公开(公告)号：EP0402699A3

公开(公告)日：1991-01-30

申请号：EP90110198.0

申请日：1990-05-30

申请人： MILES INC.

发明人： Corey, Paul F.

IPC分类号： C07H15/26 ,  C07H17/00 ,  C12Q1/34

CPC分类号： C07F9/6536 ,  C07D267/18 ,  C07D281/14 ,  C07F9/6527 ,  C07H17/00 ,  C12Q1/34 ,  C12Q2334/00 ,  G01N2333/924

摘要： Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e][1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.

公开(公告)号：EP1021190B1

公开(公告)日：2006-11-08

申请号：EP98942140.9

申请日：1998-08-20

申请人： KAKEN PHARMACEUTICAL CO., LTD. ,  Molecular Research Institute

发明人： FUNAMIZU, Hidenori ,  ISHIYAMA, Nobuo ,  IKEGAMI, Satoru, Centr. Res. Inst. Kaken Pharm. ,  OKUNO, Tadashi, Centr. Res. Inst. Kaken Pharm. ,  INOGUCHI, Kiyoshi, Centr. Res. Inst. Kaken Pharm. ,  HUANG, Ping, Molecular Research Institute ,  LOEW, Gilda H., Molecular Research Institute

IPC分类号： A61K31/55 ,  C07D267/14 ,  C07D267/16 ,  C07D281/10 ,  C07D223/16 ,  C07K5/02 ,  C07D403/12 ,  A61P5/00

CPC分类号： C07D223/16 ,  C07C237/22 ,  C07C2602/12 ,  C07D209/38 ,  C07D209/52 ,  C07D211/22 ,  C07D215/06 ,  C07D215/227 ,  C07D215/56 ,  C07D223/20 ,  C07D225/06 ,  C07D225/08 ,  C07D243/10 ,  C07D243/12 ,  C07D243/14 ,  C07D265/36 ,  C07D267/14 ,  C07D267/18 ,  C07D279/16 ,  C07D279/26 ,  C07D281/10 ,  C07D281/14 ,  C07D401/04 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

摘要： Disclosed are the novel compounds represented by structural Formula (I), wherein A is a lipophilic group comprising an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.

摘要翻译： 结构式（I）的化合物，其中A是包含脂族桥基的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性

公开(公告)号：EP1021190A4

公开(公告)日：2004-08-18

申请号：EP98942140

申请日：1998-08-20

申请人： KAKEN PHARMA CO LTD ,  MOLECULAR RES INST

发明人： FUNAMIZU HIDENORI ,  ISHIYAMA NOBUO ,  IKEGAMI SATORU ,  OKUNO TADASHI ,  INOGUCHI KIYOSHI ,  HUANG PING ,  LOEW GILDA H

IPC分类号： C07D243/12 ,  A61K31/395 ,  A61K31/403 ,  A61K31/404 ,  A61K31/47 ,  A61K31/535 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5517 ,  A61K31/553 ,  A61K31/554 ,  A61K38/00 ,  A61P5/06 ,  A61P17/02 ,  A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P37/00 ,  A61P43/00 ,  C07D209/38 ,  C07D209/42 ,  C07D215/06 ,  C07D215/22 ,  C07D223/16 ,  C07D223/20 ,  C07D225/06 ,  C07D225/08 ,  C07D243/24 ,  C07D265/36 ,  C07D267/14 ,  C07D267/20 ,  C07D279/16 ,  C07D281/10 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  C07K5/06 ,  A61P5/00 ,  C07D267/16 ,  C07K5/02

CPC分类号： C07D223/16 ,  C07C237/22 ,  C07C2602/12 ,  C07D209/38 ,  C07D209/52 ,  C07D211/22 ,  C07D215/06 ,  C07D215/227 ,  C07D215/56 ,  C07D223/20 ,  C07D225/06 ,  C07D225/08 ,  C07D243/10 ,  C07D243/12 ,  C07D243/14 ,  C07D265/36 ,  C07D267/14 ,  C07D267/18 ,  C07D279/16 ,  C07D279/26 ,  C07D281/10 ,  C07D281/14 ,  C07D401/04 ,  C07D403/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

公开(公告)号：EP0402699A2

公开(公告)日：1990-12-19

申请号：EP90110198.0

申请日：1990-05-30

申请人： MILES INC.

发明人： Corey, Paul F.

IPC分类号： C07H15/26 ,  C07H17/00 ,  C12Q1/34

CPC分类号： C07F9/6536 ,  C07D267/18 ,  C07D281/14 ,  C07F9/6527 ,  C07H17/00 ,  C12Q1/34 ,  C12Q2334/00 ,  G01N2333/924

摘要： Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e][1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.

摘要翻译： 包含具有酶切割基团的二苯并[b，e] [1,4]氧氮杂酮或二苯并[b，e] [1,4]噻吩酮核的显色酶底物化合物，例如糖，羧酸，氨基 酸，肽，磷酸或硫酸。 底物化合物通常在水性介质中高度可溶，仅稍微着色，并且在酶切割时产生显示出吸光度变化大的显色剂和低于7的pKa。这样的底物可用作测定酶的指示剂 分析物和酶用于各种测定中的标记，包括免疫测定。

公开(公告)号：EP3116316A4

公开(公告)日：2018-05-23

申请号：EP15761201

申请日：2015-03-13

申请人： INDIANA UNIV RESEARCH AND TECHNOLOGY CORPORATION ,  ASSEMBLY BIOSCIENCES INC

发明人： TURNER WILLIAM W ,  ARNOLD LEE DANIEL ,  MAAG HANS ,  ZLOTNICK ADAM

IPC分类号： A01N43/00 ,  A61K31/55 ,  C07D498/00

CPC分类号： C07D417/12 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D223/20 ,  C07D243/38 ,  C07D281/14 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：EP0679641B1

公开(公告)日：2002-10-02

申请号：EP94921819.2

申请日：1994-07-26

申请人： Eisai Co., Ltd.

发明人： YOSHINO, Hiroshi ,  UEDA, Norihiro 1077-140, Yatabe ,  NIIJIMA, Jun 14-10-B-202, Matsuhiro 1-chome ,  HANEDA, Toru 9-24-1003, Chuo 2-chome ,  KOTAKE, Yoshihiko ,  YOSHIMATSU, Kentaro ,  WATANABE, Tatsuo ,  NAGASU, Takeshi 852-13, Nagakuni ,  TSUKAHARA, Naoko 796-2-101, Shibazaki ,  KOYANAGI, Nozomu 10-15, Toukoudai 1-chome ,  KITOH, Kyosuke 10-8, Toukoudai 1-chome

IPC分类号： C07D209/88 ,  C07D219/08 ,  C07D223/22 ,  C07D241/46 ,  C07D243/38 ,  C07D253/06 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/14 ,  C07D279/20 ,  C07D221/12 ,  C07D281/14 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D219/04 ,  C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D513/04 ,  C07F7/1856

公开(公告)号：EP0679641A4

公开(公告)日：1996-03-20

申请号：EP94921819

申请日：1994-07-26

申请人： EISAI CO LTD

发明人： YOSHINO HIROSHI ,  UEDA NORIHIRO ,  NIIJIMA JUN ,  HANEDA TORU ,  KOTAKE YOSHIHIKO ,  YOSHIMATSU KENTARO ,  WATANABE TATSUO ,  NAGASU TAKESHI ,  TSUKAHARA NAOKO ,  KOYANAGI NOZOMU ,  KITO KYOSUKE

IPC分类号： C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/04 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D498/04 ,  C07D513/04 ,  C07F7/18 ,  C07D241/46 ,  C07D253/06 ,  C07D279/14

CPC分类号： C07D219/04 ,  C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D513/04 ,  C07F7/1856

摘要： Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents O or NR1, wherein R1 represents hydrogen or lower alkyl; and M represents a tricyclic structure selected from the members (a), (b), (c), (d), (e), (f), wherein rings A and B represent each a 5- or 6-membered unsaturated ring; X represents NR2 (wherein R2 represents hydrogen or lower alkyl) or NHCO; Y represents O, S(O)¿n?, CR?3R4¿, CO, NR?5, CHR6CHR7, CR8=CR9, NR10¿CO, N=CR?11, OCHR12¿, S(O)¿n?CHR?13 or NR14CHR15¿; and Z represents N or CR16, wherein n represents 0, 1 or 2; R?3-R13, R15 and R16¿ represent each hydrogen or lower alkyl; and R14 represents hydrogen, lower alkyl or lower acyl.

公开(公告)号：EP0679641A1

公开(公告)日：1995-11-02

申请号：EP94921819.2

申请日：1994-07-26

申请人： Eisai Co., Ltd.

发明人： YOSHINO, Hiroshi ,  UEDA, Norihiro 1077-140, Yatabe ,  NIIJIMA, Jun 14-10-B-202, Matsuhiro 1-chome ,  HANEDA, Toru 9-24-1003, Chuo 2-chome ,  KOTAKE, Yoshihiko ,  YOSHIMATSU, Kentaro ,  WATANABE, Tatsuo ,  NAGASU, Takeshi 852-13, Nagakuni ,  TSUKAHARA, Naoko 796-2-101, Shibazaki ,  KOYANAGI, Nozomu 10-15, Toukoudai 1-chome ,  KITOH, Kyosuke 10-8, Toukoudai 1-chome

IPC分类号： C07D209/88 ,  C07D219/08 ,  C07D223/22 ,  C07D241/46 ,  C07D243/38 ,  C07D253/06 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/14 ,  C07D279/20 ,  C07D221/12 ,  C07D281/14 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D219/04 ,  C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D513/04 ,  C07F7/1856

摘要： Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents O or NR¹, wherein R¹ represents hydrogen or lower alkyl; and M represents a tricyclic structure selected from the members (a), (b), (c), (d), (e), (f), wherein rings A and B represent each a 5- or 6-membered unsaturated ring; X represents NR² (wherein R² represents hydrogen or lower alkyl) or NHCO; Y represents O, S(O) n , CR³R⁴, CO, NR⁵, CHR⁶CHR⁷, CR⁸=CR⁹, NR¹⁰CO, N=CR¹¹, OCHR¹², S(O) n CHR¹³ or NR¹⁴CHR¹⁵; and Z represents N or CR¹⁶, wherein n represents 0, 1 or 2; R³-R¹³, R¹⁵ and R¹⁶ represent each hydrogen or lower alkyl; and R¹⁴ represents hydrogen, lower alkyl or lower acyl.

摘要翻译： 具有由通式（I）表示的三环杂环的新型抗肿瘤磺酰胺和磺酸酯衍生物及其制备方法，其中G表示5-或6-元芳香环; L表示O或NR 1，其中R 1表示氢或低级烷基; 并且M表示选自成员（a），（b），（c），（d），（e），（f））的三环结构，其中环A和B各自表示5-或6-元不饱和环 ; X表示NR 2（其中R 2表示氢或低级烷基）或NHCO; Y表示O，S（O）n，CR 3 R 4，CO，NR 5，CHR 6 CHR 7，CR 8 = CR 9，NR 1， CO，N = CR 1，OCHR 1，S（O）n CHR 1或NR 1 CHR 1 5。 Z表示N或CR 1，其中n表示0,1或2; R 3 -R 1，R 5和R 6代表每个氢或低级烷基; R 1表示氢，低级烷基或低级酰基。

公开(公告)号：EP1578198A1

公开(公告)日：2005-09-28

申请号：EP03782439.8

申请日：2003-12-18

申请人： BASF Aktiengesellschaft

发明人： STEINER, Gerd ,  SCHMIDT, Thomas ,  KORDES, Markus ,  VON DEYN, Wolfgang ,  GÖTZ, Norbert ,  HOFMANN, Michael ,  DE KRAMER, Jacobus Jan ,  HEFFERNAN, Gavin ,  CULBERTSON, Deborah L. ,  TREACY, Michael, F. ,  OLOUMI-SADEGHI, Hassan ,  EBUENGA, Cecille ,  TEDESCHI, Livio ,  BUCCI, Toni ,  PARRA RAPADO, Liliana ,  RACK, Michael ,  BAUMANN, Ernst ,  PUHL, Michael

IPC分类号： A01N43/72 ,  A01N43/62 ,  A01N43/34 ,  C07D223/20 ,  C07D281/14 ,  C07D267/18 ,  C07D243/38

CPC分类号： C07D267/20 ,  A01N43/72 ,  C07D223/20 ,  C07D243/38 ,  C07D267/18 ,  C07D281/14 ,  C07D281/16 ,  C07D413/12

摘要： Use of compounds of formula (I): wherein X is S, O, S=O, SO2, NRa, or CRbRc;R1,R2 are halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenyl, alkenyloxy, alkenylamino, alkenylthio, alkynyl, alkynyloxy, alkynylamino, alkynylthio, alkylsulfonyl, alkylsulfoxyl, alkenylsulfonyl, alkynylsulfoxyl, formyl, alkylcarbonyl, hydroxycarbonyl, alkoxycarbonyl, carbonyloxy, alkylcarbonyloxy, phenyloxy, alkylcarbonylamino, C(O)NRdRe, or (SO2)NRdRe, or C=NORf)-Gp-Rf', ora mono- or bicyclic 5- to 10-membered aromatic or heteroaromatic ringsystem, optionally substituted, which is unfused or fused to the aromatic group to which it is bonded and which, when unfused, is bonded directly or through an O, S, alkyl, or alkoxy linkage, or cycloalkyl, wherein the carbon atoms in these groups may be substituted.R3,R4 are each independently H, alkyl, haloalkyl, alkylamino, alkoxy, cycloalkyl, wherein the carbon atoms in these groups may be substituted, or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or partially saturated mono- or bicyclic 5- to 10-membered ringsystem or 5-membered hetaryl, phenyl or benzyl, wherein the rings are optionally sub-stituted, or R3 and R4 together form the chains -(CH2)2N+(O-)(CH2)2- or -(CH2)3N+(O-)(CH2)2-;and Ra, Rb, Rc, Rd, Re, Rf', Rf, G, and p are as defined in the description;m is 0, 1, 2, 3 or 4;n is 0, 1, 2, 3 or 4;or the enantiomers or diastereomers, salts or esters thereof for combatting insects, arachnids, or nematodes, methods for the control of these pests and of protecting growing plants from attack or infestation by these pests by applying a pesticidally effective amount of compounds of formula ( I), compounds of formula (I), processes for preparing them, and compositions comprising them.

公开(公告)号：EP1201663A4

公开(公告)日：2005-02-16

申请号：EP99929773

申请日：1999-07-09

申请人： UBE INDUSTRIES ,  ASTRAZENECA UK LTD

发明人： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  YOSHII KIYOTAKA

IPC分类号： C07D281/16 ,  A61K31/55 ,  A61K31/554 ,  A61P25/18 ,  C07C319/14 ,  C07C323/62 ,  C07B61/00

CPC分类号： C07D281/14 ,  C07C319/14 ,  C07C323/62 ,  C07D281/16

摘要： A process for producing dibenzothiazepine derivatives typified by dibenzo[b,f][1,4]thiazepin-11-one which are usable as the starting material for producing 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperazinyldibenzothiazepine derivatives useful as a psychotropic drug, which comprises reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the thus obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and then further dehydrating and condensing the thus obtained 2-amino-2'-carboxy-diphenylsulfide derivative.