摘要:
The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such protein. To achieve this object, a protein is used, as novel protein having adiponectin binding ability, that is (a) a protein comprising an amino acid sequence according to Seq. No. 2, 4, 6 or 8, or (b) a protein comprising an amino acid sequence according to Seq. No. 2, 4, 6 or 8 with one or more amino acids deleted, replaced or added, and having adiponectin binding ability.
摘要:
A projection image data captured from a plurality of angles is processed, and a three-dimensional image data accurately indicating a three dimensional structure for an object is obtained. A shape computing unit 260 computes shape data indicating an outline of a subject using a plurality of first image data of the subject captured from a plurality of angles. A distributing unit 220 generates a gray-scale density-distribution by extending and distributing density indicated in a gray-scale image of the subject acquired by a projection image capturing apparatus to an angle at which the gray-scale image is captured. The second integrating unit 240 generates a three-dimensional gray-scale data indicating the subject with three-dimensional image data by integrating a plurality of gray-scale images acquired from a plurality of angles and a plurality of gray-scale density-distribution. The first integrating unit 280 integrates the three-dimensional gray-scale image and shape data. The data processing unit 300 generates the three-dimensional image data by extracting only the gray-scale data which exists in the circumference of the shape indicated in the shape data from the three-dimensional gray-scale data.
摘要:
It is an object of the present invention to acquire 3-dimensional image data that correctly express a structural configuration of the subject by processing the projected image data obtained by projecting the subject toward the plural angles. A shape computing unit 260 calculates shape data which represent a outline of the subject, using a plurality of 1st image data of the subject obtained by projecting the subject toward the plural angles. A distributing unit 220 generates gray-scale density-distributions by spreading and distributing densities shown in gray-scale image of the subject respectively within angles along which said gray-scale image was captured. A second integrating unit 240 generates 3-dimensional gray-scale data which express the subject with the 3-dimensional image data, by integrating a plurality of said gray-scale density-distributions generated from a plurality of gray-scale image captured from a plurality of angles. A first integrating unit 280 integrates the shape data and 3-dimensional gray-scale image. A data processing unit 300 generates 3-dimensional image data by extracting only density that exists in perimeter of a shape that the shape data represent, from the 3-dimensional gray-scale data.
摘要:
The object of the present invention is to provide a technique for efficiently extracting GPCR sequences from human genome sequences, thereby comprehensively identifying novel GPCRs. An original automatic system for identifying GPCR sequences is disclosed, and 1035 novel GPCRs are successfully identified from the entire human genome by utilizing the system.
摘要:
A method for immobilizing substances by formation of plasma-polymerized films, after the arrangement of the substances to be immobilized on the surface of a support, and the immobilized substances according to the method are provided. The immobilized substances are retained with use of plasma-polymerized films, thereby damage to the immobilized substances is minimized, and the liberation of the substances after the immobilization will hardly occur. They can be further applied for indirect immobilization of biotinylated polynucleotides, because binding activities of the substances are kept on the surface. In addition, proteins having binding activities such as antibodies can be immobilized to be used for the detection of ligands.
摘要:
A cleaning method for removing deposition such as scale adhering to the surface of a structure and a structure using this are disclosed. A surface layer that contains a radiocatalyst 5 is provided on the surface of a structure 1. A contaminating substance adhered on said surface layer is decomposed, and/or adhesion of a contaminating substance onto said surface layer is inhibited by irradiating said surface with radiation. A structure corrosion prevention method is also disclosed. A surface layer that contains a radiocatalyst is provided on the surface of a structure, the corrosion potential of said surface being decreased by irradiating said surface with radiation.
摘要:
The invention relates to a radiation detector. The detector includes an insulating substrate, a thin-film layer made of semiconductor or insulator formed on the surface of the substrate, at least a pair of electrodes provided on the thin-film layer, voltage applying means for applying a voltage across the electrodes and current detection means for detecting current taken from the electrodes, wherein radiation is detected using the fact that conductance of the thin-film layer changes linearly with respect to radiation intensity due to irradiation with radiation. Preferably, the thin-film layer comprises a metallic oxide. The metallic oxide comprises either one or any combination of two or more selected from titanium oxide, aluminum oxide (alumina), zirconium oxide, iron oxide, zinc oxide, yttrium oxide, manganese oxide, neodymium oxide, ceric oxide, tin oxide, or strontium titanate.
摘要:
Provided is a complex comprising cisplatin encapsulated therein in a form in which a chlorine ion thereof is ligand-exchanged with a carboxyl anion of a block copolymer comprising poly(ethylene glycol)-poly(glutamic acid). This complex can be a medicinal preparation to which a novel dosage form decreased in toxicity can be applied.
摘要:
The present invention provides a method for screening substances which specifically inhibit the non-mevalonate pathway by using an organism capable of using both the mevalonate pathway and the non-mevalonate pathway as biosynthetic pathways of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). According to the present invention, it is possible to provide a novel method for screening anti-bacterial agents, herbicides or anti-malarial agents which can specifically inhibit any of the enzyme reactions on the non-mevalonate pathway for the synthesis of isopentenyl diphosphate and dimethylallyl diphosphate (DMAPP).
摘要:
Provided are a dispersion comprising organic-inorganic hybrid type particles carried thereon with a biologically active substance, wherein the above particles can be obtained by allowing a block copolymer represented by Formula (I):
PEG-block-poly(carbo) (I)
(wherein PEG represents a polyethylene glycol segment, and carbo represents a repetitive unit having a carboxylate ion on a side chain) and an aqueous medium system capable of forming hydroxyapatite to coexist with the biologically active substance, and a preparing method for the same.