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1.发明公开HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS 有权PDE4抑制剂与HETEROBRÜCKENSUBSTITUIERTEM8 arylquinoline
公开(公告)号：EP1487797A1
公开(公告)日：2004-12-22
申请号：EP03744288.6
申请日：2003-03-17
发明人： GALLANT, Michel , LACOMBE, Patrick , DUBE, Daniel , DESCHENES, Denis , MACDONALD, Dwight , DUBE, Laurence
IPC分类号： C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D409/14 , C07D401/12 , C07D417/12 , C07D409/12 , C07D401/14 , C07D413/12 , C07D487/04 , A61K31/47 , A61K31/4709 , A61P11/00 , A61P25/00
CPC分类号： C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04
摘要： 8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one of the bridge atoms is not carbon, are PDE4 inhibitors.
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2.发明公开4-OXO-1-(3-SUBSTITUTED PHENYL-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXAMIDE PHOSPHODIESTERASE-4 INHIBITORS 有权4-氧代-1-（3-取代的苯基）-1,4-二氢-1,8-二氮杂萘-3-羧酸酰胺ALSPHOSHODIESTERASE-4抑制剂
公开(公告)号：EP1565464A1
公开(公告)日：2005-08-24
申请号：EP03775029.6
申请日：2003-11-19
发明人： DUBE, Daniel , GALLANT, Michel , LACOMBE, Patrick , ASPIOTIS, Renee , DUBE, Laurence , GIRARD, Yves , MACDONALD, Dwight
IPC分类号： C07D471/04 , A61K31/4375 , A61P25/00 , C07D221/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I):or a pharmaceutically acceptable salt thereof, are phosphodiesterase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognition.
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公开(公告)号：EP1404330B1
公开(公告)日：2005-06-01
申请号：EP02742600.6
申请日：2002-06-26
发明人： DUBE, Daniel , GIRARD, Yves , MACDONALD, Dwight , MASTRACCHIO, Anthony , GALLANT, Michel , LACOMBE, Patrick , DESCHENES, Denis
IPC分类号： A61K31/47 , C07D215/12 , C07D401/10 , C07D405/10 , C07D417/12 , C07F9/60 , C07F9/6571 , C07D403/10 , C07D413/10 , C07D417/10 , C07D405/14 , A61P11/06 , A61P29/00 , A61P17/06
CPC分类号： C07D401/08 , C07D215/12 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/14 , C07D413/08 , C07D417/08 , C07D417/12 , C07F9/60 , C07F9/657181
摘要： 8-arylquinolines of formula(I) wherein the aryl group at the 8-position contains a meta two atom bridge to an optionally substituted phenyl or pyridyl group, are PDE4 inhibitors useful to treat asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, and other diseases. R1-R7 and Ar are as in claim 1.
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公开(公告)号：EP1404330A1
公开(公告)日：2004-04-07
申请号：EP02742600.6
申请日：2002-06-26
发明人： DUBE, Daniel , GIRARD, Yves , MACDONALD, Dwight , MASTRACCHIO, Anthony , GALLANT, Michel , LACOMBE, Patrick , DESCHENES, Denis
IPC分类号： A61K31/47 , C07D215/12 , C07D401/10 , C07D405/10 , C07D417/12 , C07F9/60 , C07F9/6571 , C07D403/10 , C07D413/10 , C07D417/10 , C07D405/14 , A61P11/06 , A61P29/00 , A61P17/06
CPC分类号： C07D401/08 , C07D215/12 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/14 , C07D413/08 , C07D417/08 , C07D417/12 , C07F9/60 , C07F9/657181
摘要： 8-arylquinolines of formula(I) wherein the aryl group at the 8-position contains a meta two atom bridge to an optionally substituted phenyl or pyridyl group, are PDE4 inhibitors useful to treat asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, and other diseases. R1-R7 and Ar are as in claim 1.
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5.发明授权
公开(公告)号：EP1363635B1
公开(公告)日：2009-04-15
申请号：EP01273908.2
申请日：2001-12-14
发明人： VAILAYA, Anant , CONLON, David, A. , HO, Guo-Jie , MACDONALD, Dwight , PERRIER, Helene , THIBERT, Roch , KWONG, Elizabeth , CLAS, Sophie-Dorothee
IPC分类号： A61K31/47 , C07D215/12 , C07D215/14 , C07D401/10 , C07D413/10 , C07D417/10 , A61P11/00
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D413/10 , C07D417/10
摘要： Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
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公开(公告)号：EP1592419A1
公开(公告)日：2005-11-09
申请号：EP03776698.7
申请日：2003-11-19
发明人： DUBE, Daniel , GALLANT, Michel , LACOMBE, Patrick , GIRARD, Yves , MACDONALD, Dwight , FRIESEN, Richard , DUCHARME, Yves , COTE, Bernard , BLOUIN, Marc , MARTINS, Evelyn , GUAY, Daniel , GIRARD, Mario , FRENETTE, Richard , LALIBERTE, Sebastien , ROBICHAUD, Annette , MASTRACCHIO, Anthony , PERRIER, Helene , HAMEL, Pierre
IPC分类号： A61K31/277 , A61K31/44 , A61K31/4375 , A61K31/47 , A61P25/00 , A61P25/28
CPC分类号： A61K31/4709 , A61K31/277 , A61K31/4375 , A61K31/44 , A61K31/47
摘要： The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.
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7.发明公开
公开(公告)号：EP1363635A1
公开(公告)日：2003-11-26
申请号：EP01273908.2
申请日：2001-12-14
发明人： VAILAYA, Anant , CONLON, David, A. , HO, Guo-Jie , MACDONALD, Dwight , PERRIER, Helene , THIBERT, Roch , KWONG, Elizabeth , CLAS, Sophie-Dorothee
IPC分类号： A61K31/47 , C07D215/12 , C07D215/14 , C07D401/10 , C07D413/10 , C07D417/10 , A61P11/00
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D413/10 , C07D417/10
摘要： Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
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