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    ORTHOGONAL DEBLOCKING OF NUCLEOTIDES
    5.
    发明公开
    ORTHOGONAL DEBLOCKING OF NUCLEOTIDES 审中-公开

    公开(公告)号：EP3329007A1

    公开(公告)日：2018-06-06

    申请号：EP16739665.4

    申请日：2016-07-08

    申请人： Illumina, Inc.

    发明人： TREPAGNIER, Eliane H. ,  KHURANA, Tarun

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6874 ,  C12Q2523/107 ,  C12Q2525/155 ,  C12Q2525/186 ,  C12Q2523/313

    摘要： A method including steps of (a) providing an array of sites, wherein each site comprises a mixture of different nucleic acid templates; (b) extending primers hybridized to the different nucleic acid templates at each of the sites with different nucleotide analogs having different reversible blocking moieties, respectively, thereby producing different primer extension products at each site; (c) detecting the different primer extension products to distinguish the different nucleotide analogs at each site; and (d) removing the different reversible blocking moieties from the primer extension products at each of the sites using a first treatment that is selective for a first of the different reversible blocking moieties and a second treatment that is selective for a second of the different reversible blocking moieties.

    DEVICE WITH REDUCED FLUORESCENCE RANGE NOISE AND METHOD
    7.
    发明公开
    DEVICE WITH REDUCED FLUORESCENCE RANGE NOISE AND METHOD 审中-公开

    公开(公告)号：EP3978908A1

    公开(公告)日：2022-04-06

    申请号：EP21208877.7

    申请日：2018-11-30

    申请人： Illumina, Inc.

    发明人： FUNG, Tracy, H ,  SABOUNCHI, Poorya ,  HIRSCHBEIN, Bernard ,  PINTO, Joseph ,  KHURANA, Tarun ,  SMITH, Randall ,  FENG, Wenyi

    IPC分类号： G01N21/64 ,  G02B5/22 ,  H01L27/146 ,  G02B19/00

    摘要： A device comprising: a structure (260) defining a detector surface (206) for supporting biological or chemical samples; a sensor array (201) comprising light sensors (202), and circuitry to transmit data signals based on photons detected by the light sensors (202); and a guide array comprising light guides (214); wherein light guides (214) of the guide array receive excitation light (101) and
    emissions signal light (501) from the detector surface (206), wherein the light guides (214) extend toward respective light sensors (202) of the sensor array (201) and comprise filter material that blocks the excitation light and permits the emissions signal light to propagate toward the respective light sensors (202), wherein the detector surface (206) includes a reaction recess (210), the reaction recess comprising an index of refraction and a dimension sufficient to cancel background light energy incident on the detector surface in a detection band of the sensor array. A method comprising steps for fabricating the device.