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    POLYETHYLENE OXIDES HAVING SACCHARIDE RESIDUE AT ONE END AND DIFFERENT FUNCTIONAL GROUP AT ANOTHER END, AND PROCESS FOR PRODUCING THE SAME
    6.
    发明公开
    POLYETHYLENE OXIDES HAVING SACCHARIDE RESIDUE AT ONE END AND DIFFERENT FUNCTIONAL GROUP AT ANOTHER END, AND PROCESS FOR PRODUCING THE SAME 失效
    与糖类结束了，其它官能团的另一端及其制造方法聚氧化乙烯

    公开(公告)号：EP0852243A1

    公开(公告)日：1998-07-08

    申请号：EP96909364.0

    申请日：1996-04-12

    申请人： Kataoka, Kazunori

    发明人： KATAOKA, Kazunori ,  NAGASAKI, Yukio ,  KATO, Masao ,  OKANO, Teruo ,  NAKAMURA, Teruo

    IPC分类号： C08G65/32

    CPC分类号： C08L71/02 ,  A61K47/60 ,  A61K47/6907 ,  C08G63/664 ,  C08G65/2606 ,  C08G65/329 ,  Y10T428/2984 ,  Y10T428/2985 ,  C08L2666/18

    摘要： This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula:
    wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula
    or (̵CH 2 )̵ 4

    wherein R 1 and R 2 independently denote lower alkyl, aralkyl or aryl,
    X denotes a single bond or -CH 2 CH 2 -, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to -CH 2 CH 2 -, n denotes an integer of 5 - 10,000, and m denotes an integer of 0 or 2 - 10,000.

    This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.

    摘要翻译： 本发明提供了由下式表示的杂远螯低聚物或聚合物全部 worin A表示的糖残基，L表示由下式表示的键合基团或＆lparstr＆CH2 .paren靠近-ST＆4 worin - [R <1>和 [R <2>独立地表示低级烷基，芳烷基或芳基，X表示单键或-CH 2 CH 2，Z表示基团在不饱和酯或醚，或官能团形成：如卤素，其结合-CH2CH2 - ，n表示 到10.000的5整数，m表示在10.000的0或2的整数。 所以本发明提供了一种生产上述低聚物或聚合物，并且进一步高分子胶束与使用具有在其末端的糖残基的聚环氧乙烷 - 聚酯嵌段聚合物。 所述低聚物或聚合物，预计表现出优异的生物利用度，并且因此预计在该领域被利用：例如用于药物递送或诊断试剂的载体。

    HETEROTELECHELIC BLOCK COPOLYMERS AND PROCESS FOR PRODUCING THE SAME
    7.
    发明公开
    HETEROTELECHELIC BLOCK COPOLYMERS AND PROCESS FOR PRODUCING THE SAME 失效
    VERFAHREN ZU DEREN HERSTELLUNG的HETEROTELECHELISCHE BLOCKCOPOLYMERE

    公开(公告)号：EP0822217A1

    公开(公告)日：1998-02-04

    申请号：EP96910195.5

    申请日：1996-04-18

    申请人： Kataoka, Kazunori

    发明人： KATAOKA, Kazunori ,  SCHOLZ, Carmen ,  IIJIMA, Michihiro ,  KUTSUNA, Takahiko ,  NAGASAKI, Yukio ,  KATO, Masao ,  OKANO, Teruo

    IPC分类号： C08G65/26 ,  C08G65/32 ,  C08G63/66 ,  C08G63/08

    CPC分类号： A61K9/1075 ,  A61K47/60 ,  C08G63/664 ,  C08G65/2609 ,  C08G65/3324 ,  C08L71/02 ,  Y10S525/922 ,  C08L2666/18

    摘要： This invention provides a heterotelechelic oligomer or polymer which is represented by formula below:


    wherein R 1 and R 2 form an acetal, or, combined with each other, denote oxy (= O),

    p, m, n and q each denote a certain integer,
    L is a group which forms an ester, and
    Z denotes a certain functional group.


    This invention also provides a process to produce the above oligomer or polymer by means of living polymeri-zation. Since this oligomer or polymer forms a high- molecular micelle which is stable in an aqueous solvent, said oligomer or polymer will be useful as a carrier for drug delivery.

    摘要翻译： 本发明提供了由下式表示的杂多炔类低聚物或聚合物：其中R 1和R 2形成缩醛，或彼此组合表示氧（= O），p，m， n和q各自表示一个整数，L是形成酯的基团，Z表示某一官能团。 本发明还提供了通过活性聚合制备上述低聚物或聚合物的方法。 由于该低聚物或聚合物形成在水性溶剂中稳定的高分子胶束，因此所述低聚物或聚合物可用作药物递送载体。

    BLOCK POLYMER HAVING FUNCTIONAL GROUPS AT BOTH ENDS
    9.
    发明公开
    BLOCK POLYMER HAVING FUNCTIONAL GROUPS AT BOTH ENDS 失效
    BLOCKPOLYMERE MIT FUNKELLELLEN GRUPPEN BE BEENEN KETTENENDEN

    公开(公告)号：EP0844269A1

    公开(公告)日：1998-05-27

    申请号：EP96925998.5

    申请日：1996-08-05

    申请人： Kataoka, Kazunori

    发明人： KATAOKA, Kazunori ,  KATO, Masao ,  NAGASAKI, Yukio ,  OKANO, Teruo

    IPC分类号： C08G85/00 ,  C08F297/00 ,  C08G63/66 ,  C08G63/91 ,  C08G65/32 ,  A61K47/48

    CPC分类号： A61K9/1075 ,  A61K9/5153 ,  C08G63/664 ,  C08G63/676 ,  C08G63/912 ,  C08G65/2627 ,  C08G65/329 ,  C08G85/00 ,  C08L71/02 ,  C08L2666/18

    摘要： The present invention provides a block polymer which has functional groups on its both ends, and which comprises hydrophilic/hydrophobic segments. As for the functional groups on its both ends, the block polymer has amino group, carboxyl group or mercapto group on α-terminal, and hydroxyl group, carboxyl group, aldehyde group or vinyl group on ω-terminal. Hydrophilic segment comprises polyethylene oxide, while hydrophobic segment is derived from lactide, lactone or (meth)acrylic acid ester. The block polymer of this invention forms a polymeric micelle which is usable as bio-compatible materials.

    摘要翻译： 本发明提供了在其两端具有官能团并且包含亲水/疏水链段的嵌段聚合物。 对于其两端的官能团，嵌段聚合物在α-末端具有氨基，羧基或巯基，在ω-末端具有羟基，羧基，醛基或乙烯基。 亲水链段包括聚环氧乙烷，而疏水链段来自丙交酯，内酯或（甲基）丙烯酸酯。 本发明的嵌段聚合物形成可用作生物相容性材料的聚合胶束。