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1.发明公开
公开(公告)号：EP3302484A1
公开(公告)日：2018-04-11
申请号：EP16804001.2
申请日：2016-05-24
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC: A61K31/519 , A61P25/28 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28
Abstract: The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：EP3302486A1
公开(公告)日：2018-04-11
申请号：EP16804194.5
申请日：2016-05-31
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： SHEN, Dong-Ming , DWYER, Michael P. , SINZ, Christopher J. , WANG, Deping , STACHEL, Shawn , PAONE, Daniel V. , FORSTER, Ashley , BERGER, Richard , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei
IPC: A61K31/519 , A61P25/28 , C07D487/04
Abstract: The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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3.发明公开
公开(公告)号：EP3087060A1
公开(公告)日：2016-11-02
申请号：EP14873215.9
申请日：2014-12-17
Applicant: Merck Sharp & Dohme Corp. , MSD R & D (China) Co. Ltd.
Inventor： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC: C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
CPC classification number: C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
Abstract: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
Abstract translation: 公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。
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公开(公告)号：EP3302486B1
公开(公告)日：2020-09-30
申请号：EP16804194.5
申请日：2016-05-31
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： SHEN, Dong-Ming , DWYER, Michael P. , SINZ, Christopher J. , WANG, Deping , STACHEL, Shawn , PAONE, Daniel V. , FORSTER, Ashley , BERGER, Richard , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei
IPC: A61K31/519 , A61P25/28 , C07D487/04
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公开(公告)号：EP3302484B1
公开(公告)日：2020-09-16
申请号：EP16804001.2
申请日：2016-05-24
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC: A61K31/519 , A61P25/28 , C07D487/04
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Patent Agency Ranking
公开(公告)号：EP3087060B1
公开(公告)日：2020-05-13
申请号：EP14873215.9
申请日：2014-12-17
Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC: C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
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7.发明公开
公开(公告)号：EP3027593A2
公开(公告)日：2016-06-08
申请号：EP14832049.2
申请日：2014-07-29
Applicant: Merck Sharp & Dohme Corp. , MSD R & D (China) Co. Ltd.
Inventor： WILLIAMS, Peter D. , MCCAULEY, John A. , BENNETT, David J. , BUNGARD, Christopher J. , CHANG, Lehua , CHU, Xin-Jie , DWYER, Michael P. , HOLLOWAY, M. Katherine , KEERTIKAR, Kartik M. , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , MORRIELLO, Gregori J. , SHEN, Dong-Ming , SHERER, Edward C. , SCHULZ, Jurgen , WADDELL, Sherman Tim , WISCOUNT, Catherine M. , ZORN, Nicolas , SATYANARAYANA, Tummanapalli , VIJAYASARADHI, Sivalenka , HU, Bin , JI, Tao , ZHONG, Bin
IPC: C07D295/088
CPC classification number: C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
Abstract translation: 本发明涉及哌嗪衍生物，包含它们的药物组合物及其在抑制HIV蛋白酶中的用途，HIV复制的抑制，HIV预防感染，HIV感染治疗以及预防，治疗 ，并延迟艾滋病的发病或进展。
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公开(公告)号：EP3291817B1
公开(公告)日：2019-10-02
申请号：EP16789873.3
申请日：2016-05-02
Applicant: Merck Sharp & Dohme Corp.
Inventor： SHEN, Dong-Ming , WILSON, Jonathan, E. , MCCRACKEN, Troy
IPC: A61K31/513 , C07D403/04 , C07D239/36
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公开(公告)号：EP2568812A1
公开(公告)日：2013-03-20
申请号：EP11781053.1
申请日：2011-05-06
Applicant: Merck Sharp & Dohme Corp.
Inventor： HALE, Jeffrey, J. , JIANG, Jinlong , SHEN, Dong-Ming , SHI, Zhi-Cai , SHU, Min , WU, Zhicai , YANG, Cangming
IPC: A01N43/56 , A61K31/415
CPC classification number: C07D401/04 , C07D401/14
Abstract: Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
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公开(公告)号：EP2470021A1
公开(公告)日：2012-07-04
申请号：EP10812498.3
申请日：2010-08-17
Applicant: Merck Sharp & Dohme Corp.
Inventor： EDMONDSON, Scott, D. , BERGER, Richard , CHANG, Lehua , COLANDREA, Vincent, J. , HALE, Jeffrey, J. , HARPER, Bart , KAR, Nam Fung , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Christopher, R. , SHA, Deyou , SHEN, Dong-Ming , WANG, Liping , WENDT, Harvey, R. , ZHU, Cheng
CPC classification number: C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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