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公开(公告)号：EP0882016B1
公开(公告)日：2000-05-31
申请号：EP97900910.7
申请日：1997-01-29
发明人： BLACK, Cameron , GRIMM, Erich , HUGHES, Greg , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin
IPC分类号： C07C317/46 , C07C317/22 , C07C317/44 , C07C317/24 , C07D295/18 , A61K31/10
CPC分类号： C07D405/12 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07D307/58 , C07D307/60 , C07D307/64 , C07D307/66 , C07D307/94
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公开(公告)号：EP1163214A1
公开(公告)日：2001-12-19
申请号：EP00910448.0
申请日：2000-03-13
发明人： HAN, Yongxin , GRIMM, Erich , ASPIOTIS, Renee , FRANCOEUR, Sebastien , ZAMBONI, Robert , PRASIT, Petpiboon , BLACK, Cameron , GIROUX, Andre , BAYLY, Christopher , MCKAY, Daniel
IPC分类号： C07C323/59 , C07D239/34 , C07D271/06 , A61K31/198 , A61P25/00
CPC分类号： C07D239/34 , C07C323/59
摘要： Compounds represented by formula (I):as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.
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3.发明授权
公开(公告)号：EP0778834B1
公开(公告)日：2000-01-26
申请号：EP95928912.5
申请日：1995-08-24
IPC分类号： C07D333/54 , A61K31/38 , A61K31/44 , C07D307/79 , C07D209/10 , C07D333/56 , C07D495/04 , C07D493/04 , C07D491/04 , C07D409/04 , C07D413/04
CPC分类号： C07D307/79 , C07D209/10 , C07D333/18 , C07D495/04
摘要： The invention encompasses the novel compound of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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4.发明公开ALPHA-METHYLENE GAMMA LACTONES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS 失效ALPHA-METHYLEN GAMMA LACTONE ALS SELEKTIVE CYCLOOXYGENASE-2 HEMMER
公开(公告)号：EP0971910A1
公开(公告)日：2000-01-19
申请号：EP98913487.9
申请日：1998-03-31
发明人： LEGER, Serge , GRIMM, Erich , PRASIT, Petpiboon
IPC分类号： C07D307/58 , A61K31/34 , C07D405/06 , C07C317/24 , C07C317/14
CPC分类号： C07D405/06 , C07C317/14 , C07C317/24 , C07C2601/04 , C07C2601/08 , C07D307/58
摘要： The invention encompasses the novel compound of Formula (I) as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula (I).
摘要翻译： 本发明包括式（I）的新型化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无效治疗有效量的式（I）的化合物的患者施用。 本发明还包括用于治疗包含式（I）化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：EP0799218B1
公开(公告)日：2003-02-19
申请号：EP95941552.2
申请日：1995-12-18
发明人： BLACK, Cameron , GRIMM, Erich , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin
IPC分类号： C07D307/58 , C07D407/04 , C07D307/94 , C07C317/24 , C07F9/655 , C07F9/6553 , C07F9/6561 , A61K31/66
CPC分类号： C07D307/79 , C07C317/24 , C07D307/58 , C07D307/83 , C07D307/94 , C07D333/32 , C07D333/78 , C07D405/04 , C07D407/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D491/10 , C07D493/10 , C07D495/10 , C07F9/5325 , C07F9/65515
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公开(公告)号：EP0975604A1
公开(公告)日：2000-02-02
申请号：EP98910544.0
申请日：1998-03-12
IPC分类号： C07D237/04 , A61K31/50
CPC分类号： C07D401/04 , C07D237/14 , C07D237/16 , C07D401/12 , C07D409/06
摘要： The invention encompasses the pyridazin-3-one compounds of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).
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公开(公告)号：EP0975604B1
公开(公告)日：2004-07-21
申请号：EP98910544.0
申请日：1998-03-12
IPC分类号： C07D237/04 , A61K31/50
CPC分类号： C07D401/04 , C07D237/14 , C07D237/16 , C07D401/12 , C07D409/06
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公开(公告)号：EP1372655A2
公开(公告)日：2004-01-02
申请号：EP02723314.7
申请日：2002-03-01
发明人： PRASIT, Petpiboon , BAYLY, Christopher Ian , ROBICHAUD, Joel Stephane , BLACK, W. Cameron , SETTI, Eduardo, L. , RYDZEWSKI, Robert, M. , PALMER, James, T.
IPC分类号： A61K31/496 , A61P43/00 , C07D241/04
CPC分类号： C07D231/12 , C07C255/29 , C07C323/60 , C07C323/61 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D209/42 , C07D211/20 , C07D211/58 , C07D211/60 , C07D215/12 , C07D231/18 , C07D231/38 , C07D233/64 , C07D239/42 , C07D249/12 , C07D257/06 , C07D261/14 , C07D271/08 , C07D275/03 , C07D285/06 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/205 , C07D307/66 , C07D333/28 , C07D333/36 , C07D333/54 , C07D401/04 , C07D409/10 , C07D417/04 , C07D417/10 , C07D487/08
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指出骨吸收抑制的疾病，例如 骨质疏松症。
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9.发明授权
公开(公告)号：EP0863891B1
公开(公告)日：2002-12-11
申请号：EP96932417.7
申请日：1996-10-09
发明人： BELLEY, Michel , GAUTHIER, Jacques, Y. , GRIMM, Erich , LEBLANC, Yves , LI, Chung-Sing , THERIEN, Michel , BLACK, Cameron , LAU, Cheuk-Kun , PRASIT, Petpiboon , ROY, Patrick
IPC分类号： C07D307/58 , A61K31/365 , A61K31/38 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/94 , C07D213/64 , C07C317/24
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
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10.发明授权3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS 失效3,4-二芳基-2-羟基-2,5-二氢呋喃作为COX-2抑制剂的活性成分的前体
公开(公告)号：EP0904269B1
公开(公告)日：2002-01-23
申请号：EP96934267.4
申请日：1996-10-29
发明人： BLACK, Cameron , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin , HAMEL, Pierre , HAN, Yongxin , HUGHES, Gregory
IPC分类号： C07D307/32 , A61K31/34 , A61K31/44 , A61K31/18 , C07D307/30 , C07C317/22 , C07D213/30 , C07F9/117 , C07D307/94 , C07D405/12 , C07D417/12
CPC分类号： C07D307/32 , C07C317/22 , C07C323/64 , C07D213/34 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/94 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07F9/117
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