公开(公告)号：EP4427590A2

公开(公告)日：2024-09-11

申请号：EP24176079.2

申请日：2022-04-15

申请人： Novartis AG

发明人： FAN, Liqiong ,  HAINZL, Dominik ,  RAMOT, Roee ,  IYER, Shwetha ,  D'ALESSIO, Joseph Anthony ,  WUERSCH, Kuno ,  PISTORIUS, Dominik ,  MANCHADO ROBLES, Eusebio ,  BUNTIN, Kathrin ,  GABRIEL, Doris ,  FESSLER, Boris ,  MAUDENS, Pierre ,  ROMANET, Vincent ,  BLUEMMEL, Anne-Sophie ,  HOFFMASTER, Keith ,  KHERA, Eshita ,  YERRAMILLI-RAO, Padmaja

IPC分类号： A01N43/00

CPC分类号： C12N15/52 ,  C12N9/93 ,  C12N9/1029 ,  C12R2001/0120210501 ,  C12N9/0006 ,  C12N9/0071 ,  C07K14/705 ,  C12P21/02 ,  C07K14/4722 ,  C07K16/28 ,  A61K47/6849 ,  A61K47/6865 ,  A61K47/6811 ,  A61K47/6803

摘要： This application discloses microorganisms and methods of producing GNAQ/GNA11 inhibitors and methods of making antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The disclosure also relates to formulations comprising antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor and methods of treating or preventing cancer using the formulations.

公开(公告)号：EP4323526A1

公开(公告)日：2024-02-21

申请号：EP22726208.6

申请日：2022-04-15

申请人： Novartis AG

发明人： FAN, Liqiong ,  HAINZL, Dominik ,  RAMOT, Roee ,  IYER, Shwetha ,  D'ALESSIO, Joseph Anthony ,  WUERSCH, Kuno ,  PISTORIUS, Dominik ,  MANCHADO ROBLES, Eusebio ,  BUNTIN, Kathrin ,  GABRIEL, Doris ,  FESSLER, Boris ,  MAUDENS, Pierre ,  ROMANET, Vincent ,  BLUEMMEL, Anne-Sophie ,  HOFFMASTER, Keith ,  KHERA, Eshita ,  YERRAMILLI-RAO, Padmaja

IPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  A01N43/00