公开(公告)号：EP1373889A2

公开(公告)日：2004-01-02

申请号：EP01957383.1

申请日：2001-07-31

申请人： Maxygen, Inc.

发明人： MINSHULL, Jeremy ,  DAVIS, S., Christopher ,  WELCH, Mark ,  RAILLARD, Sun, Ai ,  VOGEL, Kurt ,  KREBBER, Claus

IPC分类号： G01N33/50

CPC分类号： C12N9/1252 ,  C12N15/1055 ,  C12P19/34 ,  C12Q1/6888

摘要： Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.

公开(公告)号：EP1276900A2

公开(公告)日：2003-01-22

申请号：EP01902036.1

申请日：2001-01-10

申请人： Maxygen, Inc.

发明人： BASS, Steven, H. ,  DAVIS, S., Christopher ,  PATTEN, Phillip, A. ,  TOBIN, Matthew ,  MINSHULL, Jeremy ,  WELCH, Mark ,  GUSTAFSSON, Claes ,  CARR, Brian ,  JENNE, Stephane ,  RAILLARD, Sun, Ai ,  CRAMERI, Andreas ,  STEMMER, Willem, P. C. ,  EMIG, Robin ,  LONGCHAMP, Pascal ,  GOLDMAN, Stanley ,  GIVER, Lorraine, J. ,  AFFHOLTER, Joseph A.

IPC分类号： C12Q1/68

CPC分类号： C12N15/1031 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/00722 ,  B82Y30/00 ,  C12N15/1027 ,  C40B60/04 ,  G06F19/18 ,  Y02A90/22

摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.

公开(公告)号：EP1287123B1

公开(公告)日：2011-03-02

申请号：EP01923084.6

申请日：2001-04-02

申请人： Maxygen, Inc. ,  Novozymes A/S

发明人： NESS, Jon, E. ,  WELCH, Mark ,  GIVER, Lorraine, J. ,  CHERRY, Joel, R. ,  BORCHERT, Torben, V. ,  STEMMER, Willem, P., C. ,  MINSHULL, Jeremy

IPC分类号： C12N9/54 ,  C12N15/57 ,  C07K16/40 ,  G06F17/50

CPC分类号： C12N9/6408 ,  C12N9/54

摘要： New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.

公开(公告)号：EP1287123A2

公开(公告)日：2003-03-05

申请号：EP01923084.6

申请日：2001-04-02

申请人： Maxygen, Inc. ,  Novozymes A/S

发明人： NESS, Jon, E. ,  WELCH, Mark ,  GIVER, Lorraine, J. ,  CHERRY, Joel, R. ,  BORCHERT, Torben, V. ,  STEMMER, Willem, P., C. ,  MINSHULL, Jeremy

IPC分类号： C12N9/54 ,  C12N15/57 ,  C07K16/40 ,  G06F17/50

CPC分类号： C12N9/6408 ,  C12N9/54

摘要： New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.

公开(公告)号：EP1072010B1

公开(公告)日：2010-04-21

申请号：EP00909923.5

申请日：2000-01-18

申请人： Maxygen, Inc.

发明人： CRAMERI, Andreas ,  STEMMER, Willem, P., C. ,  MINSHULL, Jeremy ,  BASS, Steven, H. ,  WELCH, Mark ,  NESS, Jon, E. ,  GUSTAFSSON, Claes ,  PATTEN, Phillip, A.

IPC分类号： G06F19/00

CPC分类号： C12N15/11 ,  B01J2219/00689 ,  C12N15/1031

摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.

公开(公告)号：EP1354031A2

公开(公告)日：2003-10-22

申请号：EP01957382.3

申请日：2001-07-31

申请人： Maxygen, Inc.

发明人： RAILLARD, Sun, Ai ,  WELCH, Mark ,  NESS, Jon

IPC分类号： C12N9/00

CPC分类号： C12N9/1252 ,  C12N15/1055 ,  C12P19/34 ,  C12Q1/6888

摘要： Nucleotide incorporating enzyme variants having improved properties including the ability to utilize non-natural or rare nucleotide analogues in the synthesis of polynucleotides are provided. Methods for producing such nucleotide incorporating enzyme variants are provided, as are kits and integrated systems including the nucleotide incorporating enzyme variants.

摘要翻译： 提供了具有改进性质的掺入核苷酸的酶变体，包括在合成多核苷酸中利用非天然或稀有核苷酸类似物的能力。 提供了产生这种结合核苷酸酶变体的方法，包括掺入核苷酸酶变体的试剂盒和整合系统。

公开(公告)号：EP1072010A2

公开(公告)日：2001-01-31

申请号：EP00909923.5

申请日：2000-01-18

申请人： Maxygen, Inc.

发明人： CRAMERI, Andreas ,  STEMMER, Willem, P., C. ,  MINSHULL, Jeremy ,  BASS, Steven, H. ,  WELCH, Mark ,  NESS, Jon, E. ,  GUSTAFSSON, Claes ,  PATTEN, Phillip, A.

IPC分类号： G06F19/00

CPC分类号： C12N15/11 ,  B01J2219/00689 ,  C12N15/1031

摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.