公开(公告)号：EP3607950A3

公开(公告)日：2020-03-18

申请号：EP19184535.3

申请日：2015-03-13

申请人： Indiana University Research & Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A61K31/554

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3607950A2

公开(公告)日：2020-02-12

申请号：EP19184535.3

申请日：2015-03-13

申请人： Indiana University Research & Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A61K31/554

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3782626A1

公开(公告)日：2021-02-24

申请号：EP20185808.1

申请日：2016-09-15

申请人： Assembly Biosciences, Inc. ,  Indiana University Research & Technology Corporation

发明人： TURNER, William ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  LI, Leping ,  BURES, Mark ,  HAYDAR, Simon ,  FRANCIS, Samson

IPC分类号： A61K31/554 ,  C07D281/16 ,  C07D417/12 ,  C07D417/14 ,  C07D413/12

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3283472A1

公开(公告)日：2018-02-21

申请号：EP16780846.8

申请日：2016-04-15

申请人： Indiana University Research & Technology Corporation ,  Assembly Biosciences, Inc.

发明人： ARNOLD, Lee Daniel ,  MAAG, Hans ,  TURNER, JR., William W.

IPC分类号： C07D401/04 ,  A01N43/54

CPC分类号： C07D403/14 ,  A61K31/496 ,  A61K31/506 ,  A61P31/20 ,  C07D213/74 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

摘要： Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

公开(公告)号：EP3349581A1

公开(公告)日：2018-07-25

申请号：EP16847305.6

申请日：2016-09-15

申请人： Assembly Biosciences, Inc. ,  Indiana University Research and Technology Corporation

发明人： TURNER, William ,  MAAG, Hans ,  FRANCIS, Samson

IPC分类号： A01N57/00

CPC分类号： C07D417/12 ,  A61K45/06 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3974426A1

公开(公告)日：2022-03-30

申请号：EP21191660.6

申请日：2015-03-13

申请人： Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： C07D417/12 ,  C07D403/12 ,  A61K31/554 ,  A61P1/16 ,  A61P31/20

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3116316B1

公开(公告)日：2019-07-10

申请号：EP15761201.1

申请日：2015-03-13

申请人： Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

发明人： TURNER, William W. ,  ARNOLD, Lee Daniel ,  MAAG, Hans ,  ZLOTNICK, Adam

IPC分类号： A01N43/00 ,  A61K31/55 ,  C07D498/00

公开(公告)号：EP3349761A1

公开(公告)日：2018-07-25

申请号：EP16847298.3

申请日：2016-09-15

申请人： Assembly Biosciences, Inc. ,  Indiana University Research and Technology Corporation

发明人： TURNER, William ,  ARNOLD, Lee, Daniel ,  MAAG, Hans ,  BURES, Mark

IPC分类号： A61K31/554 ,  C07D281/16 ,  C07D417/12

CPC分类号： C07D417/12 ,  A61K45/06 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP3512845A1

公开(公告)日：2019-07-24

申请号：EP17772267.5

申请日：2017-09-14

申请人： Assembly Biosciences, Inc.

发明人： TURNER, William ,  ARNOLD, Lee, Daniel ,  LI, Leping ,  BURES, Mark ,  HAYDAR, Simon ,  MAAG, Hans ,  BANNEN, Lynne

IPC分类号： C07D417/12 ,  C07D513/04 ,  C07D487/04

公开(公告)号：EP3349580B1

公开(公告)日：2020-08-19

申请号：EP16847295.9

申请日：2016-09-15

申请人： Assembly Biosciences, Inc. ,  Indiana University Research and Technology Corporation

发明人： TURNER, William ,  ARNOLD, Lee, Daniel ,  MAAG, Hans ,  LI, Leping ,  BURES, Mark ,  HAYDAR, Simon ,  FRANCIS, Samson

IPC分类号： C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D243/38 ,  C07D453/02 ,  C07D471/04 ,  C07D267/20 ,  C07D281/16 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P31/20