公开(公告)号：EP2524703A4

公开(公告)日：2014-03-12

申请号：EP10842991

申请日：2010-11-24

Applicant: KANEKA CORP

Inventor： YAMASHITA KENJI ,  YAGUCHI SHIGERU ,  MURATA SHOICHI

IPC: A61L9/01 ,  B01D39/14 ,  B01D39/16 ,  B01D39/18 ,  D04H1/407 ,  D04H1/64 ,  D06M15/15

CPC classification number: B01D39/1623 ,  B01D39/1615 ,  B01D2239/0442 ,  B01D2239/045 ,  B01D2239/0471 ,  B01D2239/064 ,  D04H1/407 ,  D06M11/45 ,  D06M11/46 ,  D06M11/47 ,  D06M11/48 ,  D06M15/15

公开(公告)号：EP0957160A4

公开(公告)日：2003-06-11

申请号：EP97937835

申请日：1997-08-29

Applicant: KANEKA CORP

Inventor： YAMASHITA KENJI ,  FUKUCHI TAKESHI ,  NISHINO TOMOKO

IPC: A61K35/12 ,  C12M3/00 ,  C12N5/0783 ,  C12N5/00 ,  C12M1/00 ,  C12M1/22 ,  C12M1/24 ,  C12N5/06

CPC classification number: C12N5/0636 ,  A61K2035/122 ,  C12M25/00 ,  C12N2501/23 ,  C12N2501/515 ,  C12N2501/599

Abstract: The present invention provides a method for inducing immunosuppressive cells by cultivating human cells with the use of a culture device having an affinity for protein and the culture device to be used therefor. According to the present invention, immunosuppressive cells can be efficiently induced by using a solid culture and can provide an efficient therapeutic system for diseases caused by hypersensitivity of the immune system with less side effect.

公开(公告)号：EP2397035A4

公开(公告)日：2012-09-12

申请号：EP09841507

申请日：2009-09-10

Applicant: KANEKA CORP ,  OSAKA MUNICIPAL TECH RES INST

Inventor： YAMASHITA KENJI ,  OMOTO TAKASHI ,  MORIYOSHI KUNIHIKO ,  KAWANO HIROAKI

IPC: A01N59/16 ,  A01N25/08 ,  A01N25/10 ,  A01N59/06 ,  A01N59/20 ,  A01P3/00

CPC classification number: A01N59/16 ,  A01N25/08 ,  A01N25/10 ,  A01N59/06 ,  A01N59/26 ,  A01N2300/00

Abstract: An antibacterial agent of the present invention contains a metal-containing compound containing a metal other than aluminum, and a phosphorus-adsorbing material. A method of using an antibacterial agent of the present invention is a method for improving an antibacterial property of a metal-containing compound containing a metal other than aluminum, wherein the metal-containing compound and a phosphorus-adsorbing compound are used in combination. Thus, the present invention provides an antibacterial agent, and a method of using an antibacterial agent, wherein an antibacterial property of a metal-containing compound containing a metal other than aluminum, particularly a silver-containing compound, is improved significantly.

公开(公告)号：EP2031011A4

公开(公告)日：2011-08-31

申请号：EP07744407

申请日：2007-05-30

Applicant: KANEKA CORP

Inventor： YAMASHITA KENJI

IPC: C08H1/06 ,  A01N59/06 ,  A01N61/00 ,  A01P3/00 ,  B01J20/26 ,  C08B11/12 ,  C08F8/44 ,  C08H99/00 ,  C08J3/12 ,  C08L1/26 ,  C08L29/04 ,  C08L89/04 ,  C08L101/00

CPC classification number: C08L75/00 ,  A01N59/06 ,  B01J20/0248 ,  B01J20/0281 ,  B01J20/0288 ,  B01J20/08 ,  B01J20/24 ,  B01J20/261 ,  B01J20/262 ,  B01J20/265 ,  B01J20/267 ,  C08F8/44 ,  C08H1/06 ,  C08J3/12 ,  C08J2329/04 ,  C08J2389/04 ,  C08K3/24 ,  C08K3/30 ,  C08K5/1515 ,  C08K7/20 ,  C08K9/08 ,  C08K2201/013 ,  C08L1/286 ,  C08L75/04 ,  C08L89/04 ,  C08L89/06 ,  Y10T428/2982 ,  A01N25/10 ,  A01N25/08 ,  A01N25/12 ,  A01N2300/00 ,  C08F16/06 ,  C08L2666/26

公开(公告)号：EP1388327A4

公开(公告)日：2009-08-19

申请号：EP02769619

申请日：2002-05-17

Applicant: KANEKA CORP ,  TABATA YASUHIKO ,  SAITO AKIHIKO

Inventor： TABATA YASUHIKO ,  SAITO AKIHIKO ,  GEJYO FUMITAKE ,  FURUYOSHI SHIGEO ,  YAMASHITA KENJI

IPC: A61F2/02 ,  A61K45/00 ,  A61L27/38 ,  A61L27/52 ,  A61P1/16 ,  C12N5/08

CPC classification number: A61L27/3813 ,  A61F2/02 ,  A61L27/3839 ,  A61L27/52 ,  A61L2430/26

Abstract: It is intended to provide an artificial kidney of intra-corporeal type which has a function of metabolizing protein. Namely, an artificial kidney of intra-corporeal type which has a function of metabolizing protein characterized by having as constituting members a sponge sheet having a hydrogel ontaining a growth factor, which promotes angiogenesis, injected thereinto and cells having megalin, which is an endocytosis receptor playing a major role in protein metabolism in proximal convoluted tubular cells, expressed on the surface; and a method of constructing an artificial kidney of intra-corporeal type which has a function of metabolizing protein characterized by using a sponge sheet having a hydrogen containing a growth factor, which promotes angiogenesis, injected thereinto and cells having megalin expressed on the surface.

公开(公告)号：EP1518929A4

公开(公告)日：2005-11-23

申请号：EP03744510

申请日：2003-03-06

Applicant: KANEKA CORP

Inventor： NIWA HIDEO ,  YAMASHITA KENJI

IPC: C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  C07K16/18 ,  C12N5/10

CPC classification number: C12Q1/6883 ,  C07K14/47

Abstract: It is intended to detect and screen proliferative insulin-producing cells and to differentiate and proliferate the insulin-producing cells, precursor cells thereof or cells analogous thereto. Genes expressed specifically in the pancreas of a PHHI patient, which are seemingly spontaneous proliferation models of pancreatic beta cells, are detected and, by searching for on a base sequence database, three novel genes are found out. Using these genes, gene products thereof or gene sequences thereof, insulin-producing cells under proliferation can be detected by, for example, Northern analysis or RT-PCR. By transferring these genes into appropriate cells by genetic engineering techniques, moreover, these cells can be differentiated into insulin-producing cells.

公开(公告)号：EP1541182A4

公开(公告)日：2010-11-17

申请号：EP03808880

申请日：2003-09-09

Applicant: KANEKA CORP ,  G C DENTAL IND CORP ,  NAT INST OF ADVANCED IND SCIEN

Inventor： NIWA HIDEO ,  FUKUCHI TAKESHI ,  SHIMIZU ICHIRO ,  SATO MASAO ,  NISHI AKIKO ,  YAMASHITA KENJI ,  KANEKO TADASHI ,  OHGUSHI HAJIME ,  HATTORI KOJI ,  UEMATSU KOTA

IPC: C12M3/00 ,  A61L27/00 ,  A61L27/38 ,  A61L27/56 ,  C12N5/00 ,  C12N5/077 ,  C12N5/08

CPC classification number: A61L27/3895 ,  A61L27/3852 ,  A61L27/56 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/40

公开(公告)号：EP1669453A4

公开(公告)日：2007-12-12

申请号：EP04787861

申请日：2004-09-10

Applicant: KANEKA CORP ,  FOUND BIOMEDICAL RES & INNOV

Inventor： SYOFUDA TOMOKO ,  KANEMURA YONEHIRO ,  MIYAKE JUN ,  NIWA HIDEO ,  YAMASHITA KENJI

IPC: C12N15/12 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566

CPC classification number: G01N33/5058 ,  C12Q1/6876 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5073 ,  G01N2500/00

Abstract: It is intended to provide a method of detecting a nerve stem cell/a precursor cell from a tissue or a mass of cells composed of cells of a plurality of types, and a method of screening a drug capable of serving as a nerve differentiation factor, etc. by using the detection method. It is found out that NC1 gene shows a high expression level in undifferentiated nerve stem cells and its expression level is lowered as the differentiation proceeds. Thus, a nerve stem cell/a precursor cell can be detected by various methods with the use of the NC1 gene, its gene product (NC1 protein), a base sequence or an amino acid sequence originating therein, an antibody and so on, and a novel method for screening a drug capable of serving as a nerve differentiation factor can be provided.