公开(公告)号：EP2606242A1

公开(公告)日：2013-06-26

申请号：EP11818878.8

申请日：2011-08-20

申请人： Integenx Inc.

发明人： VANGBO, Mattias

IPC分类号： F15C3/04

CPC分类号： F16K99/0015 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2400/0638 ,  B01L2400/0655 ,  B33Y70/00 ,  B33Y80/00 ,  F04B19/006 ,  F04B43/043 ,  F16K99/0055 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0402 ,  Y10T137/7895

摘要： This invention provides a fluidic device comprising a diaphragm valve having a fluidics layer, an actuation layer and an elastic layer between the fluidics layer and the actuation layer, the elastic layer having a diaphragm that is mechanically sealed against the fluidics layer and the actuation layer by a sealing ring in the actuation layer.

摘要翻译： 本发明提供了一种流体装置，其包括具有流体层，致动层和在流体层和致动层之间的弹性层的隔膜阀，弹性层具有通过以下方式机械密封流体层和致动层的隔膜 致动层中的密封环。

公开(公告)号：EP3631005A1

公开(公告)日：2020-04-08

申请号：EP18805868.9

申请日：2018-05-22

申请人： Integenx Inc.

发明人： VANGBO, Mattias ,  KING, David ,  BARICAN, Arnaldo

IPC分类号： C12Q1/6806 ,  C12Q1/68 ,  C12Q1/00

公开(公告)号：EP3209410A1

公开(公告)日：2017-08-30

申请号：EP15851818.3

申请日：2015-10-21

申请人： IntegenX Inc.

发明人： KINDWALL, Alexander ,  PARK, Chungsoo, Charles ,  ILKOV, Fedor ,  JOVANOVICH, Stevan ,  KING, David ,  LITTLEHALE, Tristan, Robert ,  NILSON, David, Grant ,  PITTARO, Rick ,  SCHUEREN, Robert, A. ,  VANGBO, Mattias ,  WUNDERLE, Philip, Justus

IPC分类号： B01D59/42 ,  C25B11/02 ,  G01N27/447 ,  G01N27/49

CPC分类号： G01N27/44791 ,  B01L3/502715 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0421 ,  G01N27/44704 ,  G01N27/44743 ,  G01N27/44786 ,  G01N27/453

摘要： The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.

摘要翻译： 本公开提供了用于样品制备，处理和分析的系统和方法。 在本公开内容中还提供了一种完全集成的电泳盒，其具有小的占用空间并被配置为可移除地与系统接合。

公开(公告)号：EP3890886A1

公开(公告)日：2021-10-13

申请号：EP19828438.2

申请日：2019-12-04

申请人： IntegenX Inc.

发明人： VANGBO, Mattias ,  KING, David

IPC分类号： B01L3/00 ,  C12Q1/6858 ,  F16K7/00

公开(公告)号：EP3552690A1

公开(公告)日：2019-10-16

申请号：EP18248249.7

申请日：2015-10-21

申请人： IntegenX Inc.

发明人： KINDWALL, Alexander ,  PARK, Chungsoo, Charles ,  ILKOV, Fedor ,  JOVANOVICH, Stevan ,  KING, David ,  LITTLEHALE, Tristan, Robert ,  NILSON, David, Grant ,  PITTARO, Rick ,  SCHUEREN, Robert, A. ,  VANGBO, Mattias ,  WUNDERLE, Philip, Justus

IPC分类号： B01D59/42 ,  C25B11/02 ,  G01N27/447 ,  G01N27/49

摘要： The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system. An electrophoresis cartridge adapted to releasably engage with a cartridge interface of a system is provided. The electrophoresis cartridge (500) comprises: an electrophoresis assembly including: (1) an anode sub-assembly (507) comprising an anode (559), (2) a cathode sub-assembly (510) comprising a cathode (511); and (3) at least one electrophoresis capillary (509) having a first end and a second end, wherein the cathode (511) and the anode (529) are configured to provide a voltage gradient across the first end and the second end of the at least one electrophoresis capillary (509).

公开(公告)号：EP2606154A2

公开(公告)日：2013-06-26

申请号：EP11818879.6

申请日：2011-08-20

申请人： Integenx Inc.

发明人： JOVANOVICH, Stevan, B. ,  STERN, Seth ,  VAN GELDER, Ezra ,  VANGBO, Mattias

IPC分类号： C12Q1/70 ,  B01F3/00 ,  B01J19/00 ,  G01N1/00

CPC分类号： B01J19/0046 ,  B01J2219/00389 ,  B01J2219/00599 ,  B01J2219/00716 ,  B01J2219/00722 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0084

摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.

摘要翻译： 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，图书馆建设，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 综合分析可以在组织样本，临床样本或环境样本上进行。 集成分析系统可以在一个指定的时间内具有紧凑的格式并返回结果。

公开(公告)号：EP2438016A1

公开(公告)日：2012-04-11

申请号：EP10784213.0

申请日：2010-06-04

申请人： IntegenX Inc.

发明人： JOVANOVICH, Stevan, B. ,  NIELSEN, William, D. ,  COHEN, David, S. ,  RECKNOR, Michael ,  VANGBO, Mattias ,  VAN GELDER, Ezra ,  MAJLOF, Lars ,  EL-SISSI, Omar

IPC分类号： C02F1/40

CPC分类号： C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post- reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft
3 , and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.