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    MICRONEEDLE AND MICRONEEDLE ARRAY
    2.
    发明公开
    MICRONEEDLE AND MICRONEEDLE ARRAY 审中-公开
    微针和微针场

    公开(公告)号：EP2842595A4

    公开(公告)日：2015-12-09

    申请号：EP13782340

    申请日：2013-04-24

    申请人： TEIJIN LTD ,  MEDRX CO LTD

    发明人： TOYOHARA KIYOTSUNA ,  TANAKA TAISHI ,  KOHNO KAZUTERU ,  ODA TAKASHI ,  MASAOKA KOICHI ,  KOBAYASHI KATSUNORI ,  ISHIBASHI MASAKI ,  HAMAMOTO HIDETOSHI

    IPC分类号： A61M37/00 ,  A61K9/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061

    摘要： A microneedle and a microneedle array which can support not only a drug but also a stabilizer and a thickener in large quantities and have excellent puncture property. The microneedle is used to administer a drug transdermally and comprises a top section, a shaft section and a base section, wherein (i) the tip apex angle (±) is 15 to 60°; (ii) the tip diameter (D 0 ) is 1 to 20 µm; (iii) the area (A 3 ) of the top surface of the base section is larger than the area (A 2 ) of the bottom surface of the shaft section; (iv) the following expressions (1) and (2) are satisfied H / D 4 ‰§ 3 (H is the overall height, and D 4 is the diameter of the bottom surface of the base section) ² ‰§ 90 - 0.5 �¢ ± (² is the angle formed between the side surface of the shaft section and the top surface of the base section, and ± is the tip apex angle.); and (v) a solid composition containing a drug is fixed to the side surface of the shaft section and the following expression (5) is satisfied. 10 �¢ ° ‰¦ ³ ‰¦ 60 �¢ ° (³ is the angle formed by tangent lines connecting the apex of the top section and the surface of the solid composition fixed to the side surface of the shaft section.)

    PROCESS FOR PRODUCING PAD BASE FOR TRANSDERMAL DRUG ADMINISTRATION, PAD BASE FOR TRANSDERMAL DRUG ADMINISTRATION AND NEEDLE
    3.
    发明公开
    PROCESS FOR PRODUCING PAD BASE FOR TRANSDERMAL DRUG ADMINISTRATION, PAD BASE FOR TRANSDERMAL DRUG ADMINISTRATION AND NEEDLE 审中-公开
    一种用于生产支持基地透皮药品监督管理局，PAD基地透皮药物管理局，针

    公开(公告)号：EP1632263A4

    公开(公告)日：2008-04-30

    申请号：EP04736595

    申请日：2004-06-10

    申请人： MEDRX CO LTD

    发明人： MAENOSONO SHINYA ,  SUZUKI YASUSHI ,  AKITOMO HIROSHI ,  HAMAMOTO HIDETOSHI ,  ISHIBASHI MASAKI

    IPC分类号： A61M37/00

    CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053

    摘要： In the conventional micropatch method, the skin is pricked with solid needles, and vibration is applied by means of a vibrator so as to increase the needle-skin interstice to thereby accomplish drug administration. In the invention, there are provided a pad base for transdermal drug administration whereby transdermal administration of a medicinal drug can be accomplished without need to apply vibration, and provided a process wherein the pad base can easily be produced. One end of each of metal thin wires is immersed in the vertical direction in a synthetic resin raw material solution so as to cause the synthetic resin raw material solution to adhere to the circumference of the metal thin wires. The synthetic resin raw material solution is hardened, and thereafter the metal thin wires are pulled out. Thus, there can be obtained a structure comprising adherent substrate (2) and, disposed erect on the skin side surface thereof, microneedles (1) being tubular and having bell-bottom outer wall. Medicinal drug charged in the hollow portion (3) of microneedles (1) can be injected in the skin, thereby effecting transdermal drug administration. Further, the microneedles (1) are resistant to breaking off because of the bell-bottom shaping.