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公开(公告)号：EP1620107A1
公开(公告)日：2006-02-01
申请号：EP04760339.4
申请日：2004-04-23
申请人： Novacardia, Inc.
IPC分类号： A61K31/522 , A61K31/635 , A61K31/63 , A61P7/10
CPC分类号： A61K45/06 , A61K31/405 , A61K31/522 , A61K31/63 , A61K31/635 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.
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2.发明公开PROLONGED IMPROVEMENT OF RENAL FUNCTION COMPRISING INFREQUENT ADMINISTRATION OF AN AA1RA 审中-公开WITH A AA 1 RA珍稀行政肾功能的永久改进
公开(公告)号：EP2035009A1
公开(公告)日：2009-03-18
申请号：EP07796202.5
申请日：2007-06-14
申请人： Novacardia, Inc.
发明人： DITTRICH, Howard , FARMER, Brian , WOODS, Randy
IPC分类号： A61K31/522 , A61P9/04 , A61P13/12
CPC分类号： A61K31/522
摘要： A method for treating a patient, comprising providing a therapeutically-effective amount of an AA1RA to the patient; and informing the patient or a medical care worker that administration of the AA1RA can provide an improvement in renal function that persists for a time period following administration of the AA1RA, and wherein the time period is at least 3 days.
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公开(公告)号：EP2061793A2
公开(公告)日：2009-05-27
申请号：EP07811385.9
申请日：2007-08-17
申请人： Novacardia, Inc.
IPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10 , C07D473/12 , C07D473/14 , C07D473/20 , C07D473/22 , A61K31/522 , A61K31/52 , A61P11/08 , A61P7/10
CPC分类号： C07D473/04 , C07D473/06
摘要： The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing KW-3902 derivatives of Formula (I), (II), (HI), (IV), (V), and (VI).
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4.发明公开CO-ADMINISTRATION OF ADENOSINE A1 RECEPTOR ANTAGONISTS AND ANTICONVULSANTS 审中-公开A1腺苷受体拮抗剂和抗惊厥药的联合管理
公开(公告)号：EP2001479A2
公开(公告)日：2008-12-17
申请号：EP07754928.5
申请日：2007-04-04
申请人： Novacardia, Inc.
发明人： DITTRICH, Howard , WEBER, Eckard , FARMER, Brian
IPC分类号： A61K31/52 , A61K31/5513 , A61K31/635 , A61P13/02
CPC分类号： A61K31/5513 , A61K31/19 , A61K31/195 , A61K31/515 , A61K31/52 , A61K31/522 , A61K31/55 , A61K31/635 , A61K31/7008 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions that include an AA1RA, or a salt, ester, amide, metabolite, or prodrug thereof, and an anticonvulsant agent. Also disclosed are methods of treating patients suffering from congestive heart failure, methods of improving renal function, and methods of restoring renal function comprising the step of administering a therapeutically effective amount of an AA1RA or a salt, ester, amide, metabolite, or prodrug thereof, in combination with an anticonvulsant agent.
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5.发明公开USE OF KW-3902 FOR ACHIEVING DIURESIS IN PATIENTS WITH CONGESTIVE HEART FAILURE AND ACUTE FLUID OVERLOAD 审中-公开KW-3902的使用能达到排尿在与心脏衰竭和急性积液患者充血
公开(公告)号：EP2035092A2
公开(公告)日：2009-03-18
申请号：EP07796072.2
申请日：2007-06-12
申请人： Novacardia, Inc.
发明人： DITTRICH, Howard , FARMER, Brian , WOODS, Randy
IPC分类号： A61P7/10 , A61K31/4985 , A61K31/635 , A61K45/06
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/635
摘要： Methods of treating patients with acute fluid overload comprising administering diuretic therapy and an amount of KW-3902, a pharmaceutically acceptable salt, ester, amide, metabolite, or prodrug thereof, effective to accelerate removal of excess fluid from the patient in comparison to diuretic therapy alone. Methods of improving the treatment time to achieve adequate diuresis in an individual experiencing acute fluid overload comprising administering to said individual a diuretic and a therapeutically effective amount of KW-3902 or a pharmaceutically acceptable salt, ester, amide, metabolite, or prodrug thereof.
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6.发明公开METHOD OF IMPROVED DIURESIS IN INDIVIDUALS WITH IMPAIRED RENAL FUNCTION 审中-公开于改善排尿方法对于患有impairers肾功能
公开(公告)号：EP2034992A2
公开(公告)日：2009-03-18
申请号：EP07796074.8
申请日：2007-06-12
申请人： Novacardia, Inc.
发明人： DITTRICH, Howard , FARMER, Brian , WOODS, Randy
IPC分类号： A61K31/405 , A61K31/522 , A61K31/635 , A61K45/06 , A61P13/12
CPC分类号： A61K45/06 , A61K31/405 , A61K31/522 , A61K31/635 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.
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