公开(公告)号：EP0870199B1

公开(公告)日：2006-07-26

申请号：EP96943623.7

申请日：1996-12-10

申请人： Merck & Co., Inc.

发明人： CHAUNG, Lee-Yuh ,  FEIGHNER, Scott, D. ,  HOWARD, Andrew, D. ,  PONG, Sheng, S. ,  VAN DER PLOEG, Leonardus

IPC分类号： G01N33/566 ,  C12N15/87 ,  C12N15/63 ,  C07K14/715 ,  C12Q1/02

CPC分类号： G01N33/74 ,  C07K14/723 ,  C12Q1/6897 ,  G01N2333/726 ,  G01N2500/10

摘要： An assay for the detection of growth hormone secretagogue receptors and growth hormone secretagogue related receptors is described. As these receptors are a member of the G protein coupled receptors, a subunit of the G protein must be present in order for expression to be detected. A similar assay is described where the presence of growth hormone secretagogues are detected.

公开(公告)号：EP0870199A1

公开(公告)日：1998-10-14

申请号：EP96943623.0

申请日：1996-12-10

申请人： MERCK & CO., INC.

发明人： CHAUNG, Lee-Yuh ,  FEIGHNER, Scott, D. ,  HOWARD, Andrew, D. ,  PONG, Sheng, S. ,  VAN DER PLOEG, Leonardus

IPC分类号： G01N33 ,  C07K14 ,  C12N15 ,  C12Q1 ,  C12R1

CPC分类号： G01N33/74 ,  C07K14/723 ,  C12Q1/6897 ,  G01N2333/726 ,  G01N2500/10

摘要： An assay for the detection of growth hormone secretagogue receptors and growth hormone secretagogue related receptors is described. As these receptors are a member of the G protein coupled receptors, a subunit of the G protein must be present in order for expression to be detected. A similar assay is described where the presence of growth hormone secretagogues are detected.

公开(公告)号：EP1140968B9

公开(公告)日：2007-05-09

申请号：EP99963099.9

申请日：1999-12-16

申请人： Merck & Co., Inc.

发明人： HOWARD, Andrew, D. ,  MACNEIL, Douglas, J. ,  VAN DER PLOEG, Leonardus, H., T.

IPC分类号： C07K14/72

CPC分类号： C07K14/723

摘要： The present invention relates to DNA molecules encoding splice variants of the melanocortin-1 receptor (MC-R1) protein belonging to the rhodopsin sub-family of G-protein coupled receptors, recombinant vectors comprising DNA molecules encoding MC-R1B protein, recombinant host cells which contain a recombinant vector encoding MC-R1B, the human MC-R1B protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of MC-R1B proteins disclosed throughout this specification.

公开(公告)号：EP1620555A2

公开(公告)日：2006-02-01

申请号：EP04759849.5

申请日：2004-04-14

申请人： Merck & Co., Inc. ,  BANYU PHARMACEUTICAL CO., LTD.

发明人： TAN, Carina, P. ,  HOWARD, Andrew, D. ,  SANO, Hideki

IPC分类号： C12N15/12 ,  C12N15/63 ,  C07H21/04 ,  C07K14/47 ,  G01N33/566 ,  G01N33/567

CPC分类号： C07K14/70571 ,  C07K14/723 ,  G01N2333/70571

摘要： A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolated rhesus monkey bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or the cell cycle. Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.

摘要翻译： 已经分离，克隆和测序了恒河猴铃蟾肽受体亚型-3。 该受体是G蛋白家族受体的特征。 分离的恒河猴铃蟾肽受体亚型-3可用于筛选和鉴定可能有助于调节内分泌过程，代谢或细胞周期的新型铃蟾肽受体调节剂。 此类化合物可用于治疗由铃蟾肽受体亚型-3的失调表达引起的病症。

公开(公告)号：EP1157097A2

公开(公告)日：2001-11-28

申请号：EP00921344.8

申请日：2000-02-22

申请人： Merck & Co., Inc. ,  MERCK FROSST CANADA INC. ,  University of Toronto

发明人： HOWARD, Andrew, D. ,  O'NEILL, Gary, P. ,  O'DOWD, Brian ,  GEORGE, Susan

IPC分类号： C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/723

摘要： Human and rat DNAs encoding a novel G-protein coupled receptor, GPR54, as well as proteins encoded by the DNAs, are provided. Methods of identifying agonists and antagonists of GPR54 are also provided.

公开(公告)号：EP0876402A1

公开(公告)日：1998-11-11

申请号：EP96945183.0

申请日：1996-12-10

申请人： MERCK & CO., INC.

发明人： ARENA, Joseph, P. ,  CULLY, Doris, F. ,  FEIGHNER, Scott, D. ,  HOWARD, Andrew, D. ,  LIBERATOR, Paul, A. ,  SCHAEFFER, James, M. ,  VAN DER PLOEG, Leonardus

IPC分类号： G01N33 ,  C07B59 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12N15 ,  A61K38

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07B59/002

摘要： Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.

公开(公告)号：EP1086117B1

公开(公告)日：2007-02-21

申请号：EP99928453.2

申请日：1999-06-08

申请人： Merck & Co., Inc.

发明人： FEIGHNER, Scott, D. ,  PATCHETT, Arthur, A. ,  TAN, Carina ,  MCKEE, Karen ,  MACNEIL, Douglas ,  HOWARD, Andrew, D. ,  PONG, Sheng-Shung ,  SMITH, Roy, G.

IPC分类号： C07H21/04 ,  C07K14/705 ,  C12N15/09 ,  C12N15/63 ,  C12Q1/68

CPC分类号： C07K14/705

摘要： The motilin receptor has been isolated and cloned, and nucleic acid sequences are given. Two splice variants have been identified. Also, assays for motilin receptor ligands are given. The identification of the cloned motilin receptor may be used to screen and identify compounds which bind to the receptor for use in a variety of gastric conditions, including gastric motility disorders.

公开(公告)号：EP1276769A1

公开(公告)日：2003-01-22

申请号：EP01934903.4

申请日：2001-04-25

申请人： Merck & Co., Inc.

发明人： LIU, Qingyun ,  LYNCH, Kevin, R. ,  HOWARD, Andrew, D. ,  MELLIN, Theodore, N. ,  STRACK, Alison ,  VAN DER PLOEG, Leonardus, H., T. ,  WANG, Ruiping ,  JIANG, Qingping ,  WILLIAMS, David

IPC分类号： C07K14/72 ,  C12N15/16

CPC分类号： C07K14/70571 ,  C07K14/72 ,  C07K2319/00 ,  G01N33/6893 ,  G01N33/74 ,  G01N2500/00

摘要： A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain. Amino acid sequences of the human and rat forms, as well as their nucleic acid sequences are given.

公开(公告)号：EP1140968A1

公开(公告)日：2001-10-10

申请号：EP99963099.9

申请日：1999-12-16

申请人： Merck & Co., Inc.

发明人： HOWARD, Andrew, D. ,  MACNEIL, Douglas, J. ,  VAN DER PLOEG, Leonardus, H., T.

IPC分类号： C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12P21/06

CPC分类号： C07K14/723

摘要： The present invention relates to DNA molecules encoding splice variants of the melanocortin-1 receptor (MC-R1) protein belonging to the rhodopsin sub-family of G-protein coupled receptors, recombinant vectors comprising DNA molecules encoding MC-R1B protein, recombinant host cells which contain a recombinant vector encoding MC-R1B, the human MC-R1B protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of MC-R1B proteins disclosed throughout this specification.

摘要翻译： 本发明涉及编码属于G蛋白偶联受体的视紫红质亚族的黑皮质素-1受体（MC-R1）蛋白的剪接变体的DNA分子，包含编码MC-R1B蛋白的DNA分子的重组载体，重组宿主细胞 其包含编码MC-R1B的重组载体，由DNA分子编码的人MC-R1B蛋白，以及鉴定本说明书中公开的MC-R1B蛋白的选择性激动剂和拮抗剂的方法。

公开(公告)号：EP1097170A1

公开(公告)日：2001-05-09

申请号：EP99934025.0

申请日：1999-07-13

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  HOWARD, Andrew, D. ,  MCKEE, Karen, Kulju

IPC分类号： C07K14/705 ,  C12N15/12 ,  C12N5/10 ,  C12N15/63 ,  G01N33/566 ,  G01N33/50

CPC分类号： C07K14/705 ,  A61K38/00

摘要： This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R) and the neurotensin receptor (NT-R). These newly identified receptors are expressed in a diverse set of tissues. This invention also relates to nucleic acids encoding these receptors, and to the use of these receptors to identify ligands that modulate growth hormone release or other endocrine functions.