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1.发明公开LAMINATED TISSUE GRAFTS COMPOSED OF WHARTON'S JELLY AND METHODS OF MAKING AND USING THE SAME 有权从华通氏胶和方法层压织物移植的生产和使用
公开(公告)号：EP2675279A1
公开(公告)日：2013-12-25
申请号：EP12747175.3
申请日：2012-02-13
申请人： MIMEDX Group Inc.
IPC分类号： A01N63/00
摘要： Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.
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公开(公告)号：EP3189731B1
公开(公告)日：2020-01-29
申请号：EP16203661.0
申请日：2008-09-08
申请人： MiMedx Group, Inc.
发明人： DANIEL, John , TOFE, Robert , SPENCER, Randall , RUSSO, John
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3.发明公开
公开(公告)号：EP2884944A1
公开(公告)日：2015-06-24
申请号：EP13830009.0
申请日：2013-08-14
申请人： MiMedx Group, Inc.
发明人： KOOB, Thomas J. , TOFE, Robert , CHEN, Elizabeth
摘要： Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
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公开(公告)号：EP3689421A1
公开(公告)日：2020-08-05
申请号：EP20153610.9
申请日：2008-09-08
申请人： MiMedx Group, Inc.
发明人： DANIEL, John , TOFE, Robert , SPENCER, Randall , RUSSO, John
摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located on top of and within the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high levels of laminin-5, a cell adhesion bio-active factor shown to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
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5.发明公开MICRONIZED COMPOSITIONS COMPOSED OF BONE GRAFTS AND METHODS OF MAKING AND USING THE SAME 审中-公开从骨移植复合微粉化组合物及其生产及其用途方法
公开(公告)号：EP2904094A2
公开(公告)日：2015-08-12
申请号：EP13844862.6
申请日：2013-10-07
申请人： MIMEDX Group Inc.
发明人： DANIEL, John , SPENCER, Randall , TOFE, Robert
IPC分类号： C12N5/07
CPC分类号： A61L27/3604 , A61L27/3608 , A61L2400/06 , A61L2430/02 , A61L2430/24
摘要： Described herein are compositions composed of micronized particles derived from one or more components present in placental tissue in combination with one or more bone grafts. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
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公开(公告)号：EP3744336A1
公开(公告)日：2020-12-02
申请号：EP20171466.4
申请日：2012-02-13
申请人： MiMedx Group, Inc.
发明人： MORSE, Brenda S. , SITH, Somaly , SPENCER, Randall , RAY, Steven , DANIEL, John , TOFE, Robert
摘要： Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
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公开(公告)号：EP2884944B1
公开(公告)日：2020-10-07
申请号：EP13830009.0
申请日：2013-08-14
申请人： MiMedx Group, Inc.
发明人： KOOB, Thomas J. , TOFE, Robert , CHEN, Elizabeth
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8.发明授权
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9.发明公开MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME 审中-公开微粒化胎盘组织组合物及其制备和使用方法
公开(公告)号：EP3311826A1
公开(公告)日：2018-04-25
申请号：EP17190524.3
申请日：2012-02-13
申请人： MiMedx Group, Inc.
发明人： MORSE, Brenda S. , SITH, Somaly , SPENCER, Randall , RAY, Steven , DANIEL, John , TOFE, Robert
CPC分类号： A61K35/50 , A61K8/982 , A61K35/12 , A61L27/3604 , A61L27/3683 , A61L27/3695 , A61L2400/06 , A61L2430/34 , A61P17/02 , A61Q19/00
摘要： Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
摘要翻译： 本文描述了由微粉化胎盘组分和其药物组合物组成的组合物。 该组合物具有许多医学应用。 本文还描述了制造和使用微粉化组合物的方法。
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