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1.发明授权NOUVEAU PEPTIDE INTERAGISSANT AVEC LES PROTEINES ANTI-APOPTOTIQUES DE LA FAMILLE BCL-2 有权肽具有抗凋亡蛋白家族BCL-2相互作用
公开(公告)号：EP1651668B1
公开(公告)日：2009-07-15
申请号：EP04786256.0
申请日：2004-08-04
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , C07K14/4702
摘要： The invention relates to the identification of a novel peptide interacting with Bcl-2, Bcl-W and/or Bcl-XL anti-apoptotic proteins and to screening methods for identifying the modulators of said interactions.
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2.发明公开NOUVEAUX PEPTIDES INTERAGISSANT AVEC LES MEMBRES ANTI-APOPTOTIQUES DE LA FAMILLE DE PROTEINES BCL-2 ET UTILISATIONS 审中-公开与之交互的新肽及其用途抗凋亡Bcl-2蛋白家族成员
公开(公告)号：EP1844067A2
公开(公告)日：2007-10-17
申请号：EP06709202.3
申请日：2006-01-31
IPC分类号： C07K14/435 , C12N15/12 , C12N15/63 , G01N33/68 , G01N33/566 , G01N33/58 , A61K38/17 , A61P35/00
CPC分类号： C07K14/4747
摘要： The invention relates to the research and identification of novel peptides which interact with anti-apoptotic members of the family of Bcl-2 proteins by means of the double-hybrid system. More specifically, the invention relates to a method of screening and identifying modulators of the protein interaction between said novel peptides and the anti-apoptotic members of the family of Bcl-2 proteins. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death.
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3.发明公开NOUVEAU PEPTIDE INTERAGISSANT AVEC LES PROTEINES ANTI-APOPTOTIQUES DE LA FAMILLE BCL-2 有权肽具有抗凋亡蛋白家族BCL-2相互作用
公开(公告)号：EP1651668A2
公开(公告)日：2006-05-03
申请号：EP04786256.0
申请日：2004-08-04
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , C07K14/4702
摘要： The invention relates to the identification of a novel peptide interacting with Bcl-2, Bcl-W and/or Bcl-XL anti-apoptotic proteins and to screening methods for identifying the modulators of said interactions.
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4.发明公开UBIQUITIN SPECIFIC PROTEASES RESPONSIBLE FOR MCL-1 STABILITY AND USES THEREOF 审中-公开泛素蛋白酶FOR MCL-1稳定性和使用
公开(公告)号：EP2344666A2
公开(公告)日：2011-07-20
申请号：EP09799134.3
申请日：2009-10-29
CPC分类号： G01N33/5011 , A61K38/00 , C12Q1/37
摘要： Use of a polypeptide selected from the group consisting of USP13, USP26, USP38, USP42 or USP46 as a screening tool for an agent for treating cancer.
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公开(公告)号：EP3972649A2
公开(公告)日：2022-03-30
申请号：EP20730922.0
申请日：2020-05-19
发明人： BURGER, Matthew, T. , CHANRION, Maia , COLLAND, Frédéric , CSEKEI, Marton , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , HENLIN, Jean-Michel , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MCNEILL, Eric , PALERMO, Mark, G. , ROCCHETTI, Francesca , STARCK, Jérôme , YU, Bing , ZHANG, Qiang , PROSZENYÁK, Ágnes , SIPOS, Szabolcs , CHEN, Zhuoliang , NAKAJIMA, Katsumasa , D'ALESSIO, Joseph, Anthony , BLANKENSHIP, John, William
IPC分类号： A61K47/68
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公开(公告)号：EP3717482A1
公开(公告)日：2020-10-07
申请号：EP18814526.2
申请日：2018-11-28
发明人： KOTSCHY, András , WÉBER, Csaba , VASAS, Attila , KISS, Árpád , MOLNÁR, Balázs , STROFEK, Ágnes , KUN, Vilibald , MURRAY, James Brooke , MACIAS, Alba , LEWKOWICZ, Elodie , CHANRION, Maïa , IVANSCHITZ, Lisa , GENESTE, Olivier
IPC分类号： C07D471/04 , C07D473/30 , C07D495/04 , A61P35/00 , A61P37/00 , A61K31/519 , A61K31/52
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公开(公告)号：EP3313851B1
公开(公告)日：2019-11-06
申请号：EP16733379.8
申请日：2016-06-22
发明人： SZLÁVIK, Zoltán , KOTSCHY, András , CHANRION, Maïa , DEMARLES, Didier , GENESTE, Olivier , DAVIDSON, James Edward Paul , MURRAY, James Brooke , SIPOS, Szabolcs , PACZAL, Attila , BÁLINT, Balázs
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00 , A61P37/00
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公开(公告)号：EP3024826B1
公开(公告)日：2018-11-14
申请号：EP14741648.1
申请日：2014-07-22
发明人： DAVIDSON, James, Edward, Paul , MURRAY, James, Brooke , CHEN, I-Jen , WALMSLEY, Claire , DODSWORTH, Mark , MEISSNER, Johannes, W., G. , BROUGH, Paul , FEJES, Imre , TATAI, Janos , NYERGES, Miklos , KOTSCHY, Andras , SZLAVIK, Zoltan , GENESTE, Olivier , LE TIRAN, Arnaud , LE DIGUARHER, Thierry , HENLIN, Jean-Michel , STARCK, Jérôme-Benoît , GUILLOUZIC, Anne-Françoise , DE NANTEUIL, Guillaume
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4709 , C07D401/10 , C07D471/04 , A61P35/00 , A61P37/00 , C07D409/14 , A61K31/4725
CPC分类号： C07D401/14 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/675 , A61K45/06 , A61N5/10 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/65616 , A61K2300/00
摘要： Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：EP3027602B1
公开(公告)日：2018-06-13
申请号：EP14758604.4
申请日：2014-07-22
发明人： CASARA, Patrick , LE DIGUARHER, Thierry , HENLIN, Jean-Michel , STARCK, Jérôme-Benoît , LE TIRAN, Arnaud , DE NANTEUIL, Guillaume , GENESTE, Olivier , DAVIDSON, James Edward Paul , MURRAY, James Brooke , CHEN, I-Jen , WALMSLEY, Claire , GRAHAM, Christopher John , RAY, Stuart , MADDOX, Daniel , BEDFORD, Simon
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4709 , C07D401/10 , C07D471/04 , A61P35/00 , A61P37/00
CPC分类号： C07D401/10 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , A61K2300/00
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10.发明公开NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开新的二环衍生物，它们的制备方法和含有它们的药物组合物
公开(公告)号：EP3313817A1
公开(公告)日：2018-05-02
申请号：EP16730854.3
申请日：2016-06-22
发明人： BÁLINT, Balázs , CSÉKEI, Márton , SZABÓ, Zoltán , SZLÁVIK, Zoltán , KOTSCHY, András , CHANRION, Maïa , GENESTE, Olivier , CHEN, I-Jen , DAVIDSON, James Edward Paul , MURRAY, James Brooke , SIPOS, Szabolcs , ONDI, Levente , PROSZENYÁK, Ágnes
IPC分类号： C07D209/12 , C07D307/80 , C07D307/81 , C07D333/56 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/381 , A61K31/4355 , A61K31/437 , A61P35/00
摘要： Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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