公开(公告)号：EP1907404A1

公开(公告)日：2008-04-09

申请号：EP06778815.8

申请日：2006-07-07

申请人： BIOMERIEUX ,  Centre National de la Recherche Scientifique

发明人： BOUCHET, Aurélie ,  CHAIX, Carole ,  MANDRAND, Bernard

IPC分类号： C07F17/02 ,  C08F2/16 ,  C08G73/06

CPC分类号： C08G73/0611 ,  C07F17/02 ,  C08F2/10 ,  C08F2/16 ,  C08F2/52 ,  C08G61/124

摘要： The invention relates to an electropolymerisable monomer which is intended to be polymerised in aqueous solution, comprising a single electropolymerisable unit and an electron donor group. The invention is characterised in that it also comprises at least one arm that can be ionised in aqueous solution. The invention also relates to the polymerisation method, the electroactive probe thus obtained and the method of detecting a target ligand in a biological sample.

公开(公告)号：EP2834253A1

公开(公告)日：2015-02-11

申请号：EP13713922.6

申请日：2013-04-04

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Universite de Montpellier 1 ,  Etablissement Français du Sang ,  Université Claude Bernard Lyon 1

发明人： MORVAN, François ,  MEYER, Albert ,  VASSEUR, Jean-Jacques ,  MAYEN, Julie ,  CHAIX, Carole ,  FARRE, Carole ,  FOURNIER-WIRTH, Chantal ,  CANTALOUBE, Jean-François ,  LEREAU, Myriam

IPC分类号： C07F9/44

CPC分类号： C07H21/04 ,  C07C323/52 ,  C07F9/2408 ,  C08F257/02 ,  C12N15/11

摘要： The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

公开(公告)号：EP2834253B1

公开(公告)日：2017-03-29

申请号：EP13713922.6

申请日：2013-04-04

申请人： Centre National de la Recherche Scientifique (C.N.R.S.) ,  Universite de Montpellier 1 ,  Etablissement Français du Sang ,  Université Claude Bernard Lyon 1

发明人： MORVAN, François ,  MEYER, Albert ,  VASSEUR, Jean-Jacques ,  MAYEN, Julie ,  CHAIX, Carole ,  FARRE, Carole ,  FOURNIER-WIRTH, Chantal ,  CANTALOUBE, Jean-François ,  LEREAU, Myriam

IPC分类号： C07F9/44

CPC分类号： C07H21/04 ,  C07C323/52 ,  C07F9/2408 ,  C08F257/02 ,  C12N15/11

公开(公告)号：EP2859008B1

公开(公告)日：2017-02-22

申请号：EP13716756.5

申请日：2013-04-04

申请人： Etablissement Français Du Sang (EFS) ,  Centre National de la Recherche Scientifique (C.N.R.S.) ,  Universite de Montpellier 1 ,  Université Claude Bernard Lyon 1

发明人： FOURNIER-WIRTH, Chantal ,  LEREAU, Myriam ,  CANTALOUBE, Jean-François ,  VASSEUR, Jean-Jacques ,  MORVAN, François ,  MEYER, Albert ,  MAYEN, Julie ,  CHAIX, Carole ,  FARRE, Carole

IPC分类号： C07H21/00 ,  C07H21/04 ,  G01N33/50

CPC分类号： C07H21/00 ,  C07H21/04 ,  C12Q1/707

公开(公告)号：EP2859008A1

公开(公告)日：2015-04-15

申请号：EP13716756.5

申请日：2013-04-04

申请人： Etablissement Français Du Sang (EFS) ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite de Montpellier 1 ,  Université Claude Bernard Lyon 1

发明人： FOURNIER-WIRTH, Chantal ,  LEREAU, Myriam ,  CANTALOUBE, Jean-François ,  VASSEUR, Jean-Jacques ,  MORVAN, François ,  MEYER, Albert ,  MAYEN, Julie ,  CHAIX, Carole ,  FARRE, Carole

IPC分类号： C07H21/00 ,  C07H21/04 ,  G01N33/50

CPC分类号： C07H21/00 ,  C07H21/04 ,  C12Q1/707

摘要： The present invention concerns a modified oligonucleotide having two or a plurality of thiol functions, capable of being immobilised on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or one carbon-carbon triple bond or halogen acetamide functions, preferably maleimide or acrylamide functions. The invention also concerns a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridisation between a modified oligonucleotide and an amplified target nucleic acid from the biological sample. The invention more specifically concerns a method for detecting genotyping or sequencing of a pathogenic organism, preferably a virus.

摘要翻译： 本发明涉及一种具有两个或更多个巯基的功能，它可以在金表面或上的接枝表面上固定化的修饰寡核苷酸，特别是表面，其包括至少一个碳 - 碳双键或碳 - 碳三键或卤代乙酰胺 功能，优选马来酰亚胺或丙烯酰胺功能。 因此本发明涉及一种用于生物样品包含修饰寡核苷酸和靶核酸从生物样品扩增之间检测杂交的步骤中检测核酸的方法。 本发明更具体地涉及一种用于检测，基因分型或测序的病原生物，优选的病毒。

公开(公告)号：EP2820003B1

公开(公告)日：2016-08-10

申请号：EP13710497.2

申请日：2013-02-21

申请人： Université Claude Bernard Lyon I ,  Centre National de la Recherche Scientifique (CNRS)

发明人： CHAIX, Carole ,  DE CROZALS, Gabriel

IPC分类号： C07D279/18 ,  C07H21/04 ,  C09B49/06 ,  C09B21/00 ,  C07F9/6547

CPC分类号： C07F9/6547 ,  C07D279/18 ,  C07H1/00 ,  C07H21/00 ,  C09B21/00

公开(公告)号：EP2731734A2

公开(公告)日：2014-05-21

申请号：EP12745892.5

申请日：2012-07-10

申请人： Université Claude Bernard Lyon I ,  Centre National de la Recherche Scientifique

发明人： CHAIX, Carole ,  DE CROZALS, Gabriel ,  FARRE, Carole

IPC分类号： B05D7/00 ,  C12Q1/68

CPC分类号： C07K1/042 ,  B01J2219/00632 ,  B01J2219/00641 ,  B01J2219/00722 ,  B05D1/185 ,  B05D7/00 ,  B05D7/22 ,  B82Y30/00 ,  C07H21/00 ,  Y10T428/2982

摘要： The invention relates to a material formed by a porous support onto which functionalised nanoparticles are covalently grafted. The material is characterised in that: at least part of the covalently grafted nanoparticles are housed inside surface pores of the support; and the support is based on silica and takes the form of porous particles of heterogeneous shape and size, the particle size being greater than 1 μm and, preferably, between 5 and 200 μm. The invention also relates to a method for growing oligonucleotides or peptides, characterised in that: the oligonucleotides or peptides are grown on a material formed by a porous support onto which functionalised nanoparticles are covalently grafted, and at least part of the covalently grafted nanoparticles are housed inside surface pores of the support.

公开(公告)号：EP4158341A1

公开(公告)日：2023-04-05

申请号：EP21728199.7

申请日：2021-05-20

申请人： Institut national de recherche pour l'agriculture, l'alimentation et l'environnement ,  Centre national de la recherche scientifique ,  Universita' Degli Studi di Udine ,  Université Claude Bernard Lyon I

发明人： VIDIC, Jasmina ,  RAMA RAO, Nalini ,  CHAIX, Carole ,  FARRE, Carole ,  MANZANO, Marisa ,  VIZZINI, Priya

IPC分类号： G01N33/532 ,  G01N33/543 ,  G01N33/569

公开(公告)号：EP2820003A1

公开(公告)日：2015-01-07

申请号：EP13710497.2

申请日：2013-02-21

申请人： Université Claude Bernard Lyon I ,  Centre National de la Recherche Scientifique (CNRS)

发明人： CHAIX, Carole ,  DE CROZALS, Gabriel

IPC分类号： C07D279/18 ,  C07H21/04 ,  C09B49/06

CPC分类号： C07F9/6547 ,  C07D279/18 ,  C07H1/00 ,  C07H21/00 ,  C09B21/00

摘要： The present invention relates to diaminophenothiazinium derivatives of formula (I); in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and X are as defined in Claim 1, and also the methods for labelling oligonucleotides using such a derivative, labelling substrates and the oligonucleotides which can be obtained by means of such methods or from such labelling substrates.

公开(公告)号：EP1578759A1

公开(公告)日：2005-09-28

申请号：EP03814482.0

申请日：2003-12-16

申请人： BIOMERIEUX SA

发明人： MANDRAND, Bernard ,  ZSOLDOS, Daniela ,  LAURENT, Alain ,  CHAIX, Carole ,  SPINELLI, Nicolas

IPC分类号： C07H21/00

CPC分类号： C07H21/00 ,  Y02P20/55

摘要： The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilise and address olionucleotides by electropolymerisation. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sample. (I) wherein, R1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from -(CH2) -O-, -(CH2)P O-[(CH2)2-O] q-, -(CH2)r; -CO-NR'-(CH2 )r-0-, -(CH2 )r-NCH3-(CH2 )r-O-, -(CH2)r CO-NR'-[(CH2)2 -O]s-, -(CH2)r NCH3-[(CH2)2-O]S-, R' is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r' is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r' and s are identical or different, a pyrrole cycle is substituted in a position 2,3 4, or 5.

摘要翻译： 本发明涉及式（I）的新型吡咯衍生物，其可以通过电聚合固定和解决寡核苷酸。 本发明还涉及如此生产的电活性聚合物和使用它们检测，鉴定和定量样品中分析物的方法。 （I）其中，R 1是一种寡核苷酸，Y是S或O，X是选自 - （CH 2）-O-， - （CH 2）P O - [（CH 2）2 -O] q- ， - （CH 2）r; （CH2）r-NCH3-（CH2）rO - ， - （CH2）rCO-NR' - [（CH2）2-O] s-， - （CH 2）r NCH 3 - [（CH 2）2 -O] S - ，R'为H或CH 3，n为1至5的整数，p为1至2的整数，q为整数 数字范围从1到4，r是范围从1到3的整数，r'是范围从1到3的整数，s是范围从1到3的整数，n，p，q，r，r '和s是相同的或不同的，吡咯环在2,3,4或5位取代。