公开(公告)号：EP2404997A1

公开(公告)日：2012-01-11

申请号：EP10748842.1

申请日：2010-03-05

申请人： Mie University ,  TAKARA BIO INC.

发明人： SHIKU, Hiroshi ,  IKEDA, Hiroaki ,  IWAMURA, Koichi ,  MINENO, Junichi ,  KATO, Ikunoshin

IPC分类号： C12N15/00 ,  A61K35/14 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C12N5/10 ,  C12N15/09 ,  A61K31/713 ,  A61K48/00

CPC分类号： A61K35/17 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N15/113 ,  C12N2310/14 ,  C12N2501/48 ,  C12N2501/599 ,  C12N2310/531

摘要： Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.

公开(公告)号：EP2172547A1

公开(公告)日：2010-04-07

申请号：EP08777135.8

申请日：2008-06-10

申请人： Takara Bio, Inc. ,  Mie University

发明人： MINENO, Junichi ,  OKAMOTO, Sachiko ,  SUMIOKA, Risa ,  KITAGAWA, Masanari ,  SHIKU, Hiroshi ,  KATO, Ikunoshin

IPC分类号： C12N15/09 ,  C12N5/10

CPC分类号： C07K14/7051 ,  C12N15/85 ,  C12N2800/40 ,  C12N2840/102

摘要： Disclosed is a cell which can express a non-natural oligomeric protein, which has, introduced therein, a gene encoding an exogenous polypeptide corresponding to at least one endogenous polypeptide constituting a natural oligomeric protein, and in which the expression of the endogenous polypeptide is inhibited.

摘要翻译： 公开了一种可以表达非天然低聚蛋白的细胞，其中引入了编码对应于至少一种构成天然低聚蛋白的内源多肽的外源多肽的基因，并且其中内源多肽的表达被抑制 。

公开(公告)号：EP2765193A1

公开(公告)日：2014-08-13

申请号：EP12838701.6

申请日：2012-10-05

申请人： Mie University ,  Takara Bio, Inc.

发明人： SHIKU, Hiroshi ,  ORITO, Yuki ,  MINENO, Junichi ,  OKAMOTO, Sachiko ,  AMAISHI, Yasunori

IPC分类号： C12N15/09 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10

CPC分类号： C12N15/85 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/30 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/30

摘要： Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.

公开(公告)号：EP2404997B1

公开(公告)日：2017-10-18

申请号：EP10748842.1

申请日：2010-03-05

申请人： Mie University ,  TAKARA BIO INC.

发明人： SHIKU, Hiroshi ,  IKEDA, Hiroaki ,  IWAMURA, Koichi ,  MINENO, Junichi ,  KATO, Ikunoshin

IPC分类号： C12N15/00 ,  A61K35/14 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C12N5/10 ,  C12N15/09 ,  A61K31/713 ,  A61K48/00 ,  C12N5/0783 ,  C12N15/113 ,  A61K35/12 ,  A61K35/17 ,  A61K39/00

CPC分类号： A61K35/17 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N15/113 ,  C12N2310/14 ,  C12N2501/48 ,  C12N2501/599 ,  C12N2310/531

摘要： Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.

公开(公告)号：EP2765193B1

公开(公告)日：2017-08-09

申请号：EP12838701.6

申请日：2012-10-05

申请人： Mie University ,  Takara Bio Inc.

发明人： SHIKU, Hiroshi ,  ORITO, Yuki ,  MINENO, Junichi ,  OKAMOTO, Sachiko ,  AMAISHI, Yasunori

IPC分类号： C12N15/09 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10

CPC分类号： C12N15/85 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/30 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/30

公开(公告)号：EP2172547B1

公开(公告)日：2016-01-06

申请号：EP08777135.8

申请日：2008-06-10

申请人： Takara Bio Inc. ,  Mie University

发明人： MINENO, Junichi ,  OKAMOTO, Sachiko ,  SUMIOKA, Risa ,  KITAGAWA, Masanari ,  SHIKU, Hiroshi ,  KATO, Ikunoshin

IPC分类号： C12N15/09 ,  C12N5/10

CPC分类号： C07K14/7051 ,  C12N15/85 ,  C12N2800/40 ,  C12N2840/102

公开(公告)号：EP2612909A1

公开(公告)日：2013-07-10

申请号：EP11830659.6

申请日：2011-10-04

申请人： Takara Bio, Inc.

发明人： SHINMURA, Kazuhisa ,  KATAYAMA, Yoshinori ,  SAKAI, Kensuke ,  SHODAI, Toshihiro ,  YOSHIOKA, Hirofumi ,  MINENO, Junichi

IPC分类号： C12N5/10 ,  C12N7/02 ,  C12N15/867

CPC分类号： C12N15/64 ,  C12N7/00 ,  C12N2500/36 ,  C12N2501/065 ,  C12N2501/39 ,  C12N2740/10051

摘要： The present invention provides a method for producing a virus vector, which comprises a step wherein cells that are capable of producing a virus vector are cultured in a culture medium that contains, as active components, a retinoic acid and a histone deacetylase inhibiting substance; and a culture medium for the production of a virus vector, which is characterized by containing, as active components, a retinoic acid and a histone deacetylase inhibiting substance.

摘要翻译： 本发明提供一种病毒载体的制造方法，其特征在于，包括：在含有视黄酸和组蛋白脱乙酰酶抑制物质作为有效成分的培养基中培养能够产生病毒载体的细胞的步骤; 以及用于生产病毒载体的培养基，其特征在于含有视黄酸和组蛋白脱乙酰酶抑制物质作为活性成分。

公开(公告)号：EP1304377B1

公开(公告)日：2008-10-22

申请号：EP01984244.2

申请日：2001-07-18

申请人： TAKARA BIO INC.

发明人： TSUBOSA, Yasuhiro ,  AOYAGI, Kazuhiko ,  SASAKI, Hiroki ,  TERADA, Masaaki ,  MINENO, Junichi ,  ASADA, Kiyozo ,  KATO, Ikunoshin

IPC分类号： C12N15/12 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/158

摘要： A method of selecting a marker gene which is useful in identifying cancer; a method of identifying cancer by using this gene; a method of detecting cancer, a kit to be used in the identification or detection method; and a DNA array holding the above gene. Thus, it is possible to obtain a gene which shows a change in the expression dose independently from a gene showing a change in the expression specifically at the proliferation of cells and specifically to each cancer sample. Use of this gene makes it possible to conveniently and quickly identify or detect cancer withou resort to any surgical operations, thereby contributing to the diagnonis and treatment of cancer, etc.

公开(公告)号：EP1921136A1

公开(公告)日：2008-05-14

申请号：EP06796333.0

申请日：2006-08-10

申请人： Takara Bio, Inc.

发明人： CHONO, Hideto ,  MATSUMOTO, Kazuya ,  MINENO, Junichi ,  KATO, Ikunoshin

IPC分类号： C12N15/00 ,  A61K31/7088 ,  A61K35/76 ,  A61K48/00 ,  A61P31/18 ,  A61P43/00 ,  C12N5/10 ,  C12N15/09

CPC分类号： C12N15/86 ,  A61K31/7088 ,  A61K35/17 ,  A61K38/00 ,  A61K38/465 ,  A61K48/00 ,  C07K14/4702 ,  C12N5/0636 ,  C12N9/22 ,  C12N15/85 ,  C12N2510/00 ,  C12N2830/002 ,  Y02A50/473

摘要： A nucleic acid comprising a transcription regulation sequence whose transcription is induced by a trans-acting factor of a human immunodeficiency virus and a gene encoding a polypeptide having an endoribonuclease activity specific to single-stranded RNA, wherein the gene is located in such a position that the expression of the gene can be regulated by the transcription regulation sequence; a method for production of a cell showing an inhibited replication of a human immunodeficiency virus therein, the method comprising the step of introducing the nucleic acid into a cell; and a method for treatment or prevention of a human immunodeficiency virus infection.

摘要翻译： 一种核酸，其包含转录调控序列，其转录由人免疫缺陷病毒的反式作用因子和编码具有对单链RNA特异性的内切核糖核酸酶活性的多肽的基因所诱导，其中所述基因位于 该基因的表达可以通过转录调节序列调节; 一种在其中显示抑制人体免疫缺陷病毒复制的细胞的制备方法，所述方法包括将核酸引入细胞的步骤; 以及用于治疗或预防人类免疫缺陷病毒感染的方法。

公开(公告)号：EP1329516A1

公开(公告)日：2003-07-23

申请号：EP01974664.3

申请日：2001-10-03

申请人： TAKARA BIO INC.

发明人： ENOKI, Tatsuji ,  YAMASHITA, Shusaku ,  ROKUSHIMA, Masatomo ,  MINENO, Junichi ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

IPC分类号： C12Q1/68 ,  C12N15/09 ,  C12M1/00 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  A61K31/351 ,  A61K45/00

CPC分类号： G01N33/5088 ,  G01N2500/00

摘要： The present invention provides a method of screening a biologically active substance or a candidate substance for a biologically active substance, possessing an activity for controlling gene expression to the same extent to that of DGE; a gene controlling agent which is effective for maintaining homeostasis in a living body, for instance, purposed for mitigation or prevention of stress; and a method of controlling a gene.

摘要翻译： 本发明提供筛选生物活性物质或生物活性物质候选物质的方法，其具有与DGE相同程度的控制基因表达的活性; 用于维持活体内的体内平衡有效的基因控制剂，例如减轻或预防应激的基因控制剂; 和控制基因的方法。