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1.发明公开HYDROXYL PURINE COMPOUNDS AND APPLICATIONS THEREOF 审中-公开HYDROXYLPURINVERBINDUNGEN UND ANWENDUNGEN DAVON
公开(公告)号：EP3205652A4
公开(公告)日：2017-08-16
申请号：EP15848312
申请日：2015-09-22
发明人： WU LINGYUN , ZHANG PENG , ZHANG LI , LI JIAN , CHEN SHUHUI , LONG CHAOFENG , CHEN XIAOXIN , LIU ZHUOWEI
IPC分类号： C07D473/30 , A61K31/52 , A61P9/00 , A61P19/02 , A61P29/00
CPC分类号： A61K31/522 , A61K31/52 , C07D241/10 , C07D261/06 , C07D277/20 , C07D473/30
摘要： Hydroxyl purine compounds represented by formula ( I ), tautomers or pharmaceutically acceptable salts thereof, and applications thereof as PDE2 or TNF-± inhibitors.
摘要翻译： 由式（I）表示的羟基嘌呤化合物，其互变异构体或其药学上可接受的盐以及其作为PDE2或TNF-α抑制剂的应用。
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公开(公告)号：EP3252059A4
公开(公告)日：2018-07-11
申请号：EP16742768
申请日：2016-01-28
发明人： LUO WEI , DING CHARLES Z , HUANG ZHIGANG , CHEN SHUHUI
IPC分类号： C07D519/00 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61P31/04 , A61P31/06
CPC分类号： C07D519/00 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61P31/04 , A61P31/06
摘要： Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.
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公开(公告)号：EP3138843A4
公开(公告)日：2017-04-05
申请号：EP15786613
申请日：2015-04-21
发明人： WU LINGYUN , YAO YUANSHAN , CHEN ZHAOGUO , CHEN SHUHUI
IPC分类号： C07D487/04 , A61K31/4725 , A61K31/55 , A61P9/10 , A61P9/12 , A61P27/06 , C07D401/12 , C07D471/04
CPC分类号： C07D487/04 , A61K31/4725 , A61K31/55 , C07D401/12 , C07D471/04
摘要： The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明公开了一类作为RHO激酶抑制剂的异喹啉磺酰基衍生物及其药物组合物，并涉及其药学上可接受的用途。 具体而言，本发明涉及由式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：EP3287453A4
公开(公告)日：2018-02-28
申请号：EP16782661
申请日：2016-04-22
发明人： LONG CHAOFENG , CHEN SHUHUI , CHEN XIAOXIN , LUO YUNFU , LIU ZHUOWEI , PAN JIANFENG
IPC分类号： C07D413/10 , A61K31/422 , A61P9/10 , C07D233/60 , C07D401/10 , C07D413/06 , C07D413/08 , C07D413/14 , C07D417/10
CPC分类号： C07D233/60 , A61P9/10 , C07D401/10 , C07D413/06 , C07D413/08 , C07D413/10 , C07D413/14 , C07D417/10
摘要： Disclosed is an imidazole compound, in particular, the compound as shown in formula (I) and a pharmaceutically acceptable salt or tautomer thereof are disclosed.
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5.发明公开ANALOGUES OF 4H-PYRAZOLO[1,5- ]BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS 审中-公开类似物EINER 4H-PYRAZOLO [1,5-A] BENZIMIDAZOL-VERBINDUNG ALS PARP-HEMMER
公开(公告)号：EP3130592A4
公开(公告)日：2017-09-06
申请号：EP15777444
申请日：2015-03-30
申请人： HUBEI BIO-PHARMACEUTICAL IND TECH INST INC , HUMANWELL HEALTHCARE (GROUP) CO LTD , MEDSHINE DISCOVERY INC
发明人： DING ZHAOZHONG , CHEN SHUHUI , LI GANG , WANG CAILIN , ZHANG ZHIBO , TU RONGHUA , WANG CAILIN , YUE YANG , ZHANG ZHIBO , CHEN HAILIANG , SUN WENJIE , HUANG LU
IPC分类号： C07D487/04 , A61P3/10 , A61P9/10 , A61P25/00 , A61P29/00 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： Disclosed is a series of analogues of 4H-pyrazolo[1,5-a]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound as shown by formula (I) or a pharmaceutically acceptable salt thereof as a PARP inhibitor.
摘要翻译： 公开了一系列作为PARP抑制剂的4H-吡唑并[1,5-a]苯并咪唑化合物的类似物。 特别地，本发明公开了式（I）所示的化合物或其药学上可接受的盐作为PARP抑制剂。
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公开(公告)号：EP3169368A4
公开(公告)日：2017-08-09
申请号：EP15822852
申请日：2015-07-13
发明人： LI CHUN SING , LI JIAN , CANG YONG , CHEN SHUHUI , LI GANG , XU XIONGBIN , LU LUN
IPC分类号： A61K47/50 , A61K39/395 , A61P35/00
CPC分类号： A61K47/48715 , A61K47/48569 , A61K47/48584 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , A61K47/6889 , C07K16/2863 , C07K16/3015 , C07K2317/24
摘要： The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
摘要翻译： 本发明涉及含有酰胺替代物和连接细胞毒性药物与抗体的常规或新型溶酶体酶促可切割二肽单元的接头。 本发明还涉及衍生自这些酰胺替代物接头的ADC（抗体 - 药物缀合物）用于治疗癌症。
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7.发明公开
公开(公告)号：EP3279188A4
公开(公告)日：2018-02-07
申请号：EP16771408
申请日：2016-04-01
发明人： WANG JIANFEI , ZHANG JING , ZHANG LONG , ZHANG YANG , LI JIAN , CHEN SHUHUI
IPC分类号： C07D249/12 , A61K31/4196 , A61P7/00 , A61P19/06
CPC分类号： A61K31/4196 , C07D249/12 , Y02P20/544
摘要： Disclosed are two axially chiral isomers and pharmaceutically available salts thereof, preparation method therefor, and pharmaceutical use of the two axially chiral isomers or pharmaceutical compositions thereof.
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公开(公告)号：EP3150600A4
公开(公告)日：2017-04-05
申请号：EP15799888
申请日：2015-05-27
发明人： HE HAIYING , ZHOU KAI , QIN HUA , LI XIAOLIN , ZHOU YUEDONG , WANG XIAOFEI , CHI XUEMEI , LI JIAN , CHEN SHUHUI
IPC分类号： C07D471/04 , A61K31/519 , A61K31/527 , A61K31/5377 , A61P1/16 , A61P31/20 , C07D487/04 , C07D487/10 , C07D498/04
CPC分类号： C07D513/04 , A61K31/519 , A61K31/527 , A61K31/5377 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/04
摘要： Disclosed is a dihydropyrimido loop derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了作为HBV抑制剂的二氢嘧啶环衍生物，特别涉及式（I）所示的化合物或其药学上可接受的盐。
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9.发明公开IMIDAZOLE DERIVATIVE USED AS ANTIVIRAL AGENT AND USE THEREOF IN PREPARATION OF MEDICAMENT 审中-公开AS抗病毒药咪唑衍生物用在药物中的应用
公开(公告)号：EP3081569A4
公开(公告)日：2016-10-26
申请号：EP14870381
申请日：2014-11-11
发明人： HE HAIYING , SHI WEIHUA , JIANG ZHIGAN , HAN LIXIA , SUN JIKUI , LI JIAN , CHEN SHUHUI
IPC分类号： C07D491/107 , A61K31/4184 , A61K31/437 , A61P31/14 , C07D235/10 , C07D401/14 , C07D403/06 , C07D471/10 , C07D471/20 , C07D487/10 , C07D495/10 , C07D498/10 , C07F9/6558 , C07F9/6561
CPC分类号： C07D487/10 , A61K31/4184 , A61K31/437 , C07D403/06 , C07D471/10 , C07D471/18 , C07D471/20
摘要： Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present invention relates an imidazole derivative for treating respiratory syncytial virus infection.
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