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公开(公告)号：EP3302484B1
公开(公告)日：2020-09-16
申请号：EP16804001.2
申请日：2016-05-24
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC: A61K31/519 , A61P25/28 , C07D487/04
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公开(公告)号：EP3394067B1
公开(公告)日：2020-04-01
申请号：EP16823455.7
申请日：2016-12-20
Applicant: Merck Sharp & Dohme Corp.
Inventor： BERGER, Raphelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKLE, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron, J. , STELMACH, John , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
IPC: C07D487/04 , C07D519/00 , A61K31/519 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04
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公开(公告)号：EP3154970B1
公开(公告)日：2019-11-06
申请号：EP15806980.7
申请日：2015-06-09
Applicant: Merck Sharp & Dohme Corp.
Inventor： WALJI, Abbas, M. , HOSTETLER, Eric , GRESHOCK, Thomas , LI, Jing , MOORE, Keith, P. , BENNACEF, Idriss , MULHEARN, James , SELNICK, Harold , WANG, Yaode , YANG, Kun , FU, Jianmin
IPC: C07D471/04
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4.发明授权
公开(公告)号：EP3233859B1
公开(公告)日：2019-08-07
申请号：EP15870726.5
申请日：2015-12-10
Applicant: Merck Sharp & Dohme Corp. , MSD R & D (China) Co. Ltd.
Inventor： SILIPHAIVANH, Phieng , SLOMAN, David L. , WITTER, David , MANSOOR, Umar Faruk , KOZLOWSKI, Joseph , LIU, Ziping , FU, Jianmin , WAN, Zhilong , LIU, Wei , QIAN, Yimin , HUANG, Xianhai
IPC: C07D471/04
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5.发明公开N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权N-（2-氰基 - 杂环基）吡唑并吡啶酮JANUSKINASEINHIBITOREN
公开(公告)号：EP2976338A1
公开(公告)日：2016-01-27
申请号：EP14767458.4
申请日：2014-03-19
Applicant: Merck Sharp & Dohme Corp.
Inventor： DINSMORE, Christopher , FULLER, Peter , GUERIN, David , THOMPSON, Christopher F. , PU, Qinglin , SCOTT, Mark E. , KATZ, Jason David , KURUKULASURIYA, Ravi , CLOSE, Joshua T. , FALCONE, Danielle , BRUBAKER, Jason , ZENG, Hongbo , BAI, Yunfeng , FU, Jianmin , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.
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Patent Agency Ranking6.发明公开3-TETRAZOLYL-BENZENE-1,2-DISULFONAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS 审中-公开作为金属β内酰胺酶抑制剂的3-四唑基 - 苯-1,2-二磺酰胺衍生物
公开(公告)号：EP3313832A1
公开(公告)日：2018-05-02
申请号：EP16734151.0
申请日：2016-06-24
Applicant: Merck Sharp & Dohme Corp.
Inventor： BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack, D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , YANG, Dexi , YOUNG, Katherine , XIAO, Li , ZHANG, Zhibo , FU, Jianmin
IPC: C07D403/12 , C07D413/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D407/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/04 , A61K31/41 , A61K31/4184 , A61K31/428 , A61K31/4439 , A61P31/04
CPC classification number: C07D403/10 , A61K31/198 , A61K31/407 , A61K31/41 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/431 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/546 , A61K45/06 , A61P31/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/10 , C07D493/04 , C07D493/08 , C07D495/08
Abstract: The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X 2 and R1are as defined herein. The present invention also relates to compositions which comprise a metallo-beta-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
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7.发明授权N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权N-（2-氰基杂环基）吡唑并吡啶作为JANUS激酶抑制剂
公开(公告)号：EP2976338B1
公开(公告)日：2018-01-03
申请号：EP14767458.4
申请日：2014-03-19
Applicant: Merck Sharp & Dohme Corp.
Inventor： DINSMORE, Christopher , FULLER, Peter , GUERIN, David , THOMPSON, Christopher F. , PU, Qinglin , SCOTT, Mark E. , KATZ, Jason David , KURUKLASURIYA, Ravi , CLOSE, Joshua T. , FALCONE, Danielle , BRUBAKER, Jason , ZENG, Hongbo , BAI, Yunfeng , FU, Jianmin , KONG, Norman , LIU, Yumei , ZHENG, Zhixiang
IPC: C07D471/04 , A61K31/437 , A61P35/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.
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8.发明公开4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS 审中-公开作为HIV逆转录酶抑制剂的4'-取代的核苷衍生物
公开(公告)号：EP3122752A1
公开(公告)日：2017-02-01
申请号：EP15715934.4
申请日：2015-03-26
Applicant: Merck Sharp & Dohme Corp.
Inventor： GIRIJAVALLABHAN, Vinay, M. , OLSEN, David, B. , ZHANG, Zhibo , FU, Jianmin , TANG, Bing-Yu
IPC: C07D487/04 , C07H19/06 , C07H19/14 , A61K31/7064 , A61K31/7076 , A61P1/16
CPC classification number: C07H19/14 , A61K31/7064 , A61K45/06 , C07D487/04 , C07H19/06 , C07H19/12
Abstract: The present invention is directed to 4′-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
Abstract translation: 本发明涉及式I的4'-取代的核苷衍生物及其在抑制HIV逆转录酶，预防HIV感染，治疗HIV感染以及预防，治疗和延缓 艾滋病和/或ARC的发病或进展。
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公开(公告)号：EP3233858B1
公开(公告)日：2019-10-30
申请号：EP15870725.7
申请日：2015-12-10
Applicant: Merck Sharp & Dohme Corp.
Inventor： SILIPHAIVANH, Phieng , METHOT, Joey , LIPFORD, Kathryn Ann , MOLINARI, Danielle , SLOMAN, David, L. , WITTER, David , ZHOU, Hua , BOYCE, Christopher , HUANG, Xianhai , LIM, Jongwon , GUERIN, David , KARUNAKARAN, Ganesh Babu , BAKSHI, Raman Kumar , LIU, Ziping , FU, Jianmin , WAN, Zhilong , LIU, Wei
IPC: C07D471/04
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公开(公告)号：EP3154976B1
公开(公告)日：2019-07-24
申请号：EP15819372.2
申请日：2015-06-09
Applicant: Merck Sharp & Dohme Corp.
Inventor： MCGOWAN, Meredeth Ann , FONG, Kin Chiu , ANTHONY, Neville John , ZHOU, Hua , KATZ, Jason D. , YANG, Lihu , LI, Chaomin , TIAN, Yuan , MU, Changwei , YE, Baijun , SHI, Feng , ZHAO, Xiaoli , FU, Jianmin , LI, Yabin
IPC: C07D473/34 , C07D473/30 , A61K31/52 , A61P19/02 , A61P11/00 , A61P37/00 , A61P35/00 , C07D519/00
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