公开(公告)号：EP3087060A4

公开(公告)日：2017-06-14

申请号：EP14873215

申请日：2014-12-17

申请人： MERCK SHARP & DOHME ,  MSD R & D (CHINA) CO LTD

发明人： SHEN DONG-MING ,  EGBERTSON MELISSA ,  BERGER RICHARD ,  QIAN XIAOXIA ,  QIAN YIMIN ,  HARPER BART ,  YANG MENG ,  GUO ZACK ZHI QIANG ,  RADA VANESSA L ,  WANG DEPING ,  CERNAK TIMOTHY A ,  SINZ CHRISTOPHER J ,  WANG MING ,  WILSON JONATHAN E ,  XU SHIMIN

IPC分类号： C07D239/36 ,  A61K31/513 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D239/36 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.

摘要翻译： 公开了可用作治疗剂以治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统病症的式（I）的嘧啶甲酰胺化合物，其药物组合物及其用途。

公开(公告)号：EP3294297A1

公开(公告)日：2018-03-21

申请号：EP16796942

申请日：2016-05-10

申请人： MERCK SHARP & DOHME

发明人： SHEN DONG MING ,  QIAN XIAOXIA ,  HARPER BART ,  YANG MENG ,  WANG DEPING ,  BO YINGJIAN

IPC分类号： A61K31/505 ,  A61K31/513 ,  C07D233/96 ,  C07D239/24

CPC分类号： C07D487/04 ,  C07D239/38 ,  C07D239/42 ,  C07D239/52 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention is directed to pyrimidinone amide compounds which may be useful as therapeutic agents for the treatment of central nervous system and/or peripheral disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Alzheimer's, cognitive impairment, anxiety, depression, migraines, or Huntington's disease, Parkinson's disease, Parkinson's disease dementia (PDD), and other diseases associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：EP2464228A4

公开(公告)日：2013-01-23

申请号：EP10808529

申请日：2010-08-03

申请人： MERCK SHARP & DOHME

发明人： WOOD HAROLD B ,  ADAMS ALAN D ,  SZEWCZYK JASON W ,  ZHANG YONG ,  YANG MENG

IPC分类号： A61K31/445 ,  A61P3/10 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D413/14

摘要： Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

摘要翻译： 式I的取代的环丙基的化合物：是游离缺失盘用于治疗或预防2型糖尿病和类似的条件是有用的。 药学上可接受的盐也包括在内。 该化合物作为G蛋白偶联受体的激动剂是有用GPR第一百十九

公开(公告)号：EP3285581A1

公开(公告)日：2018-02-28

申请号：EP16769472

申请日：2016-03-21

申请人： MERCK SHARP & DOHME

发明人： SHEN DONG-MING ,  YANG MENG ,  CRESPO ALEJANDRO ,  WILSON JONATHAN E ,  MCCRACKEN TROY ,  WANG DEPING ,  PARKER DANN ,  GUO ZACK ZHIQIANG

IPC分类号： A01N43/90 ,  A61K31/535

CPC分类号： C07D403/04 ,  C07D401/14 ,  C07D405/14

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.