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公开(公告)号：EP1157694A4
公开(公告)日：2002-08-28
申请号：EP99973258
申请日：1999-11-30
发明人： TANIKAWA KEIZO , TSURUZOE NOBUTOMO , SHUDO NORIMASA , YAMASHITA TORU , ISHIWATA NORIHISA , KIDO HIDEAKI , EBISU HAJIME , HAYASHI KAZUTAKA , KUBO YOSHIJI , NAKAMURA NORIFUMI
IPC分类号： A61K31/50 , A61K31/501 , A61P15/10
CPC分类号： A61K31/501 , A61K31/50
摘要： An erectile dysfunction remedy which comprises as the active ingredient a 3(2H)-pyridazinone derivative represented by formula (I) or a pharmacologically acceptable salt thereof, wherein the symbols each is the same as defined in the description.
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公开(公告)号：EP1845090A4
公开(公告)日：2009-11-11
申请号：EP05819752
申请日：2005-12-14
发明人： MIYAJI KATSUAKI , IWAMOTO SHUNSUKE , NAKANO SATOSHI , OTA HIROFUMI , SHIGETA YUKIHIRO , HIROKAWA YUTAKA , YANAGIHARA K , TOYAMA KOJI , HORIKAWA M , ISHIWATA NORIHISA , OWADA SHINGO
IPC分类号： C07D231/18 , A61K31/381 , A61K31/4025 , A61K31/415 , A61K31/4155 , A61K31/4436 , A61K31/4535 , A61K31/5377 , A61P7/04 , A61P43/00 , C07D333/32 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D231/18
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3.发明公开METHOD FOR AMPLIFICATION OF HEMATOPOIETIC STEM CELL USING HETEROCYCLIC COMPOUND 审中-公开含杂环化合物的造血干细胞扩增方法
公开(公告)号：EP2228435A4
公开(公告)日：2013-01-23
申请号：EP08858273
申请日：2008-12-05
CPC分类号： C12N5/0647 , A61K2035/124 , C07D231/12 , C07D333/22 , C07D409/12 , C07D409/14 , C07D417/14 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
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4.发明公开
公开(公告)号：EP2228434A4
公开(公告)日：2013-01-23
申请号：EP08857879
申请日：2008-12-05
CPC分类号： C12N5/0647 , A61K2035/124 , C07D231/12 , C07D333/22 , C07D409/12 , C07D409/14 , C07D417/14 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound, or a solvate thereof.
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公开(公告)号：EP1947101A4
公开(公告)日：2009-09-16
申请号：EP06823097
申请日：2006-11-07
IPC分类号： C07D409/12 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P7/00 , A61P9/00 , A61P9/10 , A61P43/00 , C07D409/14
CPC分类号： C07D409/12 , C07D409/14
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公开(公告)号：EP1552828A4
公开(公告)日：2007-01-24
申请号：EP03788115
申请日：2003-08-14
发明人： MIYAJI KATSUAKI , ISHIWATA NORIHISA , NAKAMURA TAKANORI , NISHINO TAITO , KAMIYA HISAO , YAMAMOTO MASAO
IPC分类号： A61K31/277 , A61K31/4402 , A61K31/4409 , A61K31/4453 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/08 , A61P9/10 , A61P43/00 , C07C255/37
CPC分类号： A61K31/4409 , A61K31/277 , A61K31/4402 , A61K31/4453 , C07C255/37
摘要： A medicine for the prevention of, treatments for, and alleviation of diseases in which thrombopoetin receptor activation is effective. It is a thrombopoetin receptor activator represented by the formula (1): (1) wherein R and R each independently means hydrogen, SO3H, C1-6 alkyl, C1-6 alkylcarbonyl, or C6-18 arylcarbonyl (the C1-6 alkyl, C1-6 alkylcarbonyl, and C6-18 arylcarbonyl may be optionally substituted by halogeno, hydroxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C6-18 aryl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, or NR R ); and R , R , and R each independently means hydrogen, hydroxy, or C1-6 alkoxy.
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7.发明公开METHOD FOR AMPLIFICATION OF HEMATOPOIETIC STEM CELL USING HETEROCYCLIC COMPOUND 审中-公开用于扩增造血干细胞方法的杂环化合物的方法
公开(公告)号：EP2233561A4
公开(公告)日：2013-01-16
申请号：EP08856980
申请日：2008-12-05
CPC分类号： C12N5/0647 , A61K35/12 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 本发明的目的是扩大的CD34 +细胞体外有效地使用生物安全且廉价地获得的低分子量化合物短期。 本发明的无声anOtherObject是提供扩张剂用于治疗由不正常的造血干细胞和/或造血祖细胞引起的各种造血病症CD34 +细胞。 一种用于扩展CD34 +细胞的方法，该方法包括培养的CD34 +细胞体外（在化合物的由式（I）表示的存在其中A，B，L 1，L 2，L 3，L 4，R 1， R 2，R 3，X和Y在说明书中定义），该化合物或其溶剂化物的互变异构体或药学上可接受的盐。
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8.发明公开
公开(公告)号：EP2218716A4
公开(公告)日：2012-07-25
申请号：EP08858085
申请日：2008-12-06
发明人： NISHINO TAITO , ISHIWATA NORIHISA , MIYAJI KATSUAKI , IWAMOTO SHUNSUKE , ASAI YASUYUKI , YUI MAKIKO
IPC分类号： C07D333/38 , A61K31/381 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/4436 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K35/14 , A61K35/18 , A61K38/00 , A61K38/22 , A61K48/00 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/10 , A61P35/00
CPC分类号： C07D333/38 , A61K35/00 , C07D409/14 , C07D413/14 , C07D417/14 , C12N5/0647 , C12N2501/999
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9.发明公开NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR 审中-公开含氮杂环化合物及THROMBOPOIETINREZEPTORAKTIVATOR
公开(公告)号：EP2025671A4
公开(公告)日：2011-04-06
申请号：EP07744900
申请日：2007-06-07
发明人： MIYAJI KATSUAKI , IWAMOTO SHUNSUKE , SHIGETA YUKIHIRO , HIROKAWA YUTAKA , OOWADA SHINGO , NAKAMURA TAKANORI , ISHIWATA NORIHISA
IPC分类号： C07D231/22 , A61K31/454 , A61K31/496 , A61P7/00 , A61P7/04 , A61P9/00 , A61P9/10 , A61P43/00 , C07D401/12 , C07D403/12
CPC分类号： C07D231/22 , C07D401/12 , C07D403/12
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