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    ERK INHIBITORS
    1.
    发明公开
    ERK INHIBITORS 审中-公开

    公开(公告)号：EP3233859A4

    公开(公告)日：2018-06-13

    申请号：EP15870726

    申请日：2015-12-10

    申请人： MERCK SHARP & DOHME ,  MSD R & D CHINA CO LTD

    发明人： SLOMAN DAVID L ,  WITTER DAVID ,  MANSOOR UMAR FARUK

    IPC分类号： C07D471/04

    CPC分类号： C07D498/18 ,  A61K31/437 ,  A61K31/444 ,  C07D471/18 ,  C07D471/22

    摘要： The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).

    ERK INHIBITORS
    3.
    发明公开
    ERK INHIBITORS 审中-公开
    ERK-缝边

    公开(公告)号：EP3082810A4

    公开(公告)日：2017-05-10

    申请号：EP14871205

    申请日：2014-12-12

    申请人： MERCK SHARP & DOHME

    发明人： LIPFORD KATHRYN ,  FALCONE DANIELLE ,  SLOMAN DAVID L ,  WITTER DAVID J

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K45/06 ,  A61K2300/00

    摘要： Disclosed are the ERK inhibitors of formula (1.0) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0). This invention provides compounds that are ERK inhibitors (i.e., ERK2 inhibitors). This invention also provides a pharmaceutical composition comprising an effective amount of at least one (e.g., 1) compound of formula (1.0) and a pharmaceutically acceptable carrier.

    摘要翻译： 公开了式（1.0）的ERK抑制剂及其药学上可接受的盐。 还公开了使用式（1.0）化合物治疗癌症的方法。 本发明提供了ERK抑制剂（即ERK2抑制剂）的化合物。 本发明还提供了包含有效量的至少一种（例如1种）式（1.0）化合物和药学上可接受的载体的药物组合物。