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公开(公告)号：EP3624832A1
公开(公告)日：2020-03-25
申请号：EP18724555.0
申请日：2018-05-15
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7 , Université Paris XIII Paris-Nord , Assistance Publique-Hôpitaux de Paris (APHP) , Fondation Ophthalmologique Adolphe De Rothschild
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公开(公告)号：EP3156078B1
公开(公告)日：2020-03-04
申请号：EP16191071.6
申请日：2009-04-10
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3.发明公开
公开(公告)号：EP2416806A1
公开(公告)日：2012-02-15
申请号：EP09786466.4
申请日：2009-04-10
发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain
CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534
摘要： The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.
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4.发明公开AGENTS FOR THE MOLECULAR IMAGING OF SERINE-PROTEASE IN HUMAN PATHOLOGIES 审中-公开代理商人类病理检查对丝氨酸蛋白酶的分子成像
公开(公告)号：EP2646058A1
公开(公告)日：2013-10-09
申请号：EP11794452.0
申请日：2011-12-05
发明人： MICHEL, Jean-Baptiste , ROUZET, François , LEGULUDEC, Dominique , PORAS, Hervé , FOURNIE-ZALUSKI, Marie-Claude , ROQUES, Bernard
CPC分类号： A61K51/088 , A61K49/0004 , A61K49/14 , A61K51/048 , A61K51/0482 , A61K51/08 , C07K5/1024
摘要： The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-PA) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.
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5.发明授权FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES 有权FUCOIDANE ALS LIGANDEN ZUR DIAGNOSE VON DEGENERATIVEN PATHOLOGIEN
公开(公告)号：EP2416806B8
公开(公告)日：2017-03-15
申请号：EP09786466.4
申请日：2009-04-10
发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/22 , A61K51/04 , A61K51/00 , A61K49/12 , A61K49/18 , A61K51/06 , B82Y5/00 , A61K103/10 , G01N33/60
CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534
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公开(公告)号：EP3432910A1
公开(公告)日：2019-01-30
申请号：EP17712144.9
申请日：2017-03-21
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7.发明公开AMINOFUCOIDAN AS A VECTOR FOR FIBRINOLYSIS IN THROMBOTIC DISEASES 审中-公开AMINOFUCOIDAN ALS VEKTOR ZUR FIBRINOLYSE BEI THROMBOTISCHEN ERKRANKUNGEN
公开(公告)号：EP2976099A1
公开(公告)日：2016-01-27
申请号：EP14715449.6
申请日：2014-03-21
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE PARIS 13 PARIS NORD , Université Paris Diderot (Paris 7)
发明人： LOYAU, Stéphane , JANDROT-PERRUS, Martine , LETOURNEUR, Didier , CHAUBET, Frédéric , HO-TIN-NOE, Benoît , MAIRE, Murielle , MICHEL, Jean-Baptiste
CPC分类号： A61K47/61 , A61K31/715 , A61K31/716 , A61K31/737 , A61K38/49 , A61K45/06 , A61K47/542 , A61K47/543 , A61K47/60 , C08B37/0006 , C12Y304/21068 , A61K2300/00
摘要： The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently linked to one or more t-PA binding amino groups by the reducing end of the said fucoidan moiety.
摘要翻译： 本发明涉及一种靶向血栓的载体，其具有由血栓靶向岩藻依聚糖部分组成的t-PA结合性质，其通过所述岩藻依聚糖部分的还原端与一个或多个t-PA结合氨基共价连接。
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公开(公告)号：EP2976099B1
公开(公告)日：2018-08-01
申请号：EP14715449.6
申请日：2014-03-21
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE PARIS 13 PARIS NORD , Université Paris Diderot (Paris 7)
发明人： LOYAU, Stéphane , JANDROT-PERRUS, Martine , LETOURNEUR, Didier , CHAUBET, Frédéric , HO-TIN-NOE, Benoît , MAIRE, Murielle , MICHEL, Jean-Baptiste
CPC分类号： A61K47/61 , A61K31/715 , A61K31/716 , A61K31/737 , A61K38/49 , A61K45/06 , A61K47/542 , A61K47/543 , A61K47/60 , C08B37/0006 , C12Y304/21068 , A61K2300/00
摘要： The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently linked to one or more t-PA binding amino groups by the reducing end of the said fucoidan moiety.
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