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    PYRAZOLOPYRIDINE DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF
    2.
    发明公开
    PYRAZOLOPYRIDINE DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF 审中-公开
    吡唑并吡啶衍生物

    公开(公告)号：EP2669285A1

    公开(公告)日：2013-12-04

    申请号：EP12739093.8

    申请日：2012-01-25

    申请人： Kyorin Pharmaceutical Co., Ltd. ,  Kissei Pharmaceutical Co., Ltd.

    发明人： SETO, Shigeki ,  UMEI, Kentaro ,  NISHIGAYA, Yosuke ,  TANIOKA, Asao ,  KONDO, Tatsuhiro ,  KONDO, Atsushi ,  TATANI, Kazuya ,  KAWAMURA, Naohiro

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  A61P13/02 ,  A61P43/00

    CPC分类号： C07D471/04

    摘要： A pyrazolopyridine derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof exhibits a strong EP 1 receptor antagonistic effect. Thus, the derivative or the pharmacologically acceptable salt is useful as a therapeutic agent for lower urinary tract symptoms (LUTS), particularly, overactive bladder syndrome (OABs), or a prophylactic agent therefor and furthermore, is also useful in the treatment, prevention, or suppression of various pathological conditions in which the EP 1 receptor is involved, such as inflammatory disease, pain disease, osteoporosis, and cancer.

    [A is a benzene ring or the like, Y 1 is C 1-6 alkylene, R 1 is -C(=O)-OZ 1 or the like, Z 1 is H or the like, R 2 is a branched C 3-6 alkyl group or the like, R 3 is H or the like, R 4 is a hydrogen atom or the like, and R 5 is a hydrogen atom or the like].

    摘要翻译： 由下式（I）表示的吡唑并吡啶衍生物或其药理学上可接受的盐表现出强烈的EP 1受体拮抗作用。 因此，衍生物或药理学上可接受的盐可用作下尿路症状（LUTS），特别是膀胱过度活动症（OAB）或其预防剂的治疗剂，此外，还可用于治疗，预防， 或抑制涉及EP 1受体的各种病理状况，例如炎性疾病，疼痛疾病，骨质疏松症和癌症。 [A是苯环等，Y 1是C 1-6亚烷基，R 1是-C（= O）-OZ 1等，Z 1是H等，R 2是支链C 3 -6烷基等，R 3为H等，R 4为氢原子等，R 5为氢原子等）。