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1.发明公开ANTI-FELINE HERPESVIRUS-1 RECOMBINANT ANTIBODY AND GENE FRAGMENT CODING FOR SAID ANTIBODY 失效重组抗体针对猫疱疹病毒-1基因片段和编码它们。
公开(公告)号：EP0671472A1
公开(公告)日：1995-09-13
申请号：EP94901002.9
申请日：1993-11-25
CPC分类号： C07K16/085 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S424/80 , Y10S424/801 , Y10S424/809
摘要： An anti-feline herpesvirus-1 recombinant antibody which is efficacious in treating, preventing and diagnosing feline herpesvirus-1 (FHV-1) infection, and a gene fragment useful for the preparation of the antibody. A gene fragment coding for the antibody V region bearing an FHV-1 specific avidity of a mouse monoclonal antibody having an excellent activity of neutralizing FHV-1 is obtained by constructing cells which produce the antibody. A chimeric anti-FHV-1 recombinant antibody is prepared from the above gene fragment and another gene fragment coding for a feline antibody C region.
摘要翻译： 抗猫疱疹病毒-1重组抗体的所有这是在治疗，预防和诊断猫疱疹病毒-1（FHV-1）感染是有效的，和对抗体的制备中有用的基因片段。 的基因片段编码用于在具有中和FHV-1是通过构造其中产生抗体的细胞获得的优异活性的小鼠单克隆抗体的FHV-1特异性亲合力的抗体V区的轴承。 嵌合的抗FHV-1重组抗体是由上述基因片段和猫科动物抗体C区的另一种基因片段编码制备。
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2.发明公开
公开(公告)号：EP2022849A1
公开(公告)日：2009-02-11
申请号：EP07743165.8
申请日：2007-05-11
CPC分类号： C12N7/00 , A61K2039/525 , C12N2501/70 , C12N2760/16051
摘要： A method for producing influenza virus on large scale is provided. A method for propagating influenza virus which comprises, after removing or decreasing a trypsin inhibitor secreted into culture of MDCK cells (cell line derived from dog kidney) by washing with a culture medium or a buffer, inoculating influenza virus into said cells and culturing said influenza virus-inoculated cells in a culture medium supplemented with trypsin.
摘要翻译： 提供了大规模生产流感病毒的方法。 一种传播流感病毒的方法，其特征在于，在通过用培养基或缓冲液洗涤除去或降低分泌到MDCK细胞（狗肾细胞系）的培养物中的胰蛋白酶抑制剂后，将流感病毒接种到所述细胞中并培养所述流感 病毒接种的细胞在补充有胰蛋白酶的培养基中。
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3.发明授权ANTI-FELINE HERPESVIRUS-1 RECOMBINANT ANTIBODY AND GENE FRAGMENT CODING FOR SAID ANTIBODY 失效重组抗体针对猫疱疹病毒-1和基因片段编码它们
公开(公告)号：EP0671472B1
公开(公告)日：2001-03-14
申请号：EP94901002.9
申请日：1993-11-25
CPC分类号： C07K16/085 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S424/80 , Y10S424/801 , Y10S424/809
摘要： An anti-feline herpesvirus-1 recombinant antibody which is efficacious in treating, preventing and diagnosing feline herpesvirus-1 (FHV-1) infection, and a gene fragment useful for the preparation of the antibody. A gene fragment coding for the antibody V region bearing an FHV-1 specific avidity of a mouse monoclonal antibody having an excellent activity of neutralizing FHV-1 is obtained by constructing cells which produce the antibody. A chimeric anti-FHV-1 recombinant antibody is prepared from the above gene fragment and another gene fragment coding for a feline antibody C region.
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公开(公告)号：EP0671471B1
公开(公告)日：1999-04-07
申请号：EP94901001.1
申请日：1993-11-25
CPC分类号： C12N15/85 , C07K16/00 , C12N2840/20 , C12N2840/44
摘要： A process for efficiently producing a foreign protein, in particular, a novel foreign protein suitable for the expression of a recombinant antibody with eucaryotic cells by the genetic recombination techniques, wherein a cell containing a foreign gene introduced thereinto can be cultured in a serum-free medium by using as a host cell for foreign gene expression a fused cell obtained by the fusion of mouse myeloma with a lymphoid cell and culturable in a serum-free medium.
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公开(公告)号：EP0671471A1
公开(公告)日：1995-09-13
申请号：EP94901001.1
申请日：1993-11-25
CPC分类号： C12N15/85 , C07K16/00 , C12N2840/20 , C12N2840/44
摘要： A process for efficiently producing a foreign protein, in particular, a novel foreign protein suitable for the expression of a recombinant antibody with eucaryotic cells by the genetic recombination techniques, wherein a cell containing a foreign gene introduced thereinto can be cultured in a serum-free medium by using as a host cell for foreign gene expression a fused cell obtained by the fusion of mouse myeloma with a lymphoid cell and culturable in a serum-free medium.
摘要翻译： 一种有效生产外源蛋白质的方法，特别是适用于通过遗传重组技术用真核细胞表达重组抗体的新颖外源蛋白质，其中含有外源基因的细胞可以在无血清培养 通过使用通过小鼠骨髓瘤与淋巴样细胞融合而获得的融合细胞作为外源基因表达的宿主细胞，并在无血清培养基中培养的培养基。
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