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    DISCRIMINATION METHOD FOR MUTATION-INDUCED UNICELLULAR ORGANISM AND MICROFLUIDIC DEVICE USED THEREFOR
    4.
    发明公开
    DISCRIMINATION METHOD FOR MUTATION-INDUCED UNICELLULAR ORGANISM AND MICROFLUIDIC DEVICE USED THEREFOR 有权
    伊斯兰威尔经济社会组织有限责任公司VORRICHTUNGDAFÜR

    公开(公告)号：EP2947154A1

    公开(公告)日：2015-11-25

    申请号：EP14740606.0

    申请日：2014-01-14

    申请人： Korea University Research and Business Foundation

    发明人： SIM, Sang Jun ,  KIM, Young Hwan ,  KWAK, Ho Seok

    IPC分类号： C12Q1/04 ,  G01N35/08 ,  G01N21/76

    CPC分类号： C12Q1/02 ,  B01L3/5027 ,  C12Q1/04 ,  G01N2035/00158

    摘要： The present invention discloses a microfluidic photoreaction system and a method for screening a single cell organism having changed light-response characteristics. According to the present invention, an improved single cell organism can be effectively screened based on phototaxis using a microfluidic system. Specifically, easy monitoring at the cellular level is possible, and a mutant strain having an increased response and/or sensitivity to light can be easily and rapidly screened by various analyses, including statistical analysis of collected results. Thus, the present invention can be effectively used to investigate the correlation between phototaxis and photoconversion efficiency and to screen a single cell organism having increased photosynthetic efficiency.

    摘要翻译： 本发明公开了微流体光反应系统和筛选具有改变的光响应特性的单细胞生物体的方法。 根据本发明，可以使用微流体系统基于光趋向性有效地筛选改进的单细胞生物体。 具体来说，在细胞水平上的容易监测是可能的，并且可以通过各种分析（包括收集结果的统计分析）容易且快速地筛选具有增加的对光的响应和/或敏感性的突变株。 因此，本发明可以有效地用于研究光趋向性和光转换效率之间的相关性，并筛选具有增加的光合效率的单细胞生物体。

    PH SENSITIVE FLUORESCENT POLYDIACETYLENE LIPOSOME AND DRUG DELIVERY VEHICLE COMPRISING SAME
    6.
    发明公开
    PH SENSITIVE FLUORESCENT POLYDIACETYLENE LIPOSOME AND DRUG DELIVERY VEHICLE COMPRISING SAME 有权
    PH-EMPFINDLICHES FLUORESZIERENDES POLYDIACETYLEN-LIPOSOM UNDARZNEIMITTELABGABETRÄGERSTOFFDAMIT

    公开(公告)号：EP2870959A1

    公开(公告)日：2015-05-13

    申请号：EP13812895.4

    申请日：2013-07-02

    申请人： Korea University Research and Business Foundation

    发明人： SIM, Sang Jun ,  WON, Sang Ho ,  LEE, Jong Uk

    IPC分类号： A61K9/127 ,  A61K47/48 ,  A61K47/30

    CPC分类号： A61K49/0084 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/43 ,  A61K47/12 ,  A61K47/183 ,  A61K47/24 ,  A61K49/0019

    摘要： The present invention relates to a drug delivery vehicle comprising a polydiacetylene liposome, wherein a lipid bilayer is formed by a mixture of 10,12-pentacosadiynoic acid (PCDA), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and N-palmitoyl homocysteine (PHC), and a drug to be delivered is encapsulated in an isolated inner space of a polydiacetylene liposome. The PDA liposome drug delivery vehicle of the present invention comprises a lipid layer formed by mixing different phospholipids, excluding polydiacetylene, so as to be stable, and thus any leakage problems of an encapsulated drug are eliminated. In addition, since the liposome is sensitive to a pH, the shape and size thereof can be readily changed through the formation of a liposome-liposome conjugate by the improved sensitivity of the drug delivery vehicle under a specific acidic requirement, thereby enabling selective drug release, and thus can be applied as a drug delivery vehicle for various target materials. Additionally, the release of a drug can be controlled by controlling a pH requirement of the surroundings, and a drug release process can be monitored in real time through the fluorescence expressed by the stimulation to the surroundings.

    摘要翻译： 本发明涉及包含聚二乙炔脂质体的药物递送载体，其中脂质双层由10,12-二十五二炔酸（PCDA），1,2-二油酰-sn-甘油-3-磷酸乙醇胺（DOPE）的混合物形成， 和N-棕榈酰高半胱氨酸（PHC），并且待递送的药物被包封在聚二乙炔脂质体的分离的内部空间中。 本发明的PDA脂质体药物输送载体包含通过混合除了聚二乙炔之外的不同磷脂形成的脂质层，以便稳定，从而消除了包封药物的任何泄漏问题。 此外，由于脂质体对pH敏感，因此通过在特定的酸性要求下药物递送载体的改善的敏感性，通过脂质体 - 脂质体缀合物的形成容易地改变其形状和大小，从而使选择性药物释放 ，因此可以用作各种靶材的药物输送载体。 另外，可以通过控制周围环境的pH要求来控制药物的释放，并且可以通过对周围环境的刺激表达的荧光来实时监测药物释放过程。

    METHOD FOR MICROALGAL CULTIVATION
    7.
    发明公开
    METHOD FOR MICROALGAL CULTIVATION 审中-公开

    公开(公告)号：EP4047080A1

    公开(公告)日：2022-08-24

    申请号：EP22157310.8

    申请日：2022-02-17

    申请人： Korea University Research and Business Foundation

    发明人： SIM, Sang Jun ,  JOUN, Jae Min ,  HONG, Min Eui

    IPC分类号： C12N1/12

    摘要： Disclosed is a method for microalgal cultivation. The method includes cultivating a microalgal species in a medium in an autotrophic mode for a predetermined first time period where light is supplied and supplying an organic carbon source to the medium to cultivate the microalgal species in a heterotrophic mode for a predetermined second time period where the supply of light is stopped.

    METHOD FOR PREPARING METAL NANOSTRUCTURE BASED ON BIOMOLECULES
    10.
    发明公开
    METHOD FOR PREPARING METAL NANOSTRUCTURE BASED ON BIOMOLECULES 审中-公开
    一种用于生产金属纳米结构的综合生物分子

    公开(公告)号：EP3034462A1

    公开(公告)日：2016-06-22

    申请号：EP14836685.9

    申请日：2014-07-03

    申请人： Korea University Research and Business Foundation

    发明人： SIM, Sang Jun ,  MA, Xingyi ,  LEE, Jong-Uk

    IPC分类号： B82B3/00 ,  B82B1/00

    摘要： The present invention relates to a method for preparing a metal nanostructure using a DNA and, more specifically, to a method for preparing a metal nanostructure, which easily controls the orientation, form and size compared to a conventional bottom-up method due to using a DNA having a self-assembling property as a frame. The metal nanostructure prepared by the method exhibits an excellent localized surface plasmon resonance phenomenon, and thus can be used as a fluorescent material in drug delivery, biomedical imaging, supersensitive biosensors, etc.