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公开(公告)号：EP3974426A1
公开(公告)日：2022-03-30
申请号：EP21191660.6
申请日：2015-03-13
IPC分类号： C07D417/12 , C07D403/12 , A61K31/554 , A61P1/16 , A61P31/20
摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号：EP3116316B1
公开(公告)日：2019-07-10
申请号：EP15761201.1
申请日：2015-03-13
IPC分类号： A01N43/00 , A61K31/55 , C07D498/00
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3.发明公开METHODS AND COMPOSITIONS FOR TREATING HEPATITIS B VIRUS INFECTIONS 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON HEPATITIS-B-VIRENINFEKTIONEN
公开(公告)号：EP3139954A1
公开(公告)日：2017-03-15
申请号：EP15788791.0
申请日：2015-05-11
IPC分类号： A61K39/29 , A61K45/06 , G01N33/576
CPC分类号： A61K31/5377 , A61K31/18 , A61K31/445 , A61K31/506 , A61K31/713 , A61K45/06 , G01N33/5023 , G01N33/5032 , G01N33/5762 , G01N2500/04
摘要： Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
摘要翻译： 本文描述了用于鉴定可用于治疗乙型肝炎病毒（HBV）感染的化合物和鉴定对其有用的化合物的方法。
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4.发明公开HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS 审中-公开ALLOSTERISCHE MODULATOREN DES HEPATITIS-B-KERNPROTEINS
公开(公告)号：EP3116316A1
公开(公告)日：2017-01-18
申请号：EP15761201.1
申请日：2015-03-13
IPC分类号： A01N43/00 , A61K31/55 , C07D498/00
CPC分类号： C07D417/12 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K45/06 , C07D223/20 , C07D243/38 , C07D281/14 , C07D281/16 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
摘要翻译： 本公开部分提供对乙型肝炎病毒Cp具有变构效应子特性的化合物。 本文还提供了治疗病毒感染（例如乙型肝炎）的方法，其包括向有需要的患者施用所公开的化合物。
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公开(公告)号：EP3607950A2
公开(公告)日：2020-02-12
申请号：EP19184535.3
申请日：2015-03-13
IPC分类号： A61K31/554
摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号：EP3607950A3
公开(公告)日：2020-03-18
申请号：EP19184535.3
申请日：2015-03-13
IPC分类号： A61K31/554
摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号：EP3782626A1
公开(公告)日：2021-02-24
申请号：EP20185808.1
申请日：2016-09-15
发明人： TURNER, William , ARNOLD, Lee Daniel , MAAG, Hans , LI, Leping , BURES, Mark , HAYDAR, Simon , FRANCIS, Samson
IPC分类号： A61K31/554 , C07D281/16 , C07D417/12 , C07D417/14 , C07D413/12
摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号：EP3283472A1
公开(公告)日：2018-02-21
申请号：EP16780846.8
申请日：2016-04-15
IPC分类号： C07D401/04 , A01N43/54
CPC分类号： C07D403/14 , A61K31/496 , A61K31/506 , A61P31/20 , C07D213/74 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
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