公开(公告)号：EP3607950A3

公开(公告)日：2020-03-18

申请号：EP19184535.3

申请日：2015-03-13

申请人： Indiana University Research & Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A61K31/554

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3607950A2

公开(公告)日：2020-02-12

申请号：EP19184535.3

申请日：2015-03-13

申请人： Indiana University Research & Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A61K31/554

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3116316A1

公开(公告)日：2017-01-18

申请号：EP15761201.1

申请日：2015-03-13

申请人： Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W. ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A01N43/00 ,  A61K31/55 ,  C07D498/00

CPC分类号： C07D417/12 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D223/20 ,  C07D243/38 ,  C07D281/14 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

摘要翻译： 本公开部分提供对乙型肝炎病毒Cp具有变构效应子特性的化合物。 本文还提供了治疗病毒感染（例如乙型肝炎）的方法，其包括向有需要的患者施用所公开的化合物。

公开(公告)号：EP3974426A1

公开(公告)日：2022-03-30

申请号：EP21191660.6

申请日：2015-03-13

申请人： Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： C07D417/12 ,  C07D403/12 ,  A61K31/554 ,  A61P1/16 ,  A61P31/20

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3116316B1

公开(公告)日：2019-07-10

申请号：EP15761201.1

申请日：2015-03-13

申请人： Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W. ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A01N43/00 ,  A61K31/55 ,  C07D498/00

公开(公告)号：EP3139954A1

公开(公告)日：2017-03-15

申请号：EP15788791.0

申请日：2015-05-11

申请人： Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

发明人： ZLOTNICK, Adam ,  TURNER, William W. ,  ARNOLD, Lee Daniel

IPC分类号： A61K39/29 ,  A61K45/06 ,  G01N33/576

CPC分类号： A61K31/5377 ,  A61K31/18 ,  A61K31/445 ,  A61K31/506 ,  A61K31/713 ,  A61K45/06 ,  G01N33/5023 ,  G01N33/5032 ,  G01N33/5762 ,  G01N2500/04

摘要： Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.

摘要翻译： 本文描述了用于鉴定可用于治疗乙型肝炎病毒（HBV）感染的化合物和鉴定对其有用的化合物的方法。