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公开(公告)号：EP1482924A2
公开(公告)日：2004-12-08
申请号：EP03716238.5
申请日：2003-02-28
发明人： BAYLY, Christopher, I. , BLACK, Cameron , LEGER, Serge , LI, Chun Sing , MCKAY, Dan , MELLON, Christophe , GAUTHIER, Jacques Yves , LAU, Cheuk , THERIEN, Michel , TRUONG, Vouy-Linh , GREEN, Michael, J. , HIRSCHBEIN, Bernard, L. , JANC, James, W. , PALMER, James, T. , BASKARAN, Chitra
IPC分类号： A61K31/275
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
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公开(公告)号：EP0739340A1
公开(公告)日：1996-10-30
申请号：EP95903727.0
申请日：1994-12-19
发明人： DUCHARME, Yves , GAUTHIER, Jacques, Yves Apartment 2 , PRASIT, Petpiboon , LEBLANC, Yves , WANG, Zhaoyin , LEGER, Serge , THERIEN, Michel
IPC分类号： A61K31 , A61P29 , A61P43 , C07C311 , C07C317 , C07D275 , C07D277 , C07D307 , C07D333 , C07D405
CPC分类号： C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04
摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式（I）化合物。 本发明还包括用于治疗包含式（I）化合物的环加氧酶-2介导的疾病的某些药物组合物。
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公开(公告)号：EP0705254B1
公开(公告)日：1998-05-06
申请号：EP94918259.6
申请日：1994-06-09
发明人： DUCHARME, Yves , GAUTHIER, Jacques, Yves , PRASIT, Petpiboon , LEBLANC, Yves , WANG, Zhaoyin , LEGER, Serge , THERIEN, Michel
IPC分类号： C07D277/02 , C07D275/02 , C07D307/02 , C07D333/04 , A61K31/00
CPC分类号： C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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4.发明公开
公开(公告)号：EP0778834A1
公开(公告)日：1997-06-18
申请号：EP95928912.0
申请日：1995-08-24
IPC分类号： C07D333 , A61K31 , A61P1 , A61P7 , A61P11 , A61P13 , A61P15 , A61P25 , A61P29 , A61P43 , C07C311 , C07C317 , C07D209 , C07D307 , C07D409 , C07D413 , C07D417 , C07D493 , C07D495
CPC分类号： C07D307/79 , C07D209/10 , C07D333/18 , C07D495/04
摘要： The invention encompasses the novel compound of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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5.发明公开3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS 失效3,4-二芳基-2-羟基-2,5-二氢呋喃作为COX-2抑制剂的活性成分的前体
公开(公告)号：EP0904269A1
公开(公告)日：1999-03-31
申请号：EP96934267.0
申请日：1996-10-29
发明人： BLACK, Cameron , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin , HAMEL, Pierre , HAN, Yongxin , HUGHES, Gregory
IPC分类号： C07D317 , A61K31 , A61P29 , A61P43 , C07C317 , C07C323 , C07D213 , C07D307 , C07D405 , C07D409 , C07D417 , C07F9
CPC分类号： C07D307/32 , C07C317/22 , C07C323/64 , C07D213/34 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/94 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07F9/117
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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6.发明公开
公开(公告)号：EP0828724A1
公开(公告)日：1998-03-18
申请号：EP96913412.0
申请日：1996-05-15
发明人： BLACK, Cameron , GRIMM, Erich , WANG, Zhaoyin , LEGER, Serge
IPC分类号： C07D333 , A61K31 , A61P1 , A61P7 , A61P13 , A61P15 , A61P25 , A61P29 , A61P35 , A61P43 , C07C317 , C07D307 , C07D405 , C07D407 , C07D409 , C07D417
CPC分类号： C07D405/04 , C07C317/44 , C07D307/60 , C07D307/64 , C07D407/04 , C07D409/04 , C07D417/04
摘要： The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
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公开(公告)号：EP0705254A1
公开(公告)日：1996-04-10
申请号：EP94918259.0
申请日：1994-06-09
发明人： DUCHARME, Yves , GAUTHIER, Jacques, Yves , PRASIT, Petpiboon , LEBLANC, Yves , WANG, Zhaoyin , LEGER, Serge , THERIEN, Michel
IPC分类号： C07C , C07D333 , A61K31 , A61P1 , A61P7 , A61P11 , A61P15 , A61P17 , A61P19 , A61P21 , A61P25 , A61P29 , A61P31 , A61P35 , A61P43 , C07C13 , C07C305 , C07C307 , C07C311 , C07C317 , C07C323 , C07D207 , C07D275 , C07D277 , C07D307 , C07D309 , C07D405 , C07D407 , C07D409 , C07D413 , C07D417 , C07D503 , C07F9
CPC分类号： C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式（I）化合物。 本发明还包括用于治疗包含式（I）化合物的环加氧酶-2介导的疾病的某些药物组合物。
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8.发明公开DIARYL-5-ALKYL-5-METHYL-2(5H)-FURANONES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS 审中-公开碳酸二芳基-5-烷基-5-甲基-2（5H） - 呋喃酮作为选择性COX-2抑制剂
公开(公告)号：EP1028951A1
公开(公告)日：2000-08-23
申请号：EP98949848.0
申请日：1998-10-27
发明人： WANG, Zhaoyin , LEGER, Serge , GRIMM, Erich
IPC分类号： C07D307/58 , A61K31/34
CPC分类号： C07D307/58
摘要： The invention encompasses compounds of Formula (I) as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I), e.g. (5R)-3-(3,4-difluorophenyl)-5-ethyl-5-methyl-4-[4-(methylsulfonyl)phenyl]-2,5-dihydro-2-furanone.
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公开(公告)号：EP0882016A1
公开(公告)日：1998-12-09
申请号：EP97900910.0
申请日：1997-01-29
发明人： BLACK, Cameron , GRIMM, Erich , HUGHES, Greg , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin
CPC分类号： C07D405/12 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07D307/58 , C07D307/60 , C07D307/64 , C07D307/66 , C07D307/94
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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10.发明授权FURO 3,2-b]PYRIDINES AND THIENO 3,2-b]PYRIDINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 失效呋喃并[3,2-b]吡啶和噻吩并[3,2-b]吡啶作为抑制剂白三烯生物合成
公开(公告)号：EP0691972B1
公开(公告)日：1998-07-01
申请号：EP94908907.2
申请日：1994-03-10
发明人： LEGER, Serge , HUTCHINSON, John H.
IPC分类号： C07D491/048 , A61K31/44 , C07D495/04 , A61K31/425
CPC分类号： C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds having formula (I) are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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