公开(公告)号：EP2884844A1

公开(公告)日：2015-06-24

申请号：EP13829807.0

申请日：2013-08-09

申请人： MIMEDX Group Inc.

发明人： DANIEL, John ,  SPENCER, Randall ,  SITH, Somaly

IPC分类号： A01N63/00 ,  A61K35/66

CPC分类号： A61K35/50 ,  A01N1/0284 ,  A61F2/02 ,  A61K9/0019 ,  A61K9/14 ,  A61K45/06 ,  A61K47/02 ,  A61L26/0057 ,  A61L27/36 ,  A61L29/005 ,  A61L31/005 ,  F26B21/004 ,  A61K2300/00

摘要： This invention relates generally to a dehydration device and methods for drying biological materials to produce dried biological materials having enhanced structural properties. More specifically, the invention relates to a dehydration device and related methods for drying biological tissue to produce enhanced tissue grafts.

公开(公告)号：EP2675465A2

公开(公告)日：2013-12-25

申请号：EP12746488.1

申请日：2012-02-13

申请人： MIMEDX Group Inc.

发明人： MORSE, Brenda, S. ,  SITH, Somaly ,  SPENCER, Randall ,  DANIEL, John

IPC分类号： A61K35/50

CPC分类号： A61L27/3891 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3687 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3878 ,  A61L27/3882 ,  A61L2400/18 ,  A61L2430/12 ,  A61L2430/16 ,  A61L2430/22 ,  A61L2430/32 ,  A61L2430/40

摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. Also described herein are methods for making and using the tissue grafts.

公开(公告)号：EP2675279A1

公开(公告)日：2013-12-25

申请号：EP12747175.3

申请日：2012-02-13

申请人： MIMEDX Group Inc.

发明人： MORSE, Brenda, S. ,  SITH, Somaly ,  SPENCER, Randall ,  DANIEL, John ,  TOFE, Robert

IPC分类号： A01N63/00

摘要： Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.

公开(公告)号：EP3146039A1

公开(公告)日：2017-03-29

申请号：EP15796851.2

申请日：2015-05-21

申请人： MiMedx Group, Inc.

发明人： SPENCER, Randall ,  SITH, Somaly

IPC分类号： C12N5/00

CPC分类号： A61K35/51 ,  A61K9/0019 ,  A61K35/50 ,  A61L27/36 ,  C12N5/0605 ,  C12N2509/10

摘要： The present invention provides compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste, suitable for delivery into the space adjacent the articular surface cartilage injured region of a subject. The micronized Wharton's jelly when employed at sufficient concentrations can be hydrated into a gel or paste and administered topically, or it can be injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized in accordance with the present invention.

摘要翻译： 本发明提供了具有受控粘度的微粉化沃顿顿果冻的组合物和制剂，使得当递送至受试者的受损区域时，其保持基本上定位，很少或没有迁移出受损区域用于其修复和/或再生。 微粉沃顿的果冻可以悬浮在药学上可接受的水性载体中，例如盐水，无菌水或任何合适的缓冲液，以形成悬浮液或凝胶状凝胶组合物，或者它可以是糊剂的形式，适于递送到 邻近被检体的关节面软骨损伤区域的空间。 微粉化的Wharton果冻以足够的浓度使用时，可以水合成凝胶或糊状物，并局部给药，也可以通过使用针头和注射器将其注入体内。 因此，麦芽糖的果冻，组合物或其制剂可以以比根据本发明未被微粉化的沃顿的果冻更方便的方式递送。

公开(公告)号：EP2585084A2

公开(公告)日：2013-05-01

申请号：EP12746721.5

申请日：2012-02-13

申请人： MIMEDX Group Inc.

发明人： MORSE, Brenda, S. ,  SITH, Somaly ,  SPENCER, Randall ,  RAY, Steven ,  DANIEL, John

IPC分类号： A61K35/50

CPC分类号： A61K35/50 ,  A61K8/982 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3695 ,  A61L2400/06 ,  A61L2430/34 ,  A61P17/02 ,  A61Q19/00

摘要： Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

公开(公告)号：EP3744336A1

公开(公告)日：2020-12-02

申请号：EP20171466.4

申请日：2012-02-13

申请人： MiMedx Group, Inc.

发明人： MORSE, Brenda S. ,  SITH, Somaly ,  SPENCER, Randall ,  RAY, Steven ,  DANIEL, John ,  TOFE, Robert

IPC分类号： A61K35/50 ,  A61L27/36 ,  A61Q19/00 ,  A61P17/02 ,  A61K8/98

摘要： Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

公开(公告)号：EP2675279B1

公开(公告)日：2020-06-24

申请号：EP12747175.3

申请日：2012-02-13

申请人： MIMEDX Group Inc.

发明人： MORSE, Brenda, S. ,  SITH, Somaly ,  SPENCER, Randall ,  DANIEL, John ,  TOFE, Robert

IPC分类号： A61L27/50 ,  A61F2/02 ,  A61L27/36 ,  A61K35/50

公开(公告)号：EP3311826A1

公开(公告)日：2018-04-25

申请号：EP17190524.3

申请日：2012-02-13

申请人： MiMedx Group, Inc.

发明人： MORSE, Brenda S. ,  SITH, Somaly ,  SPENCER, Randall ,  RAY, Steven ,  DANIEL, John ,  TOFE, Robert

IPC分类号： A61K35/50 ,  A61L27/36 ,  A61Q19/00 ,  A61P17/02 ,  A61K8/98

CPC分类号： A61K35/50 ,  A61K8/982 ,  A61K35/12 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3695 ,  A61L2400/06 ,  A61L2430/34 ,  A61P17/02 ,  A61Q19/00

摘要： Described herein are composition composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

摘要翻译： 本文描述了由微粉化胎盘组分和其药物组合物组成的组合物。 该组合物具有许多医学应用。 本文还描述了制造和使用微粉化组合物的方法。

公开(公告)号：EP3167049A1

公开(公告)日：2017-05-17

申请号：EP15819525.5

申请日：2015-07-07

申请人： MIMEDX Group Inc.

发明人： SPENCER, Randall ,  SITH, Somaly ,  KOOB, Thomas

IPC分类号： C12N5/073 ,  A61K35/50 ,  A61L27/38

CPC分类号： A61K35/51 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/16 ,  C12N5/065 ,  C12N2509/10

摘要： Provided are compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste and administered topically or injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized.

摘要翻译： 本发明提供具有控制粘度的微粉化沃顿粘胶的组合物和制剂，使得当递送到受试者的受伤部位时，其基本上保持局部化，很少或没有从受伤部位迁移出来用于其修复和/或再生。 微粉化的沃顿的果冻可以悬浮在药学上可接受的水性载体例如盐水，无菌水或任何合适的缓冲液中以形成悬浮液或凝胶状凝胶组合物，或者其可以呈糊状形式，适合于递送到 与受试者的关节面软骨损伤区域相邻的空间。 当以足够的浓度使用时，微粉化的沃顿果冻可以被水合成凝胶或糊状物并局部给药，或者可以通过使用针头和注射器将其注射到体内。 因此，可以按照比根据本发明未微粉化的沃顿胶冻更方便的方式来输送微粉化的沃顿胶冻，组合物或其制剂。