for collecting particles (2) on the adhesive surface (66); and wherein the collector (60, 90, 100) is further configured for presenting a particle sample carrier (70) having a smooth top surface (68) and a smooth bottom surface (69) for preventing light from being diffusely scattered by the particle sample carrier (70).
Abstract:
An imaging device for in-line holographic imaging of an object (110) comprises: a set of light sources (102), wherein each light source (102) is configured to output light in a confined illumination cone; an image sensor (120), which comprises a set of light-detecting elements (122) for detecting incident light, wherein the set of light sources (102) are configured to output light such that the confined illumination cone of each light source (102) illuminates a specific part of the object (110); and wherein the light-detecting elements (122) detect a plurality of interference patterns, wherein each interference pattern is formed by diffracted light from the object (110) originating from a single light source (102) and undiffracted light from the same single light source (102), wherein at least a sub-set of light-detecting elements (122) is arranged to detect light relating to not more than one interference pattern.
Abstract:
A device (1) for detecting particles (2) in air; said device (1) comprising: a flow channel (30), wherein the flow channel (30) is configured to allow a flow of air (12) comprising particles (2) through the flow channel (30); a light source (40) configured to illuminate the particles (2) in the flow of air (12), such that an interference pattern is formed by interference between light being scattered by the particles (2) and non-scattered light from the light source (40); an image sensor (50) configured to detect incident light, the image sensor (50) being configured to detect the interference pattern, and wherein the image sensor (50) is configured to acquire a time-sequence of image frames, each image frame comprising a plurality of pixels, each pixel representing a detected intensity of light; and a frame processor (70) configured to filter information in the time-sequence of image frames, wherein said filtering comprises: identifying pixels of interest in the time-sequence of image frames, said pixels of interest picturing an interference pattern potentially representing a particle (2) in the flow of air (12), and outputting said identified pixels of interest for performing digital holographic reconstruction on the identified pixels of interest.
Abstract:
Embodiments described herein relate to a large area lens-free imaging device. One example is a lens-free device for imaging one or more objects. The lens-free device includes a light source positioned for illuminating at least one object. The lens-free device also includes a detector positioned for recording interference patterns of the illuminated at least one object. The light source includes a plurality of light emitters that are positioned and configured to create a controlled light wavefront for performing lens-free imaging.
Abstract:
The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.
Abstract:
A device in, and system for, holographic imaging comprising: at least two light sources (102, 104, 106; 202, 204; 302, 304; 402, 404), wherein each of the at least two light sources is arranged to output light of a unique wavelength; and at least one holographic optical element (110; 208; 308; 410, 412, 414), wherein the at least two light sources and the at least one holographic optical element are arranged in relation to each other such that light from the at least two light sources incident on the at least one holographic optical element is diffractively diverted by the at least one holographic optical element to form wavefronts of similar and registered shape onto an image sensor (114, 210, 312).