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1.发明公开
公开(公告)号：EP1660682A2
公开(公告)日：2006-05-31
申请号：EP04781089.0
申请日：2004-08-12
发明人： MONIA, Brett P. , DOBIE, Kenneth W. , FREIER, Susan M. , POPOFF, Ian , WONG, Wai Shiu Fred , KARRAS, James G.
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
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公开(公告)号：EP1268507A1
公开(公告)日：2003-01-02
申请号：EP01916307.0
申请日：2001-03-01
CPC分类号： C12N15/113 , A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcription factor 1. Methods of using these compounds for modulation of E2F transcription factor 1 expression and for treatment of diseases associated with expression of E2F transcription factor 1 are provided.
摘要翻译： 提供了用于调节E2F转录因子1的表达的反义化合物，组合物和方法。所述组合物包含靶向编码E2F转录因子1的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节E2F转录因子1 表达和用于治疗与E2F转录因子1表达相关的疾病。
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3.发明公开
公开(公告)号：EP1165593A1
公开(公告)日：2002-01-02
申请号：EP00920053.6
申请日：2000-04-04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.
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4.发明授权
公开(公告)号：EP1660682B1
公开(公告)日：2011-10-05
申请号：EP04781089.0
申请日：2004-08-12
发明人： MONIA, Brett P. , DOBIE, Kenneth W. , FREIER, Susan M. , POPOFF, Ian , WONG, Wai Shiu Fred , KARRAS, James G.
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
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5.发明公开ANTISENSE MODULATION OF E2F TRANSCRIPTION FACTOR 3 EXPRESSION 审中-公开防伪MODERIERUNG DER E2F TRANSKRIPTIONS FAKTOR 3 EXPRESSION
公开(公告)号：EP1257669A1
公开(公告)日：2002-11-20
申请号：EP01912869.3
申请日：2001-02-21
发明人： POPOFF, Ian , WYATT, Jacqueline, R.
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcription factor 3. Methods of using these compounds for modulation of E2F transcription factor 3 expression and for treatment of diseases associated with expression of E2F transcription factor 3 are provided.
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