-
公开(公告)号：EP3981788A1
公开(公告)日：2022-04-13
申请号：EP20819147.8
申请日：2020-06-03
发明人： SHI, Jinping , YING, Hua , LI, Tingting , WANG, Yifang , YANG, Guimei , GE, Hu , TAO, Weikang
IPC分类号： C07K16/24 , C12N15/13 , A61K39/395
摘要： Disclosed are an antibody capable of binding to thymic stromal lymphopoietin and the use thereof. Disclosed are an anti-TSLP antibody, comprising a murine antibody, chimeric antibody and humanized antibody of the light chain and heavy chain variable regions of the anti-TSLP antibody and antigen-binding fragments thereof, or a pharmaceutically acceptable salt or solvent compound thereof, and the use thereof as a medicament for treating asthma, especially the use thereof in the preparation of a drug for treating TSLP-positive diseases or conditions.
-
公开(公告)号：EP3950716A1
公开(公告)日：2022-02-09
申请号：EP20782022.6
申请日：2020-03-31
发明人： YANG, Yang , GE, Hu , TAO, Weikang
IPC分类号： C07K16/30 , C12N15/13 , A61P35/00 , A61K39/395
摘要： The present disclosure relates to an anti-Claudin 18.2 antibody and an application thereof. Specifically, the present invention relates to an anti-Claudin 18.2 antibody; a mouse-derived antibody, chimeric antibody, humanized antibody and antigen-binding fragment thereof which contain a CDR of the anti-Claudin 18.2 antibody, and a use thereof as a medicine. In particular, the present disclosure relates to a use of the anti-Claudin 18.2 antibody in the preparation of a drug for treating Claudin 18.2 positive diseases or disorders.
-
公开(公告)号：EP3950693A1
公开(公告)日：2022-02-09
申请号：EP20779336.5
申请日：2020-03-27
发明人： LI, Xin , CHEN, Yang , FENG, Binqiang , HE, Feng , TAO, Weikang
IPC分类号： C07D495/04 , C07D498/08 , A61K31/5377 , A61K31/4439 , A61P35/00
摘要： Provided are a thienoheterocyclic derivative, a preparation method therefor and the medical use thereof. In particular, provided are a thienoheterocyclic derivative represented by formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, the use of same as a therapeutic agent, particularly as an ERK inhibitor, and the use of same in the preparation of a drug for treating or preventing cancers, inflammation or other proliferative diseases, wherein each substituent of formula (I) is the same as defined in the description.
-
4.发明公开
公开(公告)号：EP3950690A1
公开(公告)日：2022-02-09
申请号：EP20783525.7
申请日：2020-03-27
发明人： LI, Xin , CAI, Guodong , YANG, Fang , HE, Feng , TAO, Weikang
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/519 , A61P35/00 , A61P29/00
摘要： The present application provides a pyrroloheterocyclic derivative, a preparation method therefor, and an application thereof in medicine. Specifically, the present application provides a novel pyrroloheterocyclic derivative as represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and an application of the derivative as a therapeutic agent, particularly as an ERK inhibitor, wherein substituents in the formula have the same definitions as those in the description.
-
公开(公告)号：EP3943511A1
公开(公告)日：2022-01-26
申请号：EP20772799.1
申请日：2020-03-17
发明人： YING, Hua , SHI, Jinping , MAO, Langyong , GE, Hu , YANG, Xiaoying , TAO, Weikang
IPC分类号： C07K16/46 , C07K16/22 , C07K16/28 , C12N15/13 , C12N5/10 , A61K39/395 , A61P35/00 , A61P27/02
摘要： The present disclosure provides a bispecific antibody specifically bound to VEGF and ANG2, comprising an anti-VEGF antibody or antigen-binding fragment thereof that specifically binds to VEGF, and an anti-ANG2 single-domain antibody that specifically binds to ANG2, wherein the anti-ANG2 single domain antibody is directly or indirectly connected to the anti-VEGF antibody or an antigen-binding fragment thereof. The present disclosure further provides an anti-ANG2 single domain antibody and an antigen-binding fragment thereof, as well as a preparation and application of said antibody.
-
公开(公告)号：EP3813827A1
公开(公告)日：2021-05-05
申请号：EP19825637.2
申请日：2019-06-28
发明人： LIU, Dong , CHEN, Lei , ZHUANG, Linghang , LI, Puhui , ZHANG, Xinzhu , SONG, Chunying , MILLER, Matthew , HU, Qiyue , YAN, Yuna , HE, Feng , TAO, Weikang
IPC分类号： A61K31/4164 , C07D403/14
-
7.发明公开
公开(公告)号：EP3636646A1
公开(公告)日：2020-04-15
申请号：EP18803089.4
申请日：2018-05-17
发明人： ZHANG, Guobao , MA, Dianqiang , YUAN, Huiqing , HE, Feng , TAO, Weikang
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P31/22 , A61P31/14 , A61P31/20
摘要： The present invention relates to a heteroaryl-pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new heteroaryl-pyrazole derivative as shown in formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, and a use of the derivative as a therapeutic agent, in particular as a TLR7 agonist. The substituents in formula (I) have the same definitions as in the description.
-
公开(公告)号：EP3604337A1
公开(公告)日：2020-02-05
申请号：EP18776535.9
申请日：2018-03-30
发明人： GU, Jinming , WANG, Xiaohua , YE, Xin , YANG, Liuqing , ZHANG, Ting , TAO, Weikang , ZHANG, Lianshan
摘要： The invention provides a B7-H3 antibody, an antigen-binding fragment thereof and a medical use thereof. Furthermore, the present invention discloses a pharmaceutical composition comprising the B7-H3 antibody or antigen-binding fragment thereof, and the use thereof as a medicament. In particular, the invention discloses a use of a human B7-H3 antibody or antigen-binding fragment thereof for the manufacture of a medicament for the treatment of B7-H3-associated disease or condition.
-
9.发明公开
公开(公告)号：EP3560918A1
公开(公告)日：2019-10-30
申请号：EP17882608.7
申请日：2017-12-20
发明人： LI, Xin , HE, Wei , WANG, Bin , ZHANG, Zhigao , HE, Feng , TAO, Weikang
IPC分类号： C07D401/14 , A61K31/4196 , A61K31/397 , A61P15/00
摘要： The present invention relates to a condensed ring group azacyclobutyl triazole derivative, a preparation method therefor and use thereof in medicine. In particular, the present invention relates to a novel condensed ring group azacyclobutyl triazole derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, use thereof as a therapeutic agent, in particular as an oxytocin antagonist, and use thereof in the preparation of a medicament used for treating or preventing a disease or a condition that is known or can exhibit a beneficial effect of inhibiting oxytocin. The definition for each substituent in general formula (I) is the same as that in the description.
-
公开(公告)号：EP3081576B1
公开(公告)日：2019-08-21
申请号：EP14868918.5
申请日：2014-11-14
发明人： YUAN, Jijun , QU, Xiangdong , LIN, Jufang , YE, Xin , CAO, Guoqing , TAO, Weikang , ZHANG, Lianshan , ZHANG, Lei , YANG, Li
-
-
-
-
-
-
-
-
-
搜索结果
101 条记录 (耗时 0.027 秒)
