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公开(公告)号：EP2796559A1
公开(公告)日：2014-10-29
申请号：EP14167362.4
申请日：2009-10-07
申请人： LS9, Inc.
发明人： HU, Zhihao , ARLAGADDA, Vikranth
IPC分类号： C12P7/04
CPC分类号： C12P7/64 , A61K31/045 , C12N1/20 , C12N9/0004 , C12N2501/71 , C12N2502/99 , C12P7/04 , C12R1/01 , Y02A50/473
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
摘要翻译： 方法和组合物，包括核苷酸序列，氨基酸序列和宿主细胞用于生产脂肪醇中描述。
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公开(公告)号：EP2352824A2
公开(公告)日：2011-08-10
申请号：EP09819847.6
申请日：2009-10-07
申请人： Ls9, Inc.
发明人： ALIBHAI, Murtaza, F. , HU, Zhihao
CPC分类号： C12N9/16 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/90 , C12N9/93 , C12N15/52 , C12P7/24 , Y02P30/10
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty aldehydes are described.
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3.发明公开PRODUCTION OF ODD CHAIN FATTY ACID DERIVATIVES IN RECOMBINANT MICROBIAL CELLS 审中-公开HERSTELLUNG VONFETTSÄUREDERIVATENMIT UNGERADEN KETTEN IN REKOMBINANTEN MIKROBIELLEN ZELLEN
公开(公告)号：EP2756090A1
公开(公告)日：2014-07-23
申请号：EP12709480.3
申请日：2012-03-08
申请人： LS9, Inc.
CPC分类号： C12P7/6409 , C07C53/126 , C07C57/03 , C12N9/0006 , C12N9/1018 , C12N9/1029 , C12N9/1217 , C12N9/16 , C12N9/18 , C12N9/88 , C12N9/90 , C12Y101/01003 , C12Y101/01085 , C12Y201/03001 , C12Y203/01041 , C12Y207/02004 , C12Y301/02001 , C12Y401/01041 , C12Y401/03022 , C12Y402/01033 , C12Y402/03001 , C12Y403/01019 , C12Y504/99002
摘要： Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
摘要翻译： 提供了重组微生物细胞，其已被工程化以通过脂肪酸生物合成途径产生具有含有奇数个碳原子的直链的脂肪酸衍生物。 还提供了使用重组微生物细胞制备奇数链脂肪酸衍生物的方法，以及包含通过这些方法产生的奇数链脂肪酸衍生物的组合物。
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公开(公告)号：EP2367947B1
公开(公告)日：2014-07-16
申请号：EP09829536.3
申请日：2009-10-07
申请人： LS9, Inc.
发明人： HU, Zhihao
IPC分类号： C12P7/04
CPC分类号： C12P7/64 , A61K31/045 , C12N1/20 , C12N9/0004 , C12N2501/71 , C12N2502/99 , C12P7/04 , C12R1/01 , Y02A50/473
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
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5.发明公开PRODUCTION OF BRANCHED CHAIN FATTY ACIDS AND DERIVATIVES THEREOF IN RECOMBINANT MICROBIAL CELLS 审中-公开脂肪酸与支链及其衍生物的重组微生物细胞产生
公开(公告)号：EP2663636A1
公开(公告)日：2013-11-20
申请号：EP11722657.1
申请日：2011-05-10
申请人： Ls9, Inc.
发明人： HU, Zhihao , LEE, Grace, J. , SCHIRMER, Andreas , ZAKHARYEVICH, Kseniya , GREENFIELD, Derek, L. , BARON, Tarah, S. , HOLDEN, Kevin
CPC分类号： C12N9/1029 , C12N9/0008 , C12N15/52 , C12P7/64
摘要： Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.
摘要翻译： 重组微生物的细胞提供已工程化以产生支链产品：如由脂肪酸生物合成途径分支的脂肪酸衍生物，以及制备使用所述重组微生物细胞支链脂肪酸衍生物的方法。
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公开(公告)号：EP2024491A2
公开(公告)日：2009-02-18
申请号：EP07809099.0
申请日：2007-05-18
申请人： Ls9, Inc.
发明人： KEASLING, Jay, D. , HU, Zhihao , SOMERVILLE, Chris , CHURCH, George , BERRY, David , FRIEDMAN, Lisa , SCHIRMER, Andreas , BRUBAKER, Shane , DEL CARDAYRÉ, Stephen, B.
摘要： Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.
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7.发明公开METHODS AND COMPOSITIONS FOR IMPROVED PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF 审中-公开方法和成分脂肪酸及其衍生物提高了生产
公开(公告)号：EP2906587A1
公开(公告)日：2015-08-19
申请号：EP12719914.9
申请日：2012-04-02
申请人： LS9, Inc.
发明人： GREENFIELD, Derek L. , HOM, Louis G. , SANCHEZ-RIERA, Fernando A. , HU, Zhihao , ARLAGADDA, Vikranth , GROBAN, Eli S. , FRYKMAN, Scott A.
IPC分类号： C07K14/195 , C07K14/245 , C12P5/00 , C12P7/64
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
摘要翻译： 本发明涉及组合物和方法，包括多核苷酸序列，氨基酸序列，和改造的宿主细胞用于生产脂肪酸和脂肪酸的衍生物：如酰基-CoA，末端烯烃，脂肪醛，脂肪醇，烷烃，烯烃蜡，酯 ，酮和通过转录因子，FADR的改变的表达的内烯烃。
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公开(公告)号：EP2024491B1
公开(公告)日：2014-11-19
申请号：EP07809099.0
申请日：2007-05-18
申请人： LS9, Inc.
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9.发明公开PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF HAVING IMPROVED ALIPHATIC CHAIN LENGTH AND SATURATION CHARACTERISTICS 审中-公开脂肪酸的生产和它们的衍生物具有改进的脂肪族链长度和饱和特性
公开(公告)号：EP2739726A1
公开(公告)日：2014-06-11
申请号：EP12745953.5
申请日：2012-08-17
申请人： LS9, Inc.
CPC分类号： C12N15/70 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/04 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/01042 , C12Y203/01041 , C12Y203/01179 , C12Y301/01005 , C12Y402/01059 , C12Y602/01003 , Y02E50/13
摘要： The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions. The compositions and methods provide for high titers, high yields, and high productivities of fatty acids and derivatives thereof.
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公开(公告)号：EP2367947A2
公开(公告)日：2011-09-28
申请号：EP09829536.3
申请日：2009-10-07
申请人： LS9, Inc.
发明人： HU, Zhihao
CPC分类号： C12P7/64 , A61K31/045 , C12N1/20 , C12N9/0004 , C12N2501/71 , C12N2502/99 , C12P7/04 , C12R1/01 , Y02A50/473
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
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