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1.发明公开USE OF INHIBITORS OF CYCLOOXYGENASE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 失效抑制剂在神经变性疾病的治疗CYCOOXYGENASE USE
公开(公告)号：EP0785778A1
公开(公告)日：1997-07-30
申请号：EP95933509.0
申请日：1995-10-09
发明人： DUCHARME, Yves , GAUTHIER, Jacques, Yves , PRASIT, Petpiboon , LEBLANC, Yves , WANG, Zhaoyin , LEGER, Serge , THERIEN, Michel , HILL, Raymond, George , SIRINATHSINGHJI, Dalip, Jaicaran, Sastri
CPC分类号： A61K31/426 , A61K31/10 , A61K31/341 , A61K31/381 , A61K31/425
摘要： The invention describes a method of treating neurodegenerative disorders such as Alzheimer's Disease by using a COX-2 inhibitor.
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2.发明公开PHOSPHONIC ACID BIARYL DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) 审中-公开PHOSPHONSÄUREDIARYLERIVATEAS蛋白酪氨酸磷酸酶抑制剂（PTP-1B）
公开(公告)号：EP1244677A1
公开(公告)日：2002-10-02
申请号：EP00986932.2
申请日：2000-12-21
发明人： LAU, Cheuk, Kun , BAYLY, Christopher , GAUTHIER, Jacques, Yves , LEBLANC, Yves , LI, Chun, Sing , ROY, Patrick , THERIEN, Michel , WANG, Zhaoyin
IPC分类号： C07F9/38 , A61K31/66 , C07F9/553 , C07F9/6539 , C07F9/6518 , C07F9/6524 , C07F9/653 , C07F9/6541 , C07F9/6506
CPC分类号： C07F9/65583 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
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3.发明公开ARYL SUBSTITUTED 5,5 FUSED AROMATIC NITROGEN COMPOUNDS AS ANTI-INFLAMMATORY AGENTS 失效芳基取代的5,5-连接的芳族硝基化合物用作抗炎活性成分
公开(公告)号：EP0802917A1
公开(公告)日：1997-10-29
申请号：EP96900215.0
申请日：1996-01-10
发明人： GAUTHIER, Jacques, Yves , LAU, Cheuk, K. , LEBLANC, Yves , LI, Chun-Sing , ROY, Patrick , THERIEN, Michel , WANG, Zhaoyin
CPC分类号： C07D487/04 , C07D513/04
摘要： The invention encompasses the novel compound of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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4.发明公开
公开(公告)号：EP0699188A1
公开(公告)日：1996-03-06
申请号：EP94916105.0
申请日：1994-05-19
发明人： LABELLE, Marc , LEBLANC, Yves , BELLEY, Michel , GRIMM, Erich, L. , GUAY, Daniel , XIANG, Yi, Bin
CPC分类号： C07D215/18
摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
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5.发明公开PHOSPHONIC AND CARBOXYLIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B (PTP-1B) 审中-公开膦的衍生物和羧基的酸作为抑制剂的蛋白酪氨酸磷酸酶-1B（PTP-1B）
公开(公告)号：EP1181309A1
公开(公告)日：2002-02-27
申请号：EP00929175.8
申请日：2000-05-12
发明人： LEBLANC, Yves , DUFRESNE, Claude , ROY, Patrick , WANG, Zhaoyin
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0202 , C07K5/06191 , C07K5/0827
摘要： The invention encompasses compounds represented by formula (I) as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.
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6.发明公开
公开(公告)号：EP0863891A1
公开(公告)日：1998-09-16
申请号：EP96932417.0
申请日：1996-10-09
发明人： BELLEY, Michel , GAUTHIER, Jacques, Y. , GRIMM, Erich , LEBLANC, Yves , LI, Chung-Sing , THERIEN, Michel , BLACK, Cameron , LAU, Cheuk-Kun , PRASIT, Petpiboon , ROY, Patrick
IPC分类号： C07D333 , A61K31 , A61P25 , A61P29 , A61P43 , C07C317 , C07D213 , C07D307 , C07D405 , C07D407 , C07D409 , C07D417 , C07D471 , C07D491 , C07D495 , C07D498 , C07D513
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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公开(公告)号：EP0739340A1
公开(公告)日：1996-10-30
申请号：EP95903727.0
申请日：1994-12-19
发明人： DUCHARME, Yves , GAUTHIER, Jacques, Yves Apartment 2 , PRASIT, Petpiboon , LEBLANC, Yves , WANG, Zhaoyin , LEGER, Serge , THERIEN, Michel
IPC分类号： A61K31 , A61P29 , A61P43 , C07C311 , C07C317 , C07D275 , C07D277 , C07D307 , C07D333 , C07D405
CPC分类号： C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04
摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式（I）化合物。 本发明还包括用于治疗包含式（I）化合物的环加氧酶-2介导的疾病的某些药物组合物。
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8.发明公开PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) 审中-公开膦酸衍生物作为蛋白的抑制剂酪氨酸磷酸酶1B（PTP-1B）
公开(公告)号：EP1244678A1
公开(公告)日：2002-10-02
申请号：EP00986935.5
申请日：2000-12-21
发明人： LEBLANC, Yves , DUFRESNE, Claude , GAUTHIER, Jacques, Yves , LAU, Cheuk, Kun , LI, Chun, Sing , ROY, Patrick , THERIEN, Michel , SCHEIGETZ, John , WANG, Zhaoyin
IPC分类号： C07F9/38
CPC分类号： C07F9/6539 , C07F9/3882 , C07F9/4075 , C07F9/4087 , C07F9/65188 , C07F9/65318
摘要： The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
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公开(公告)号：EP0737196A1
公开(公告)日：1996-10-16
申请号：EP95904990.0
申请日：1994-12-22
发明人： YOUNG, Robert, N. , LABELLE, Marc , LEBLANC, Yves , LAU, Cheuk, K. , DUFRESNE, Claude , GAREAU, Yves , XIANG, Yi, Bin
CPC分类号： C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
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公开(公告)号：EP0705254A1
公开(公告)日：1996-04-10
申请号：EP94918259.0
申请日：1994-06-09
发明人： DUCHARME, Yves , GAUTHIER, Jacques, Yves , PRASIT, Petpiboon , LEBLANC, Yves , WANG, Zhaoyin , LEGER, Serge , THERIEN, Michel
IPC分类号： C07C , C07D333 , A61K31 , A61P1 , A61P7 , A61P11 , A61P15 , A61P17 , A61P19 , A61P21 , A61P25 , A61P29 , A61P31 , A61P35 , A61P43 , C07C13 , C07C305 , C07C307 , C07C311 , C07C317 , C07C323 , C07D207 , C07D275 , C07D277 , C07D307 , C07D309 , C07D405 , C07D407 , C07D409 , C07D413 , C07D417 , C07D503 , C07F9
CPC分类号： C07D275/02 , C07C311/29 , C07C311/46 , C07C311/49 , C07C317/24 , C07C2601/08 , C07D277/26 , C07D307/38 , C07D307/58 , C07D333/18 , C07D333/38 , C07D405/04
摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式（I）化合物。 本发明还包括用于治疗包含式（I）化合物的环加氧酶-2介导的疾病的某些药物组合物。
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