公开(公告)号：EP2834357B1

公开(公告)日：2017-12-27

申请号：EP13717658.2

申请日：2013-04-04

申请人： Life Technologies Corporation ,  Thermo Fisher Scientific GENEART GmbH

发明人： KATZEN, Federico ,  CHESNUT, Jonathan ,  NOTKA, Frank ,  ARNOLD, Matthias ,  HOFF, Kevin ,  WHITESIDE, Stephen

IPC分类号： C12N15/10 ,  C12N9/22

CPC分类号： C12N15/1082 ,  C07K14/195 ,  C12N9/90 ,  C12N9/96 ,  C12N15/102 ,  C12N15/1086 ,  C12N15/1093 ,  C12N15/66 ,  C12Y599/01002

摘要： The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.

公开(公告)号：EP4401757A1

公开(公告)日：2024-07-24

申请号：EP22800037.8

申请日：2022-09-13

申请人： Life Technologies Corporation

发明人： CHESNUT, Jonathan ,  IHLAN, Alicia ,  POTTER, Robert ,  SONG, Youngzee

IPC分类号： A61K38/46 ,  C12N9/22 ,  C12N15/52 ,  C12N15/62 ,  C12N15/90

CPC分类号： C12N9/22 ,  C12N15/907 ,  C07K2319/8020130101 ,  A61K38/00 ,  C07K2319/8120130101

公开(公告)号：EP2834357A2

公开(公告)日：2015-02-11

申请号：EP13717658.2

申请日：2013-04-04

申请人： Life Technologies Corporation ,  Geneart AG

发明人： KATZEN, Federico ,  CHESNUT, Jonathan ,  NOTKA, Frank ,  ARNOLD, Matthias ,  HOFF, Kevin ,  WHITESIDE, Stephen

IPC分类号： C12N15/10 ,  C12N9/22

CPC分类号： C12N15/1082 ,  C07K14/195 ,  C12N9/90 ,  C12N9/96 ,  C12N15/102 ,  C12N15/1086 ,  C12N15/1093 ,  C12N15/66 ,  C12Y599/01002

摘要： The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.

公开(公告)号：EP2362912A1

公开(公告)日：2011-09-07

申请号：EP09850164.6

申请日：2009-11-13

申请人： Life Technologies Corporation

发明人： LAKSHMIPATHY, Uma ,  THYAGARAJAN, Bhaskar ,  CHESNUT, Jonathan ,  ANEST, Vasiliki ,  BENNETT, Robert ,  LIEU, Pauline ,  HANSON, George ,  THOMPSON, David ,  CHASE, Lucas ,  SHIPLEY, Gary ,  WILSON, Elizabeth

IPC分类号： C12N15/86

CPC分类号： C12N15/86 ,  C12N2710/16221 ,  C12N2710/16222 ,  C12N2710/16243 ,  C12N2799/022 ,  C12N2799/026 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2820/002 ,  C12N2820/007 ,  C12N2820/60

摘要： The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.