公开(公告)号：EP0983226A1

公开(公告)日：2000-03-08

申请号：EP98922757.4

申请日：1998-04-21

申请人： MERCK PATENT GmbH

发明人： LARDY, Claude ,  BARBANTON, Jacques ,  DUMAS, Hervé ,  COLLONGES, François ,  DURBIN, Philipp

IPC分类号： C07C205/45 ,  C07C255/56 ,  A61K31/12 ,  A61K31/16 ,  C07C233/33 ,  C07C233/76 ,  C07C225/22 ,  C07C235/56 ,  C07C233/61 ,  C07C235/24 ,  C07C237/22 ,  C07C311/21 ,  C07D209/48 ,  C07D333/70 ,  C07C311/60 ,  C07D333/20 ,  C07D211/76 ,  C07C323/22 ,  C07C317/24 ,  C07C235/38

CPC分类号： C07D209/48 ,  C07C205/45 ,  C07C225/22 ,  C07C233/33 ,  C07C233/61 ,  C07C233/76 ,  C07C235/24 ,  C07C235/56 ,  C07C237/22 ,  C07C255/56 ,  C07C311/21 ,  C07C311/60 ,  C07C317/24 ,  C07C323/22 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2602/08 ,  C07D307/84 ,  C07D333/22 ,  C07D333/56 ,  C07D333/62 ,  C07D333/68

摘要： The compounds of formula (I) in which: A represents C6-C10 aryl or an optionally aromatic three- to ten-membered heterocycle; X represents halogen, cyano, C1-C7 alkyl, trifluoromethyl, C2-C7 alkoxy or trifluoromethoxy; p is chosen from 0, 1, 2, 3, 4 and 5; Z represents a bond, -CO-NH-, -SO2-NH-, C2-C7 alkenylene, sulfur, sulfinyl, or sulfonyl; n represents 0 or 1; R1, R2, R3, E, are as defined in Claim 1, are aldose reductase inhibitors.

摘要翻译： 本发明涉及下式的化合物：其中R1，R2，R3，E，A，X，Z，p和n如本文所定义。 这些化合物是醛糖还原酶抑制剂。

公开(公告)号：EP1636218B1

公开(公告)日：2009-03-25

申请号：EP04735742.1

申请日：2004-06-02

申请人： Merck Patent GmbH

发明人： GUEDAT, Philippe ,  COLLONGES, François ,  DUMAS, Hervé ,  ORTHOLAND, Jean-Yves ,  DECERPRIT, Jacques ,  BARBANTON, Jacques ,  FOSTER, Richard, J. ,  KANE, Peter ,  WENDT, Bernd

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D491/10 ,  A61K31/454 ,  A61P3/04

CPC分类号： C07D417/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/10 ,  C07D495/04

摘要： The present invention relates to thiazolylpiperidine derivatives of the gen­eral formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2’, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper­triglyceridaemia, hypercholesterolaemia and dyslipidaemia.

公开(公告)号：EP1636218A1

公开(公告)日：2006-03-22

申请号：EP04735742.1

申请日：2004-06-02

申请人： Merck Patent GmbH

发明人： GUEDAT, Philippe ,  COLLONGES, François ,  DUMAS, Hervé ,  ORTHOLAND, Jean-Yves ,  DECERPRIT, Jacques ,  BARBANTON, Jacques ,  FOSTER, Richard, J. ,  KANE, Peter ,  WENDT, Bernd

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D491/10 ,  A61K31/454 ,  A61P3/04

CPC分类号： C07D417/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/10 ,  C07D495/04

摘要： The present invention relates to thiazolylpiperidine derivatives of the gen­eral formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2’, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper­triglyceridaemia, hypercholesterolaemia and dyslipidaemia.

公开(公告)号：EP1554263A1

公开(公告)日：2005-07-20

申请号：EP03809266.4

申请日：2003-10-01

申请人： MERCK PATENT GmbH

发明人： DUMAS, Hervé ,  BARBANTON, Jacques ,  COLLONGES, Francois ,  DECERPRIT, Jacques ,  ORTHOLAND, Jean-Yves ,  BENZIES, David, W., M. ,  CAMERON, Stuart ,  FOSTER, Richard, J. ,  GUESSREGEN, Stefan, M. ,  KANE, Peter ,  LAINTON, Julia, A., H. ,  ROBERTSON, Avril, A., B. ,  WENDT, Bernd ,  WARNE, Mark, R.

IPC分类号： C07D317/46 ,  C07D319/20 ,  C07D319/18 ,  C07D321/10 ,  C07D405/12 ,  C07F7/18 ,  C07C65/24 ,  C07C65/34 ,  C07C271/12 ,  A61K31/357 ,  A61K31/36 ,  A61P3/10

CPC分类号： C07D405/12 ,  C07C65/24 ,  C07C65/34 ,  C07C69/007 ,  C07C69/616 ,  C07C271/12 ,  C07D317/46 ,  C07D319/18 ,  C07D319/20 ,  C07D321/10 ,  C07F7/1856

摘要： The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof in all proportions, which can be used in the treatment of dyslipidaemia, and to pharmaceutical compositions comprising them.