公开(公告)号：EP1432640A4

公开(公告)日：2005-05-04

申请号：EP02763452

申请日：2002-08-27

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  HANDLEY RICHARD S ,  SANDISON MARK D ,  LARKIN RANDALL K

IPC分类号： C09K3/00 ,  B01J31/02 ,  B01J31/06 ,  B01J35/00 ,  C08F8/00 ,  C08F8/44 ,  C08C19/22

CPC分类号： C08F8/44 ,  B01J31/0234 ,  B01J31/06 ,  B01J35/004 ,  C08F8/18 ,  C08F8/40 ,  C08F212/08

摘要： Improved polymer-immobilized photosensitizer are disclosed as well as methods of preparing and using them. The polymer-immobilized photosensitizers comprise a cross-linked polymer backbone, a plurality of cationic ammonium or phosphonium groups covalently bound to the polymer backbone and an immobilized photosensitizer. The average total number of carbon atoms in the ammonium or phosphonium group is at least four and preferably at least 12. The photosensitizer can be either covalently or ionically bound to the polymer. Polymer-supported photosensitizers of the invention are unexpectedly superior in catalyzing the photosensitized oxidation of compounds containing carbon-carbon double bonds.

公开(公告)号：EP1989332A4

公开(公告)日：2010-03-17

申请号：EP07757082

申请日：2007-02-16

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  DE SILVA RENUKA ,  EICKHOLT ROBERT A ,  MAZELIS MICHAEL E ,  XIE WENHUA ,  HANDLEY RICHARD S ,  BRAY MONICA A ,  MASTRONARDI MICHELLE L ,  O'CONNOR ELIZABETH A ,  SIRIPURAPU SARADA

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6806

公开(公告)号：EP1594855A4

公开(公告)日：2008-04-16

申请号：EP04711799

申请日：2004-02-17

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  EICKHOLT ROBERT A ,  LAUWERS KENNETH S ,  HANDLEY RICHARD S

IPC分类号： C07D305/00 ,  C07D321/00 ,  C07F5/02 ,  C12N9/96 ,  C12Q1/26 ,  G01N20060101 ,  G01N21/76 ,  G01N33/53 ,  G01N33/533 ,  G01N33/534

CPC分类号： C07F5/025 ,  G01N33/533 ,  Y10S436/904 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/206664

摘要： Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula (I) is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each R is independently selected from hydrogen, alkyl and aryl groups and can be joined together as a straight or branched alkylene chain forming a ring or as an aromatic ring. A detectable product compound of the formula Sig - OH or Sig -O>-

公开(公告)号：EP1429993A4

公开(公告)日：2008-08-13

申请号：EP02761074

申请日：2002-08-23

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  HANDLEY RICHARD S ,  SANDISON MARK D ,  LARKIN RANDALL K

IPC分类号： C01B13/02 ,  C08F8/06 ,  C09K3/00 ,  C01B13/00

CPC分类号： C01B13/02 ,  C08F8/18 ,  C08F8/40 ,  C08F8/26 ,  C08F212/08 ,  C08F212/14 ,  C08F212/36

摘要： Improved polymer-immobilized photosensitizer are disclosed as well as methods of preparing and using them. The polymer-immobilized photosensitizers comprise a cross-linked polymer backbone, a plurality of cationic ammonium or phosphonium groups covalently bound to the polymer backbone and an immobilized photosensitizer. The average total number of carbon atoms in the ammonium or phosphonium group is at least four and preferably at least 12. The photosensitizer can be either covalently or ionically bound to the polymer. Polymer-supported photosensitizers of the invention are unexpectedly superior in catalyzing the photosensitized oxidation of compounds containing carbon-carbon double bonds.

公开(公告)号：EP0675968A4

公开(公告)日：1997-11-26

申请号：EP93924928

申请日：1993-10-14

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI M HASHEM ,  HANDLEY RICHARD S

IPC分类号： G01N33/532 ,  C07D237/32 ,  C07H21/04 ,  C12Q1/28 ,  C12Q1/68 ,  G01N21/76 ,  G01N33/53 ,  G01N33/566

CPC分类号： C12Q1/28 ,  C12Q1/6816

摘要： A method and test kit using a hydroxyaryl cyclic diacylhydrazide, a peroxide and a peroxidase enzyme on a blotting membrane for detecting DNA, RNA or proteins (polypeptides) is described. The method and kit provide enhanced chemiluminescence in an assay because of the use of the membrane. The method and test kit is particularly useful in Western, Southern and Northern blotting type assays and DNA sequencing.

摘要翻译： 使用的羟基芳基环状diacylhydrazides一个，过氧化物和用于检测DNA，RNA或蛋白质（多肽）上的印迹膜过氧化物酶的方法和检验试剂盒进行说明。 所述方法和试剂盒提供了增强的化学发光法在由于使用膜组成。 该方法和检测试剂盒是西方，Southern和Northern印迹型测定和DNA测序是特别有用的。

公开(公告)号：EP1509601A4

公开(公告)日：2009-01-14

申请号：EP03731062

申请日：2003-05-15

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  DE SILVA RENUKA ,  SANDISON MARK D ,  HANDLEY RICHARD S

IPC分类号： C12N9/96 ,  C12P17/12 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/34 ,  G01N33/533

CPC分类号： C12Q1/28 ,  G01N33/533 ,  Y10S435/968

摘要： Methods of producing fluorescence from fluorogenic substrates reactive with a peroxidase enzyme are disclosed. Use of the methods in assays for peroxidase enzymes, peroxidase-labeled analytes are provided. Fluorogenic compounds, compositions and kits for reaction with peroxidase enzymes are described. Two modes of producing fluorescent compounds are described.

公开(公告)号：EP1781808A4

公开(公告)日：2007-08-29

申请号：EP04812308

申请日：2004-12-13

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  DESILVA RENUKA ,  CILLI NICOLE M ,  CRIPPS WILLIAM G ,  HANDLEY RICHARD S ,  O'CONNOR ELIZABETH A ,  REDDY LEKKALA V ,  SIRIPURAPU SARADA

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/1006 ,  C12N15/101 ,  C12Q1/6823

摘要： Solid phase materials for binding nucleic acids and methods of their use are disclosed. The materials feature a cleavable linker portion which can be cleaved to release bound nucleic acids. The solid phase materials comprise a solid support portion comprising a matrix selected from silica, glass, insoluble synthetic polymers, and insoluble polysaccharides to which is attached a nucleic acid binding portion for attracting and binding nucleic acids, the nucleic acid binding portion (NAB) being linked by a cleavable linker portion to the solid support portion. Preferred nucleic acid binding portions comprise a ternary or quaternary onium group. The materials can be in the form of microparticles, fibers, beads, membranes, test tubes or micowells and can further comprise a magnetic core portion. Methods of binding nucleic acids using the cleavable solid supports are disclosed as are their use in methods of isolating or purifying nucleic acids.

公开(公告)号：EP1353908A4

公开(公告)日：2004-01-28

申请号：EP01995974

申请日：2001-12-07

申请人： LUMIGEN INC

发明人： AKHAVAN-TAFTI HASHEM ,  EICKHOLT ROBERT A ,  HANDLEY RICHARD S

IPC分类号： C07B61/00 ,  C07D219/02 ,  C07D219/04 ,  C07D219/06 ,  C07D219/08 ,  C07D401/04 ,  C07D417/04

CPC分类号： C07D417/04 ,  C07D219/04 ,  C07D219/06

摘要： Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted intermendiates by formation of a bond between the nitrogen atom of the acridan ring and a carbon atom of another aromatic or heteroaromatic ring compound. The arylation reaction is catalyzed by a palladium catalyst. The N-arylacridan-carboxylic acid derivatives are useful in methods for producing light and in assays for peroxidase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.