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    Quinazoline derivatives as kinase inhibitors
    2.
    发明公开
    Quinazoline derivatives as kinase inhibitors 审中-公开
    Quinazolinderivate als Kinasehemmer

    公开(公告)号：EP2277877A1

    公开(公告)日：2011-01-26

    申请号：EP10182322.7

    申请日：2001-08-17

    申请人： MILLENNIUM PHARMACEUTICALS, INC. ,  Kyowa Hakko Kogyo Co., Ltd

    发明人： Pandey, Anjali ,  Scarborough, Carroll ,  Matsuno, Kenji ,  Ichimura, Michio ,  Nomoto, Yuji ,  Ide, Schinichi ,  Tsukuda, Eiji ,  Irie, Junko ,  Oda, Shoji

    IPC分类号： C07D403/12 ,  C07D239/94 ,  C07D401/12 ,  A61P35/00 ,  A61K31/517

    CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinase and treating disese states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制激素和治疗哺乳动物中的二恶烷状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化，血管 重建，癌症和肾小球硬化。

    Quinazoline derivatives as kinase inhibitors
    4.
    发明公开
    Quinazoline derivatives as kinase inhibitors 审中-公开
    喹唑啉衍生物作为激酶抑制剂

    公开(公告)号：EP1964839A2

    公开(公告)日：2008-09-03

    申请号：EP08075237.1

    申请日：2001-08-17

    申请人： MILLENNIUM PHARMACEUTICALS, INC. ,  KYOWA HAKKO KOGYO CO., LTD.

    发明人： Pandey, Anjali ,  Scarborough, Robert, M. ,  Matsuno, Kenji ,  Ichimura, Michio ,  Nomoto, Yuji ,  Ide, Shinichi ,  Tsukuda, Eiji ,  Irie, Junko ,  Oda, Shoji

    IPC分类号： C07D403/12 ,  C07D239/94 ,  C07D401/12 ,  A61P35/00 ,  A61K31/517

    CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

    摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

    摘要翻译： 本发明涉及对激酶的磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐，其抑制这些激酶的活性。 本发明还涉及抑制激酶并通过抑制激酶的磷酸化来治疗哺乳动物的疾病状态的方法。 本发明的一个特定方面提供了抑制PDGF受体的磷酸化以阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管性 重建，癌症和肾小球硬化。