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公开(公告)号：EP0722459B1
公开(公告)日：1998-12-23
申请号：EP94920544.7
申请日：1994-07-11
发明人： AGNER, Erik , CUTHBERTSON, Alan , FISCHER, Peter , BHATNAGAR, Pradip , HUSBYN, Mette , UNDHEIM, Kjell
摘要： The invention relates to peptide compounds comprising two monomeric peptides having cell proliferation regulatory activity joined together by two or more divalent bridging units. Such compounds have a stimulating activity on cell division, especially for myelopoietic and bone marrow cells.
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公开(公告)号：EP0971747A2
公开(公告)日：2000-01-19
申请号：EP97910516.0
申请日：1997-10-28
CPC分类号： A61K49/0056 , A61K49/0021 , A61K49/0043 , A61K49/0052 , A61K49/0091 , A61K49/10 , A61K49/103 , A61K49/223 , A61K51/04 , A61K51/0453 , A61K51/0478 , A61K51/0497 , A61K51/1255
摘要： The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotension or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g. 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.
摘要翻译： 本发明提供式（I）的物质组合物：VLR，其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是接头部分或键，并且R是在体内成像中可检测的部分 条件是当V是血管紧张素或肽类血管紧张素衍生物或类似物时，则VLR不是非金属放射性核素取代的肽（例如125 I取代的血管紧张素II）而LV不是简单的肽，而是 与其侧链结合的螯合剂酰胺。 这种物质组合物可以用于成像心血管疾病和病症。
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3.发明公开PYRIDINE AND PYRAZINEDICARBOXYLIC-ACID DERIVATIVES AS CELL PROLIFERATION REGULATORS 失效吡啶和PYRAZINDICARBONSÄUREDERIVATE细胞生长调节剂
公开(公告)号：EP0799208A1
公开(公告)日：1997-10-08
申请号：EP95941202.0
申请日：1995-12-20
发明人： SANDOSHAM, Jessie , HIEBL, Johann , KOLLMANN, Hermann , CUTHBERTSON, Alan , FISCHER, Peter , HARTMANN, Michael , KREMMINGER, Peter , ROVENSZKY, Franz , HUSBYN, Mette
CPC分类号： C07D213/82 , C07D241/24 , C07D487/04
摘要： The present invention relates to pyridine and pyrazine-containing compounds capable of regulating, in particular stimulating, haematopoiesis.
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4.发明授权PYRIDINE AND PYRAZINEDICARBOXYLIC-ACID DERIVATIVES AS CELL PROLIFERATION REGULATORS 失效吡啶和PYRAZINDICARBONSÄUREDERIVATE细胞生长调节剂
公开(公告)号：EP0799208B1
公开(公告)日：2000-09-13
申请号：EP95941202.4
申请日：1995-12-20
申请人： NYCOMED IMAGING AS
发明人： SANDOSHAM, Jessie , HIEBL, Johann , KOLLMANN, Hermann , CUTHBERTSON, Alan , FISCHER, Peter , HARTMANN, Michael , KREMMINGER, Peter , ROVENSZKY, Franz , HUSBYN, Mette
IPC分类号： C07D213/81 , C07D241/24 , A61K31/44 , A61K31/495
CPC分类号： C07D213/82 , C07D241/24 , C07D487/04
摘要： The present invention relates to pyridine and pyrazine-containing compounds capable of regulating, in particular stimulating, haematopoiesis.
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公开(公告)号：EP0963209A2
公开(公告)日：1999-12-15
申请号：EP97910518.0
申请日：1997-10-28
发明人： KLAVENESS, Jo , RONGVED, P l , H GSET, Anders , TOLLESHAUG, Helge , GODAL, Aslak , CUTHBERTSON, Alan , L VHAUG, Dagfinn , SOLBAKKEN, Magne
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0091 , A61K49/223 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generated material, in which the reporter is coupled or linked to one or more non-bioactive vectors.
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公开(公告)号：EP0946202A2
公开(公告)日：1999-10-06
申请号：EP97910517.0
申请日：1997-10-28
CPC分类号： A61K49/0052 , A61K47/542 , A61K47/6925 , A61K49/10 , A61K49/101 , A61K49/223 , A61K51/04 , A61K51/0497 , A61K51/1255
摘要： The invention provides a composition of matter of the formula (I): V - L - R where V is a non-peptidic organic group having binding affinity for an endothelin receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body. This composition of matter may be used to image diseases and disorders, particularly of the cardiovascular system.
摘要翻译： 本发明提供了式（I）物质的组合物：其中V是对于内皮素受体位点具有结合亲和力的非肽有机基团，L是接头部分或键，并且R是 在人体或动物体的体内成像中可检测到的部分。 这种物质组合物可以用于成像疾病和病症，特别是心血管系统。
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公开(公告)号：EP0722459A1
公开(公告)日：1996-07-24
申请号：EP94920544.0
申请日：1994-07-11
发明人： AGNER, Erik , CUTHBERTSON, Alan , FISCHER, Peter , BHATNAGAR, Pradip , HUSBYN, Mette , UNDHEIM, Kjell
摘要： The invention relates to peptide compounds comprising two monomeric peptides having cell proliferation regulatory activity joined together by two or more divalent bridging units. Such compounds have a stimulating activity on cell division, especially for myelopoietic and bone marrow cells.
摘要翻译： 本发明涉及包含两种单体肽的肽化合物，所述单体肽具有通过两个或更多个二价桥连单位连接在一起的细胞增殖调节活性。 这些化合物对细胞分裂具有刺激活性，特别是对于骨髓生成和骨髓细胞。
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