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公开(公告)号：EP4158341A1
公开(公告)日：2023-04-05
申请号：EP21728199.7
申请日：2021-05-20
申请人： Institut national de recherche pour l'agriculture, l'alimentation et l'environnement , Centre national de la recherche scientifique , Universita' Degli Studi di Udine , Université Claude Bernard Lyon I
发明人： VIDIC, Jasmina , RAMA RAO, Nalini , CHAIX, Carole , FARRE, Carole , MANZANO, Marisa , VIZZINI, Priya
IPC分类号： G01N33/532 , G01N33/543 , G01N33/569
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2.发明公开DERIVES DU DIAMINOPHENOTHIAZINIUM POUR LE MARQUAGE DE BIOMOLECULES, PROCEDE ET SUPPORT DE MARQUAGE D'OLIGONUCLEOTIDES ET OLIGONUCLEOTIDES OBTENUS 有权DIAMINOPHENOTHIAZINDERIVATE用于标记的生物分子，用于标记OLIGONUCLEOTIDES方法及基板，从而获得OLIGONUCLEOTIDES
公开(公告)号：EP2820003A1
公开(公告)日：2015-01-07
申请号：EP13710497.2
申请日：2013-02-21
发明人： CHAIX, Carole , DE CROZALS, Gabriel
IPC分类号： C07D279/18 , C07H21/04 , C09B49/06
CPC分类号： C07F9/6547 , C07D279/18 , C07H1/00 , C07H21/00 , C09B21/00
摘要： The present invention relates to diaminophenothiazinium derivatives of formula (I); in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and X are as defined in Claim 1, and also the methods for labelling oligonucleotides using such a derivative, labelling substrates and the oligonucleotides which can be obtained by means of such methods or from such labelling substrates.-
3.发明授权DERIVES DU DIAMINOPHENOTHIAZINIUM POUR LE MARQUAGE DE BIOMOLECULES, PROCEDE ET SUPPORT DE MARQUAGE D'OLIGONUCLEOTIDES ET OLIGONUCLEOTIDES OBTENUS 有权DIAMINOPHENOTHIAZINDERIVATE用于标记的生物分子，用于标记OLIGONUCLEOTIDES方法及基板，从而获得OLIGONUCLEOTIDES
公开(公告)号：EP2820003B1
公开(公告)日：2016-08-10
申请号：EP13710497.2
申请日：2013-02-21
发明人： CHAIX, Carole , DE CROZALS, Gabriel
IPC分类号： C07D279/18 , C07H21/04 , C09B49/06 , C09B21/00 , C07F9/6547
CPC分类号： C07F9/6547 , C07D279/18 , C07H1/00 , C07H21/00 , C09B21/00
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4.发明公开MATERIAU POUR SYNTHESE SUPPORTEE ET PROCEDE DE CROISSANCE D'OLIGONUCLEOTIDES OU DE PEPTIDES 审中-公开材料进行繁殖寡核苷酸或肽支持的综合和方法
公开(公告)号：EP2731734A2
公开(公告)日：2014-05-21
申请号：EP12745892.5
申请日：2012-07-10
CPC分类号： C07K1/042 , B01J2219/00632 , B01J2219/00641 , B01J2219/00722 , B05D1/185 , B05D7/00 , B05D7/22 , B82Y30/00 , C07H21/00 , Y10T428/2982
摘要： The invention relates to a material formed by a porous support onto which functionalised nanoparticles are covalently grafted. The material is characterised in that: at least part of the covalently grafted nanoparticles are housed inside surface pores of the support; and the support is based on silica and takes the form of porous particles of heterogeneous shape and size, the particle size being greater than 1 μm and, preferably, between 5 and 200 μm. The invention also relates to a method for growing oligonucleotides or peptides, characterised in that: the oligonucleotides or peptides are grown on a material formed by a porous support onto which functionalised nanoparticles are covalently grafted, and at least part of the covalently grafted nanoparticles are housed inside surface pores of the support.
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5.发明公开COMPOSÉS THIOL ET LEUR UTILISATION POUR LA SYNTHÈSE D'OLIGONUCLÉOTIDES MODIFIÉS 有权硫醇化合物及其用于修饰的寡核苷酸的制造
公开(公告)号：EP2834253A1
公开(公告)日：2015-02-11
申请号：EP13713922.6
申请日：2013-04-04
申请人： Centre National de la Recherche Scientifique (CNRS) , Universite de Montpellier 1 , Etablissement Français du Sang , Université Claude Bernard Lyon 1
发明人： MORVAN, François , MEYER, Albert , VASSEUR, Jean-Jacques , MAYEN, Julie , CHAIX, Carole , FARRE, Carole , FOURNIER-WIRTH, Chantal , CANTALOUBE, Jean-François , LEREAU, Myriam
IPC分类号： C07F9/44
CPC分类号： C07H21/04 , C07C323/52 , C07F9/2408 , C08F257/02 , C12N15/11
摘要： The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.
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6.发明公开MONOMERES ELECTROPOLYMERISABLES SOLUBLES EN SOLUTION AQUEUSE ET SONDES ELECTROACTIVES SUSCEPTIBLES D'ETRE OBTENUES AVEC DE TELS MONOMERES 审中-公开在溶于水性溶液可电单体和电活性探针，这些单体的GET LEAVE
公开(公告)号：EP1907404A1
公开(公告)日：2008-04-09
申请号：EP06778815.8
申请日：2006-07-07
CPC分类号： C08G73/0611 , C07F17/02 , C08F2/10 , C08F2/16 , C08F2/52 , C08G61/124
摘要： The invention relates to an electropolymerisable monomer which is intended to be polymerised in aqueous solution, comprising a single electropolymerisable unit and an electron donor group. The invention is characterised in that it also comprises at least one arm that can be ionised in aqueous solution. The invention also relates to the polymerisation method, the electroactive probe thus obtained and the method of detecting a target ligand in a biological sample.
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7.发明授权COMPOSÉS THIOL ET LEUR UTILISATION POUR LA SYNTHÈSE D'OLIGONUCLÉOTIDES MODIFIÉS 有权维多利亚·德维森·祖尔·赫尔斯顿（VERWENDUNG DAVON ZUR HENTELLUNG VON MODIFIZIERTEN OLIGONUKLEOTIDEN）
公开(公告)号：EP2834253B1
公开(公告)日：2017-03-29
申请号：EP13713922.6
申请日：2013-04-04
申请人： Centre National de la Recherche Scientifique (C.N.R.S.) , Universite de Montpellier 1 , Etablissement Français du Sang , Université Claude Bernard Lyon 1
发明人： MORVAN, François , MEYER, Albert , VASSEUR, Jean-Jacques , MAYEN, Julie , CHAIX, Carole , FARRE, Carole , FOURNIER-WIRTH, Chantal , CANTALOUBE, Jean-François , LEREAU, Myriam
IPC分类号： C07F9/44
CPC分类号： C07H21/04 , C07C323/52 , C07F9/2408 , C08F257/02 , C12N15/11
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8.发明授权
公开(公告)号：EP2859008B1
公开(公告)日：2017-02-22
申请号：EP13716756.5
申请日：2013-04-04
申请人： Etablissement Français Du Sang (EFS) , Centre National de la Recherche Scientifique (C.N.R.S.) , Universite de Montpellier 1 , Université Claude Bernard Lyon 1
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9.发明公开
公开(公告)号：EP2859008A1
公开(公告)日：2015-04-15
申请号：EP13716756.5
申请日：2013-04-04
申请人： Etablissement Français Du Sang (EFS) , Centre National de la Recherche Scientifique (CNRS) , Universite de Montpellier 1 , Université Claude Bernard Lyon 1
发明人： FOURNIER-WIRTH, Chantal , LEREAU, Myriam , CANTALOUBE, Jean-François , VASSEUR, Jean-Jacques , MORVAN, François , MEYER, Albert , MAYEN, Julie , CHAIX, Carole , FARRE, Carole
摘要： The present invention concerns a modified oligonucleotide having two or a plurality of thiol functions, capable of being immobilised on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or one carbon-carbon triple bond or halogen acetamide functions, preferably maleimide or acrylamide functions. The invention also concerns a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridisation between a modified oligonucleotide and an amplified target nucleic acid from the biological sample. The invention more specifically concerns a method for detecting genotyping or sequencing of a pathogenic organism, preferably a virus.
摘要翻译： 本发明涉及一种具有两个或更多个巯基的功能，它可以在金表面或上的接枝表面上固定化的修饰寡核苷酸，特别是表面，其包括至少一个碳 - 碳双键或碳 - 碳三键或卤代乙酰胺 功能，优选马来酰亚胺或丙烯酰胺功能。 因此本发明涉及一种用于生物样品包含修饰寡核苷酸和靶核酸从生物样品扩增之间检测杂交的步骤中检测核酸的方法。 本发明更具体地涉及一种用于检测，基因分型或测序的病原生物，优选的病毒。
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